Oxytocin protects against 3-NP induced learning and memory impairment in rats: Sex differences in behavioral and molecular responses to the context of prenatal stress

Moslemi, Mehdi; Khodagholi, Fariba; Asadi, Sareh; Rafiei, Shahrbanoo; Motamedi, Fereshteh

doi:10.1016/j.bbr.2019.112354

Cited by 13 publications

(11 citation statements)

References 73 publications

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Section: Methodsmentioning

confidence: 99%

“…for 7 days. 66,67 • Group 3 (EPO-treated group): rats received 3-NP (20 mg/kg/ day, i.p.) for 7 days and were then treated with EPO (5000 IU/ kg/day, i.p.)…”

Section: Methodsmentioning

confidence: 99%

“…The behavioral, biochemical, and histopathological changes associated with the subchronic administration of 3-NP (20 mg/kg/ day for 7 days) in rats were determined; this dose and duration regimen was previously reported by Tuńez et al 66 and Moslemi et al 67 We chose the EPO treatment dose according to a dose−response study conducted by Dzietko et al, 68 who tested recombinant EPO (rEPO) doses at 5000−30,000 IU/kg and showed that rEPO at 5000 IU/kg had significant neuroprotective effects in rodents. The 5000 IU/kg/day dose was replicated by Cevik et al 21 in an intracerebroventricular-streptozotocin animal model of AD.…”

Section: Methodsmentioning

confidence: 99%

“…throughout the study period. Group 2 (3-NP group): rats received 3-NP (20 mg/kg/day, i.p.) for 7 days. , Group 3 (EPO-treated group): rats received 3-NP (20 mg/kg/day, i.p.) for 7 days and were then treated with EPO (5000 IU/kg/day, i.p.…”

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Erythropoietin and Bacillus Calmette–Guérin Vaccination Mitigate 3-Nitropropionic Acid-Induced Huntington-like Disease in Rats by Modulating the PI3K/Akt/mTOR/P70S6K Pathway and Enhancing the Autophagy

Senousy

Hanafy

Shehata

et al. 2022

ACS Chem. Neurosci.

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Oxidative stress and mitochondrial dysfunction are among the mechanisms expected to explain the pathogenesis of Huntington's disease. Erythropoietin (EPO) and the Bacillus Calmette−Gueŕin (BCG) vaccine have neuroprotective effects against neurodegenerative diseases; however, the full mechanisms of their action are currently unclear. Here, for the first time, we investigated the neuroprotective effect of BCG vaccination in Huntington-like disease induced by 3-nitropropionic acid (3-NP) and its combination with EPO. Male Wistar rats were randomized into five groups: saline-treated control; 3-NP group (20 mg/kg/day, i.p.) for 7 days; EPO-treated group (5000 IU/kg/day, i.p.) for 14 days after 3-NP administration; live BCG vaccine prophylactic group (5000 cfu/g, i.p.) 10 days prior to 3-NP administration; and live BCG vaccine (5000 cfu/g, i.p.) 10 days before 3-NP administration, followed by EPO treatment (5000 IU/kg/day, i.p.) for 14 days. In a histopathological examination, striatum neurodegeneration was evidenced in the 3-NP injected rats. Administration of 3-NP elevated the levels of p-PI3K, p-Akt, p-mTOR, p-P70S6K, BAX, malondialdehyde, nitric oxide, and cytochrome oxidase while reduced the levels of BCL-2, superoxide dismutase, reduced glutathione, and the autophagy marker microtubule-associated protein light chain 3 in the striatum. EPO and BCG ameliorated the biochemical, histopathological, and behavioral derangements induced by 3-NP, with prominent neuroprotection observed in rats administered the BCG prophylactic combined with EPO treatment. These results highlight the role played by EPO and BCG in the management of 3-NP-induced Huntington-like disease by inhibiting the PI3K/Akt/mTOR/P70S6K pathway and enhancing the autophagy.

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Section: Methodsmentioning

confidence: 99%

“…for 7 days. 66,67 • Group 3 (EPO-treated group): rats received 3-NP (20 mg/kg/ day, i.p.) for 7 days and were then treated with EPO (5000 IU/ kg/day, i.p.)…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Erythropoietin and Bacillus Calmette–Guérin Vaccination Mitigate 3-Nitropropionic Acid-Induced Huntington-like Disease in Rats by Modulating the PI3K/Akt/mTOR/P70S6K Pathway and Enhancing the Autophagy

Senousy

Hanafy

Shehata

et al. 2022

ACS Chem. Neurosci.

