Oxytocin in the periaqueductal grey regulates nociception in the rat

Yang, Jun; Li, Peng; Liang, Jinying; Pan, Yan-Juan; Yan, Xi-Qin; Yan, Fei; Fang, Hao; Zhang, Xiaoyi; Zhang, Jing; Qiu, Ping; Wang, Daxin

doi:10.1016/j.regpep.2011.04.007

Cited by 41 publications

(35 citation statements)

References 23 publications

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“…In the central nervous system, OT is involved in the antinociceptive process through OTR in the periaqueductal gray (Yang et al, 2011a), caudate nucleus and spinal cord (Yu et al, 2003). In the peripheral nervous system, OT inhibition on ATP-activated currents is mediated by OTR in membranes of DRG neurons (Yang et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Oxytocin-induced membrane hyperpolarization in pain-sensitive dorsal root ganglia neurons mediated by Ca2+/nNOS/NO/KATP pathway

Gong

Gao

et al. 2015

Neuroscience

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Section: Discussionmentioning

confidence: 99%

Oxytocin-induced membrane hyperpolarization in pain-sensitive dorsal root ganglia neurons mediated by Ca2+/nNOS/NO/KATP pathway

Gong

Gao

et al. 2015

Neuroscience

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“…In addition to mGluR5, M1/M3 mAChR and OX1 receptors, the activation of other G q PCRs expressed in the PAG, such as oxytocin (Yang et al, 2011), neuropeptide S (Peng et al, 2010), bombesin 1 (Pert et al, 1980), and prostanoid EP1 (Oliva et al, 2006;Palazzo et al, 2011) receptors, also induced analgesia. It remains to be further elucidated if these G q PCRs can activate the G q PCR-PLC-DAGL-2-AG retrograde disinhibition mechanism and lead to analgesia.…”

Section: Orexin 1 Receptor Activationmentioning

confidence: 99%

No more pain upon G_q‐protein‐coupled receptor activation: role of endocannabinoids

Chiou

2014

Eur J of Neuroscience

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Marijuana has been used to relieve pain for centuries. The analgesic mechanism of its constituents, the cannabinoids, was only revealed after the discovery of cannabinoid receptors (CB1 and CB2) two decades ago. The subsequent identification of the endocannabinoids, anandamide and 2-arachidonoylglycerol (2-AG), and their biosynthetic and degradation enzymes discloses the therapeutic potential of compounds targeting the endocannabinoid system for pain control. Inhibitors of the anandamide and 2-AG degradation enzymes, fatty acid amide hydrolase and monoacylglycerol lipase, respectively, may be superior to direct cannabinoid receptor ligands as endocannabinoids are synthesized on demand and rapidly degraded, focusing action at generating sites. Recently, a promising strategy for pain relief was revealed in the periaqueductal gray (PAG). It is initiated by Gq-protein-coupled receptor (Gq PCR) activation of the phospholipase C-diacylglycerol lipase enzymatic cascade, generating 2-AG that produces inhibition of GABAergic transmission (disinhibition) in the PAG, thereby leading to analgesia. Here, we introduce the antinociceptive properties of exogenous cannabinoids and endocannabinoids, involving their biosynthesis and degradation processes, particularly in the PAG. We also review recent studies disclosing the Gq PCR-phospholipase C-diacylglycerol lipase-2-AG retrograde disinhibition mechanism in the PAG, induced by activating several Gq PCRs, including metabotropic glutamatergic (type 5 metabotropic glutamate receptor), muscarinic acetylcholine (M1/M3), and orexin 1 receptors. Disinhibition mediated by type 5 metabotropic glutamate receptor can be initiated by glutamate transporter inhibitors or indirectly by substance P, neurotensin, cholecystokinin and capsaicin. Finally, the putative role of 2-AG generated after activating the above neurotransmitter receptors in stress-induced analgesia is discussed.

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“…The key brain structures relaying nociception are the periaqueductal gray [128], central nucleus of amygdala [129], and the nucleus raphe magnus [130]. These structures are under tonic regulation of OXT.…”

Section: Nociception Analgesia and Addictionmentioning

confidence: 99%

Nonsocial Functions of Hypothalamic Oxytocin

et al. 2013

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Oxytocin (OXT) is a hypothalamic neuropeptide composed of nine amino acids. The functions of OXT cover a variety of social and nonsocial activity/behaviors. Therapeutic effects of OXT on aberrant social behaviors are attracting more attention, such as social memory, attachment, sexual behavior, maternal behavior, aggression, pair bonding, and trust. The nonsocial behaviors/functions of brain OXT have also received renewed attention, which covers brain development, reproduction, sex, endocrine, immune regulation, learning and memory, pain perception, energy balance, and almost all the functions of peripheral organ systems. Coordinating with brain OXT, locally produced OXT also involves the central and peripheral actions of OXT. Disorders in OXT secretion and functions can cause a series of aberrant social behaviors, such as depression, autism, and schizophrenia as well as disturbance of nonsocial behaviors/functions, such as anorexia, obesity, lactation failure, osteoporosis, diabetes, and carcinogenesis. As more and more OXT functions are identified, it is essential to provide a general view of OXT functions in order to explore the therapeutic potentials of OXT. In this review, we will focus on roles of hypothalamic OXT on central and peripheral nonsocial functions.

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Oxytocin in the periaqueductal grey regulates nociception in the rat

Cited by 41 publications

References 23 publications

Oxytocin-induced membrane hyperpolarization in pain-sensitive dorsal root ganglia neurons mediated by Ca2+/nNOS/NO/KATP pathway

Oxytocin-induced membrane hyperpolarization in pain-sensitive dorsal root ganglia neurons mediated by Ca2+/nNOS/NO/KATP pathway

No more pain upon G_q‐protein‐coupled receptor activation: role of endocannabinoids

Nonsocial Functions of Hypothalamic Oxytocin

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Oxytocin in the periaqueductal grey regulates nociception in the rat

Cited by 41 publications

References 23 publications

Oxytocin-induced membrane hyperpolarization in pain-sensitive dorsal root ganglia neurons mediated by Ca2+/nNOS/NO/KATP pathway

Oxytocin-induced membrane hyperpolarization in pain-sensitive dorsal root ganglia neurons mediated by Ca2+/nNOS/NO/KATP pathway

No more pain upon Gq‐protein‐coupled receptor activation: role of endocannabinoids

Nonsocial Functions of Hypothalamic Oxytocin

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No more pain upon G_q‐protein‐coupled receptor activation: role of endocannabinoids