Oxytocin, PTSD, and sexual abuse are associated with attention network intrinsic functional connectivity

Crum, Kathleen I.; Flanagan, Julianne C.; Vaughan, Brandon; Aloi, Joseph; Maria, Megan Moran-Santa; Back, Sudie E.; Brady, Kathleen T.; Joseph, Jane E.

doi:10.1016/j.pscychresns.2021.111345

Cited by 8 publications

(5 citation statements)

References 49 publications

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“…Based on the amygdalo‐centric model of PTSD (Rauch et al., 2006 ), this increased connectivity may reflect increased top–down prefrontal control over the fear response. Interestingly, oxytocin administration was also associated with reduced connectivity strength between dorsal (mostly cognitive) and ventral (mostly affective) attentional networks (Crum et al., 2021 ), suggesting that this pharmacological agent may help reduce focus on affective inner thoughts.…”

Section: Discussionmentioning

confidence: 99%

“…However, PTSD females showed reduced connectivity between the right basolateral to bilateral dorsal anterior cingulate cortex following oxytocin administration, compared to placebo (Koch et al, 2016), whereas placebo was associated with enhanced connectivity between these regions in PTSD females, compared to TEC females. Compared to TEC (n = 16), childhood trauma survivors with PTSD (n = 15) showed reduced the strength of resting state connectivity between the dorsal (DAN; made of the precuneus, occipital cortex, parietal cortices, middle and superior frontal gyri, temporo-occipital gyrus, and precentral gyrus) and ventral attentional networks (made of the supplemental motor area/superior frontal gyrus, bilateral superior and middle temporal gyrus, and bilateral inferior frontal gyrus) (Crum et al, 2021). This pattern of connectivity was found increased after oxytocin administration in both groups.…”

Section: 11mentioning

confidence: 99%

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Functional brain changes after alternative pharmacological interventions in posttraumatic stress disorder: A systematic review of clinical trials

Lotfinia,

Afshar,

Yaseri

et al. 2023

Brain and Behavior

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BackgroundPosttraumatic stress disorder (PTSD) is a complex and heterogeneous mental health condition that can develop after exposure to a traumatic event. Clinical trials have used alternative pharmacological agents to treat PTSD, but their associated neural correlates remain unclear. The present systematic review aims to summarize the changes in brain function associated with the use of these alternative pharmacological agents in PTSD.MethodsClinical trials using functional magnetic resonance imaging, either at rest or during the performance of tasks, were included if they compared the effects of alternative pharmacological agents between PTSD patients and either trauma‐exposed controls or never‐exposed healthy controls.ResultsSixteen studies were included, of which 11 used intranasal oxytocin, 2 used hydrocortisone, and 3 used delta‐9‐tetrahydrocannabinol (THC). Oxytocin administration was associated with the normalization of functional connectivity between the ventromedial prefrontal cortex and amygdala as well as enhanced the function of brain regions specifically involved in emotion processing (e.g., amygdala), working memory (e.g., dorsolateral prefrontal cortex), and reward (e.g., putamen). Hydrocortisone did not influence brain function at rest or during the performance of an autobiographical memory task, whereas THC was associated with the reduction of the amygdala and increased medial prefrontal cortex activation.ConclusionsThis systematic review identified preliminary evidence for normalizing brain function after the use of alternative pharmacological agents. Importantly, sex‐specific differences were noted, in particular when using oxytocin, that will require further investigation.

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Section: Discussionmentioning

confidence: 99%

Section: 11mentioning

confidence: 99%

Functional brain changes after alternative pharmacological interventions in posttraumatic stress disorder: A systematic review of clinical trials

Lotfinia,

Afshar,

Yaseri

et al. 2023

Brain and Behavior

View full text Add to dashboard Cite

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“…The relationship between DAN and childhood trauma has rarely been reported. A study on that oxytocin may help ameliorate attentional neurocircuitry dysfunction in individuals with PTSD and those with maltreatment histories, they found that PTSD and sexual abuse were associated with reduced ventral and dorsal neural attention networks (37). Severe childhood trauma can lead to attention-de cit hyperactivity disorder.…”

Section: Discussionmentioning

confidence: 99%

Differential alterations in topology property of resting state networks associated with mental health and childhood trauma