View full text Add to dashboard Cite

show abstract

“…3-Nitropropionic acid (3-NP) is a mitochondrial toxin, used to generate a Huntington's disease (HD)-like model (112). In an experiment on 3-NP injected rats, OXT improved memory and learning performance in both male and female rats (113). However, intracerebroventricular (ICV) administration of OXT reversed defeat-induced social avoidance only in male rats (114).…”

Section: Central Nervous Systemmentioning

confidence: 99%

Oxytocin and Related Peptide Hormones: Candidate Anti-Inflammatory Therapy in Early Stages of Sepsis

et al. 2022

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Sepsis is a potentially life-threatening systemic inflammatory syndrome characterized by dysregulated host immunological responses to infection. Uncontrolled immune cell activation and exponential elevation in circulating cytokines can lead to sepsis, septic shock, multiple organ dysfunction syndrome, and death. Sepsis is associated with high re-hospitalization and recovery may be incomplete, with long term sequelae including post-sepsis syndrome. Consequently, sepsis continues to be a leading cause of morbidity and mortality across the world. In our recent review of human chorionic gonadotropin (hCG), we noted that its major properties including promotion of fertility, parturition, and lactation were described over a century ago. By contrast, the anti-inflammatory properties of this hormone have been recognized only more recently. Vasopressin, a hormone best known for its anti-diuretic effect, also has anti-inflammatory actions. Surprisingly, vasopressin’s close cousin, oxytocin, has broader and more potent anti-inflammatory effects than vasopressin and a larger number of pre-clinical studies supporting its potential role in limiting sepsis-associated organ damage. This review explores possible links between oxytocin and related octapeptide hormones and sepsis-related modulation of pro-inflammatory and anti-inflammatory activities.

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Effect of sex differences and time of oxytocin administration on treatment of rat model of autism spectrum disorder: Focused on necroptosis markers

Shariatpanahi,

Sojoudi,

Khodagholi

et al. 2023

Intl J of Devlp Neuroscience

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Autism is a neurodevelopmental disorder. A variety of molecular and cellular abnormalities leads to behavioral deficits in autism. Nevertheless, its etiology and treatment strategy are not completely understood. Oxytocin has recently shown improvements in social functioning. This study aimed to evaluate the necroptosis pathway for the neuroprotective effects of oxytocin in the valproic acid‐induced autism spectrum disorder model. The autism spectrum disorder was induced by valproic acid on gestational day 12.5 (600 mg/kg, intraperitoneally). Offspring received intranasal oxytocin (1 μg/μL) on the 21st and 40th days after birth. The offspring behaviors were scrutinized by self‐grooming, marble‐burying, three‐chamber, and Morris water maze tests. Western blot was performed on the hippocampus and amygdala tissues to investigate the expression of RIP3 and MLKL markers. The valproic acid group demonstrated more anxiety, repetitive behaviors, and expression of RIP3 and MLKL markers, and less social interaction and spatial memory compared with the control group. Oxytocin considerably improved social interactions, preference for social novelty, and memory. The elevated expression of RIP3 and MLKL markers in valproic acid‐induced autistic rats were alleviated after treatment with oxytocin. We also highlighted the importance of age and gender in autism spectrum disorder interventions. Our findings suggested that oxytocin administration was as an effective treatment in two areas of repetitive/stereotyped behaviors, social interactions/cognitive function. Notably, early administration of oxytocin resulted in better therapeutic responses in autism‐like behaviors. The molecular tests introduce oxytocin as a potential candidate for reducing the expression of necroptosis mediators in the brain. This reinforced our hypothesis that the necroptosis pathway takes part in autism spectrum disorder.

show abstract

Oxytocin protects against 3-NP induced learning and memory impairment in rats: Sex differences in behavioral and molecular responses to the context of prenatal stress

Cited by 13 publications

References 73 publications

Erythropoietin and Bacillus Calmette–Guérin Vaccination Mitigate 3-Nitropropionic Acid-Induced Huntington-like Disease in Rats by Modulating the PI3K/Akt/mTOR/P70S6K Pathway and Enhancing the Autophagy

Erythropoietin and Bacillus Calmette–Guérin Vaccination Mitigate 3-Nitropropionic Acid-Induced Huntington-like Disease in Rats by Modulating the PI3K/Akt/mTOR/P70S6K Pathway and Enhancing the Autophagy

Oxytocin and Related Peptide Hormones: Candidate Anti-Inflammatory Therapy in Early Stages of Sepsis

Effect of sex differences and time of oxytocin administration on treatment of rat model of autism spectrum disorder: Focused on necroptosis markers

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