Oxytocin receptor gene rs53576 polymorphism modulates oxytocin–dopamine interaction and neuroticism traits—A SPECT study

Chang, Wei Hung; Lee, I. Hui; Chen, Kao Chin; Hung, Mei; Chiu, Nan Tsing; Yao, Wei Jen; Lu, Ru Band; Yang, Yen Kuang; Chen, Po See

doi:10.1016/j.psyneuen.2014.05.020

Cited by 50 publications

(36 citation statements)

References 53 publications

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“…As mentioned earlier, the amygdala is typically under-activated during such tasks in schizophrenia, thus it may be that higher A allelic load for this SNP is a contributing factor to this abnormal activation, especially given that the A allele of this SNP has been linked to risk for schizophrenia and general psychopathology (see above and Table 3). Relevant to the neurofunctional model of schizophrenia proposed by Rosenfeld et al (2011), evidence also suggests rs53576 influences striatal dopamine availability (Chang et al, 2014). Moreover, higher availability correlated with increased neuroticism in this sample of healthy individuals, further supporting the significant impact of OXTR allelic load on behaviour of a psychopathological nature (Chang et al, 2014).…”

Section: Panss Cgi-s Cgi-i Side Effectssupporting

confidence: 60%

“…Relevant to the neurofunctional model of schizophrenia proposed by Rosenfeld et al (2011), evidence also suggests rs53576 influences striatal dopamine availability (Chang et al, 2014). Moreover, higher availability correlated with increased neuroticism in this sample of healthy individuals, further supporting the significant impact of OXTR allelic load on behaviour of a psychopathological nature (Chang et al, 2014).…”

Section: Panss Cgi-s Cgi-i Side Effectssupporting

confidence: 60%

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Effects of oxytocin and genetic variants on brain and behaviour: Implications for treatment in schizophrenia

Bartholomeusz

Ganella

Labuschagne

et al. 2015

Schizophrenia Research

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Section: Panss Cgi-s Cgi-i Side Effectssupporting

confidence: 60%

Section: Panss Cgi-s Cgi-i Side Effectssupporting

confidence: 60%

Effects of oxytocin and genetic variants on brain and behaviour: Implications for treatment in schizophrenia

Bartholomeusz

Ganella

Labuschagne

et al. 2015

Schizophrenia Research

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“…Because its neuroprotective action is dependent on estrogen receptor activity (45), we conjecture that estrogen receptor genes may moderate the correlation between impatience and LTL. Last, we genotype the oxytocin receptor (OXTR) SNP rs53576 that is linked to a considerable range of cognitive and social cognitive processes (46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59). Prior evidence shows that individuals possessing the rs53576 G allele, relative to those with the A allele, are less affected by psychological stress, indicated by lower cortisol response (51) and greater psychological resources (52).…”

mentioning

confidence: 99%

Delay discounting, genetic sensitivity, and leukocyte telomere length

Yim

Zhang

Shalev

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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In a graying world, there is an increasing interest in correlates of aging, especially those found in early life. Leukocyte telomere length (LTL) is an emerging marker of aging at the cellular level, but little is known regarding its link with poor decision making that often entails being overly impatient. Here we investigate the relationship between LTL and the degree of impatience, which is measured in the laboratory using an incentivized delay discounting task. In a sample of 1,158 Han Chinese undergraduates, we observe that steeper delay discounting, indexing higher degree of impatience, is negatively associated with LTL. The relationship is robust after controlling for health-related variables, as well as risk attitude-another important determinant of decision making. LTL in females is more sensitive to impatience than in males. We then asked if genes possibly modulate the effect of impatient behavior on LTL. The oxytocin receptor gene (OXTR) polymorphism rs53576, which has figured prominently in investigations of social cognition and psychological resources, and the estrogen receptor β gene (ESR2) polymorphism rs2978381, one of two gonadal sex hormone genes, significantly mitigate the negative effect of impatience on cellular aging in females. The current results contribute to understanding the relationship between preferences in decision making, particularly impatience, and cellular aging, for the first time to our knowledge. Notably, oxytocin and estrogen receptor polymorphisms temper accelerated cellular aging in young females who tend to make impatient choices.telomere length | delay discounting | risk attitude | oxytocin receptor | estrogen receptor

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“…It has been established that oxytocin may influence emotion, cognition, personality and social behaviors [1,2,3,4]. Animal studies have demonstrated that oxytocin may inhibit the development of opioid tolerance and diminish self-medication with opioids via several mechanisms, such as attenuating the withdrawal reaction [5,6].…”

Section: Introductionmentioning

confidence: 99%

“…Oxytocin was also proposed to play a role in diminishing the withdrawal effect induced by methylenedioxy-N-methylamphetamine (MDMA) and sedatives, such as γ-hydroxybutyrate, via its positive effects on the social behavior and mood of humans [8]. Meanwhile, it is worthy of note that oxytocin interacts with the dopaminergic system [4,9]. Oxytocin neurons express dopamine receptors in the hypothalamus [10], while the dopamine and oxytocin pathways converge in the frontal cortex, ventral striatum and ventral tegmental areas [11,12].…”

Section: Introductionmentioning

confidence: 99%

Association between Blood Level of Plasma Oxytocin and Novelty Seeking among Methadone-Maintained Heroin Users

Lin¹,

Lee²,

Tsai³

et al. 2015

Neuropsychobiology

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Background: Oxytocin interacts with the dopaminergic system, which plays a role in addiction behaviors. The association between oxytocin and addiction was confirmed in animal studies. Novelty seeking is one of the predictors and indicators of drug addiction. The aim of the present study was to probe the association between oxytocin and novelty seeking. Methods: The study was conducted in a methadone maintenance therapy clinic of a medical center in Taiwan; 77 patients with heroin dependency were enrolled. Plasma oxytocin was measured using an ELISA kit. Novelty seeking was measured using an established instrument (the novelty seeking subscale of the Tridimensional Personality Questionnaire). Results: A significant negative association (ρ = -0.27, p = 0.02; r = -0.34, p = 0.003) between the blood level of plasma oxytocin and novelty seeking was found. This association was significant after controlling the effects of perceived social support and the dosage of methadone (r = -0.32, p = 0.006). Conclusion: The negative association between oxytocin and novelty seeking may provide insight into future treatments for addiction.

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Oxytocin receptor gene rs53576 polymorphism modulates oxytocin–dopamine interaction and neuroticism traits—A SPECT study

Cited by 50 publications

References 53 publications

Effects of oxytocin and genetic variants on brain and behaviour: Implications for treatment in schizophrenia

Effects of oxytocin and genetic variants on brain and behaviour: Implications for treatment in schizophrenia

Delay discounting, genetic sensitivity, and leukocyte telomere length

Association between Blood Level of Plasma Oxytocin and Novelty Seeking among Methadone-Maintained Heroin Users

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