Oxytocin‐loaded sustained‐release hydrogel graft provides accelerated bone formation: An experimental rat study

Akay, Ayşe Sümeyye; Arısan, Volkan; Cevher, Erdal; Sessevmez, Melike; Çam, Betül

doi:10.1002/jor.24607

Cited by 12 publications

(6 citation statements)

References 34 publications

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“…The systemic administration of OT promotes peri-implant bone healing and osseointegration of titanium implant in ovariectomized rats, increasing bone volume and improving trabecular micro-structure surrounding the implant [24]. Furthermore, Aykay AS et al showed, in a rat model, that a thermosensitive hydrogel graft incorporating OT-loaded PGLA microspheres provides an accelerated bone regeneration in the rat calvaria [25].…”

Section: Ot and Bone Microarchitecturementioning

confidence: 99%

Oxytocin and Bone: Review and Perspectives

Breuil

Trojani

Amri

2021

IJMS

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Recent data demonstrate the anabolic effect of oxytocin on bone. Bone cells express oxytocin receptors. Oxytocin promotes osteoblasts differentiation and function, leading to an increased bone formation with no effect on bone resorption and an improvement of bone microarchitecture. Oxytocin is synthetized by osteoblasts, and this synthesis is stimulated by estrogen. Animal studies demonstrate a direct action of oxytocin on bone, as the systemic administration of oxytocin prevents and reverses the bone loss induced by estrogen deficiency. Although oxytocin is involved in bone formation in both sexes during development, oxytocin treatment has no effect on male osteoporosis, underlining the importance of estrogen that amplifies its local autocrine and paracrine secretion. There are few human data showing a decrease in the oxytocin serum level in anorexia nervosa independently of estrogen and in amenorrheic women associated with impaired bone microarchitecture; in post-menopausal women a higher oxytocin serum level is associated with higher bone density, but not in osteoporotic men. Oxytocin displays many effects that may be beneficial in the management of osteoporosis, cardiovascular diseases, cognitive disorders, breast cancer, diabetes and body fat gain, all age-related diseases affecting elderly women, opening exciting therapeutic perspectives, although the issue is to find a single route, dosage and schedule able to reach all these targets.

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Section: Ot and Bone Microarchitecturementioning

confidence: 99%

Oxytocin and Bone: Review and Perspectives

Breuil

Trojani

Amri

2021

IJMS

View full text Add to dashboard Cite

show abstract

“…Among the polymeric carriers for oxytocin, solvent displacement method was utilized to synthesize poloxamer hydrogel scaffold, to encapsulate oxytocin in hydrogel graft constituted of poly(d, l-lactide-co-glycolide) (PLGA), β-tricalcium phosphate, and hydroxyapatite (CP). This method yielded 89.5% encapsulation efficiency, slowly release encapsulated oxytocin, and finally yielded significant regeneration of bone loss in rat calvaria [35].…”

Section: Nano Micro and Macro Materials For Delivery Of Agonists And Antagonistsmentioning

confidence: 93%

Molecular Aspects and Structure Activity Relationship of Oxytocin Agonists and Antagonist’s Role in Health

Chittepu¹,

Kalhotra²,

Gallardo-Velázquez³

et al. 2021

Oxytocin and Health

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Oxytocin (OT) and Oxytocin receptor signaling mechanism had emerged as a pathway for treatment of metabolic disorders like obesity, and diabetes. Both agonists and antagonists activity of the oxytocin receptor has beneficial aspects. This chapter will outline the receptor agonists and antagonist’s activity as a function of the features: hydrophobic regions, activity shapes, and positive and negative electrostatics. Also, their phenotype characteristics in various diseases like diabetes, obesity, cardiovascular and immune related diseases will be outlined. Finally, therapeutic development strategies for using various nanomaterials, and other biomaterials, as well as those in present use will be discussed.

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“…Thanks to their unique features, poly (D, Llactide coglycolide) PLGA copolymers have been used as local drug carrier for different types of biomolecules [ 96 ]. Sustained release micro spherical oxytocin hormone in a polymeric hydrogel scaffold mixed with biphasic calcium phosphates combination promotes bone repair in the rat calvarias [ 97 ]. Furthermore, OT-loaded b-TCP increases osteogenesis in rats with calvarias bone defects via an osteoinductive mechanism of action [ 77 ].…”

Section: Examples Of Repositioned Hormones For Bone and Periodontal T...mentioning

confidence: 99%

Locally Applied Repositioned Hormones for Oral Bone and Periodontal Tissue Engineering: A Narrative Review

et al. 2022

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Bone and periodontium are tissues that have a unique capacity to repair from harm. However, replacing or regrowing missing tissues is not always effective, and it becomes more difficult as the defect grows larger. Because of aging and the increased prevalence of debilitating disorders such as diabetes, there is a considerable increase in demand for orthopedic and periodontal surgical operations, and successful techniques for tissue regeneration are still required. Even with significant limitations, such as quantity and the need for a donor area, autogenous bone grafts remain the best solution. Topical administration methods integrate osteoconductive biomaterial and osteoinductive chemicals as hormones as alternative options. This is a promising method for removing the need for autogenous bone transplantation. Furthermore, despite enormous investigation, there is currently no single approach that can reproduce all the physiologic activities of autogenous bone transplants. The localized bioengineering technique uses biomaterials to administer different hormones to capitalize on the host’s regeneration capacity and capability, as well as resemble intrinsic therapy. The current study adds to the comprehension of the principle of hormone redirection and its local administration in both bone and periodontal tissue engineering.

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Oxytocin‐loaded sustained‐release hydrogel graft provides accelerated bone formation: An experimental rat study

Cited by 12 publications

References 34 publications

Oxytocin and Bone: Review and Perspectives

Oxytocin and Bone: Review and Perspectives

Molecular Aspects and Structure Activity Relationship of Oxytocin Agonists and Antagonist’s Role in Health

Locally Applied Repositioned Hormones for Oral Bone and Periodontal Tissue Engineering: A Narrative Review

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