Feng

et al. 2022

Preprint

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Background Childhood trauma experiences leads to greater psychopathological vulnerability. We identified potential brain networks that are susceptible to childhood trauma, and to investigate these changes mediate childhood adversity and mental health. Methods In total 80 youth aged 18–30 years participants, subjects with and without childhood trauma underwent resting-state functional magnetic resonance imaging scanning. Independent component analysis (ICA) and graph theory based on resting-state functional networks were compared between the two groups. We established a correlation analysis between changes in topological properties and neglect/abuse, and explored the mediating effect on childhood trauma and mental health. In addition, sex as a moderator of relationships between neglect and change in the global efficiency within-network connectivity was confirmed. Results Our findings suggest that childhood trauma is associated with altered global efficiency of salience network (SAN) and default mode network (DMN). Compared with male, neglect was more likely to change global efficiency of the SAN in female. There were significant roles of changes in global efficiency of SAN/DMN as mediators between neglect and novelty-seeking of three-dimensional personality (TPQ-NS). Conclusions These findings highlight childhood trauma experiences altered resting-state functional networks in healthy youth. Such abnormality of brain circuitry is relevant to DMN and SAN especially.

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“…Finally, oxytocin was found to reduce the strength of resting state connectivity between the dorsal (DAN; made of the precuneus, occipital cortex, parietal cortices, middle and superior frontal gyri, temporooccipital gyrus, and precentral gyrus) and ventral attentional networks (VAN; made of the supplemental motor area/superior frontal gyrus, bilateral superior and middle temporal gyrus, and bilateral inferior frontal gyrus) in both a group of cases with childhood trauma related PTSD and TEC 48 . In this study there was no specific effects of oxytocin in the PTSD group.…”

Section: Oxytocinmentioning

confidence: 96%

“…Based on the amygdalo-centric model of PTSD 12 , this increased connectivity may reflect increased top-down prefrontal control over the fear response. Interestingly, oxytocin administration was also associated with reduced connectivity strength between dorsal (mostly cognitive) and ventral (mostly affective) attentional networks 48 , suggesting that this pharmacological agent may help reduce focus on affective inner thoughts.…”

Section: Functional Brain Changes After Oxytocin Administrationmentioning

confidence: 99%

Functional brain changes after pharmacological interventions in post-traumatic stress disorder: A systematic review of clinical trials

Lotfinia

Afshar

Yaseri

et al. 2023

Preprint

View full text Add to dashboard Cite

BackgroundPosttraumatic stress disorder (PTSD) is a complex and heterogeneous mental health condition that can develop after exposure to a traumatic event. Clinical trials have used new pharmacological agents to treat PTSD, but their associated neural correlates remain unclear. The present systematic review aims to summarise the changes in brain function associated with the use these pharmacological agents in PTSD.MethodsClinical trials using functional magnetic resonance imaging (fMRI), either at rest or during the performance of tasks, were included if they compared the effects of pharmacological agents in patients with PTSD to either trauma-exposed controls or never exposed to trauma healthy controls.ResultsTwelve studies were included, of which eight used intranasal oxytocin, two used hydrocortisone, and one used Tolcapone. Oxytocin administration was associated with normalisation of functional connectivity between the ventromedial prefrontal cortex and amygdala, as well as enhanced the function of brain regions specifically involved in emotion processing (e.g., amygdala), working memory (e.g., dorsolateral prefrontal cortex), reward (putamen). Hydrocortisone did not influence brain function at rest or during the performance of an autobiographical memory task, while tolcapone was associated with increased function in frontal, parietal and striatal regions during the performance of an emotional working memory task.ConclusionsThis systematic review identified preliminary evidence for normalizing brain function after use of alternative pharmacological agents to first-line pharmacological treatments.

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Oxytocin, PTSD, and sexual abuse are associated with attention network intrinsic functional connectivity

Cited by 8 publications

References 49 publications

Functional brain changes after alternative pharmacological interventions in posttraumatic stress disorder: A systematic review of clinical trials

Functional brain changes after alternative pharmacological interventions in posttraumatic stress disorder: A systematic review of clinical trials

Differential alterations in topology property of resting state networks associated with mental health and childhood trauma

Functional brain changes after pharmacological interventions in post-traumatic stress disorder: A systematic review of clinical trials

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