Oxytocin inhibited stress induced visceral hypersensitivity, enteric glial cells activation, and release of proinflammatory cytokines in maternal separated rats

Xu, Shaoxian; Qin, Bin; Shi, Ameng; Zhao, Jing; Guo, Xiaoyan; Dong, Lei

doi:10.1016/j.ejphar.2017.11.018

Cited by 45 publications

(27 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Stress is an important contributor of VH. In a current study using a stress‐induced rat model, the authors suggested that VH is regulated via EGCs by the Toll‐like‐receptor (TLR4)/MyD88/NFkB (myeloid differentiation primary response 88, nuclear factor kappa‐light‐chain‐enhancer of activated B cells) signaling pathway (Xu et al, ).…”

Section: Introductionmentioning

confidence: 98%

Enteric Glia: S100, GFAP, and Beyond

Grundmann

Loris

Maas-Omlor

et al. 2019

The Anatomical Record

View full text Add to dashboard Cite

Since several years, the enteric nervous system (ENS) is getting more and more in the focus of gastrointestinal research. While the main interest was credited for years to the enteric neurons and their functional properties, less attention has been paid on the enteric glial cells (EGCs). Although the similarity of EGCs to central nervous system (CNS) astrocytes has been demonstrated a long time ago, EGCs were investigated in more detail only recently. Similar to the CNS, there is not "the" EGC, but also a broad range of diversity. Based on morphology and protein expression, such as glial fibrillary acidic protein (GFAP), S100, or Proteolipid-protein-1 (PLP1), several distinct glial types can be differentiated. Their heterogeneity in morphology, localization, and transcription as well as interaction with surrounding cells indicate versatile functional properties of these cells for gut function in health and disease. Although NG2 is found in a subset of CNS glial cells, it did not colocalize with the glial marker S100 or GFAP in the ENS. Instead, it in part colocalize with PDGFRα, as it does in the CNS, which do stain fibroblast-like cells in the gastrointestinal tract. Moreover, there seem to be species dependent differences. While GFAP is always found in the rodent ENS, this is completely different for the human gut.Only the compromised human ENS shows a significant amount of GFAPpositive glial cells. So, in general we can conclude that the EGC population is species specific and as complex as CNS glia. Anat Rec, 302:1333Rec, 302: -1344Rec, 302: , 2019.

show abstract

Section: Introductionmentioning

confidence: 98%

Enteric Glia: S100, GFAP, and Beyond

Grundmann

Loris

Maas-Omlor

et al. 2019

The Anatomical Record

View full text Add to dashboard Cite

show abstract

“…Beyond behavioral outcomes, early life stress is associated with a chronic inflammatory state (18) and glia cells abnormalities (19), which points out to altered neuroimmune signaling as a candidate pathway for mediating the consequences of postnatal stress on brain and cognitive functioning. For example, persistent higher levels of inflammatory markers in the brain, including TLR-4 and NF-κB, were detected in adult animals exposed to infant maternal deprivation (MD), which is a well-known experimental model of early life stress (20). In addition, NF-κB gene expression was upregulated in the mPFC of adolescent mice exposed to early life adversity, and this effect was associated with higher levels of cocaine-contextual memory (21).…”

Section: Introductionmentioning

confidence: 99%

Acute neuroinflammation elicited by TLR-3 systemic activation combined with early life stress induces working memory impairments in male adolescent mice

Viola

Creutzberg

Zaparte

et al. 2019

Behavioural Brain Research

View full text Add to dashboard Cite

“…Intraperitoneal injection of oxytocin to neonatal rats exposed to the water avoidance stress prevented the expected abnormal visceromotor response to colorectal distension. 22 Rats who received oxytocin had both lower proinflammatory cytokines and activation of enteric glial cells, which has been associated with stressinduced colonic hypercontraction. These investigations provide empirical credence to the novel concept of a preventative approach to FGIDs in children.…”

mentioning

confidence: 99%