Oxytocin in the periaqueductal gray participates in pain modulation in the rat by influencing endogenous opiate peptides

Yang, Jun; Liang, Jinying; Pan, Yan-Juan; Qiu, Ping; Zhang, Jing; Fang, Hao; Wang, Daxin

doi:10.1016/j.peptides.2011.03.007

Cited by 59 publications

(46 citation statements)

References 33 publications

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“…This excludes the cardiovascular complications, which goes in line with the previous study of Yang et al (2011b). However ABP and HR were significantly decreased after intravenous OXT administration and this coincided with the previous study of Yang et al( 2014) which demonstrated that intravenous OXT promoted a direct negative inotropic and chronotropic effects in rats (Yaksh et al, 2014).…”

Section: Discussionsupporting

confidence: 91%

“…(1) Control group: Rats received intrathecal saline; (2) The OXT group (A: Rats injected with single 3.12 ng OXT/10 µl saline intrathecally (Yang et al, 2011b); B: Rats received the same dose of OXT once intravenously), and (3) The antagonist group (C: rats injected by single dose of 0.32 µM l-glutamate sodium /1 µl saline intrathecally (Yang et al, 2006) followed by intrathecal OXT).…”

Section: Experimental Designmentioning

confidence: 99%

“…However, great interest is taken nowadays concerned about the role of OXT in pain modulation, especially because it is a natural hormone and released normally under various conditions (Yang et al, 2011b) however, its analgesic action is debated. In this study, we clarified the analgesic role of oxytocin; hope to understand the mechanism of OXT in *Corresponding author.…”

Section: Introductionmentioning

confidence: 99%

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Oxytocin ameliorates the deleterious effect of pain in adult male rats

el‐Rady¹,

Ahmed²,

El-Aziz³

et al. 2017

J. Physiol. Pathophysiol.

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Oxytocin (OXT) is a neuropeptide with a peripheral role in reproduction, though it may have a central effect. The aim of the study is to verify its cental pathophysiological mechanisms on experimental rats. Rats were divided into control, OXT (which divided into intrathecal OXT and IV OXT subgroups), and antagonist group: OXT and l-glutamate Na + subgroup with measuring of pain threshold, cardiovascular changes, and pain related mediators (OXT, serotonin, and dopamine) and histopathological examination. A significant increase of the pain threshold in rats was observed in intrathecal oxytocin subgroup. The response was absent in IV oxytocin subgroup The analgesic effect of OXT contributes to direct increase of OXT receptors maker in different brain areas and spinal cord and through glutamergic pathway. Besides, OXT induces significant increase in the levels of neurotransmitters related to the pain in serum and brain homogenate of this experimental study. Administration of OXT can counterbalance the pain troubles without major detectable detrimental effects on cardiovascular system.

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Section: Discussionsupporting

confidence: 91%

Section: Experimental Designmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Oxytocin ameliorates the deleterious effect of pain in adult male rats

el‐Rady¹,

Ahmed²,

El-Aziz³

et al. 2017

J. Physiol. Pathophysiol.

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show abstract

“…Nonetheless, our results indicate that OT-ir fibres are quite dense in several centres of the midbrain and hindbrain. For instance, a relatively dense OT-ir innervation in the PAG may be involved in OT regulation of opiate-mediated nociception (Yang et al 2011). Considerable OT-ir innervation is also seen in the substantia nigra and ventral tegmental area.…”

Section: Distribution Of Ot-immunoreactive Processesmentioning

confidence: 99%

Distribution of oxytocin and co-localization with arginine vasopressin in the brain of mice

et al. 2015

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Oxytocin (OT) and vasopressin (AVP) play a major role in social behaviours. Mice have become the species of choice for neurobiology of social behaviour due to identification of mouse pheromones and the advantage of genetically modified mice. However, neuroanatomical data on nonapeptidergic systems in mice are fragmentary, especially concerning the central distribution of OT. Therefore, we analyse the immunoreactivity for OT and its neurophysin in the brain of male and female mice (strain CD1). Further, we combine immunofluorescent detection of OT and AVP to locate cells co-expressing both peptides and their putative axonal processes. The results indicate that OT is present in cells of the neurosecretory paraventricular (Pa) and supraoptic hypothalamic nuclei (SON). From the anterior SON, OTergic cells extend into the medial amygdala, where a sparse cell population occupies its ventral anterior and posterior divisions. Co-expression of OT and AVP in these nuclei is rare. Moreover, a remarkable OTergic cell group is found near the ventral bed nucleus of the stria terminalis (BST), distributed between the anterodorsal preoptic nucleus and the nucleus of anterior commissure (ADP/AC). This cell group, the rostral edge of the Pa and the periventricular hypothalamus display frequent OT + AVP double labelling, with a general dominance of OT over AVP immunoreactivity. Fibres with similar immunoreactivity profile innervate the accumbens shell and core, central amygdala and portions of the intervening BST. These data, together with data in the literature on rats, suggest that the projections of ADP/AC nonapeptidergic cells onto these brain centres could promote pup-motivated behaviours and inhibit pup avoidance during motherhood.

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“…Furthermore, microinjection of oxytocin in the RMg (Wang et al, 2003) and PAG (Yang et al, 2011) decreases the pain threshold in rats. Admittedly, we have no direct evidence that OTR activation in our experiments is the responsible for the c-Fos increase.…”

mentioning

confidence: 94%