Oxytocin receptor signaling in the hippocampus: Role in regulating neuronal excitability, network oscillatory activity, synaptic plasticity and social memory

Lin, Yu Ting; Hsu, Kuei Sen

doi:10.1016/j.pneurobio.2018.10.003

Cited by 72 publications

(70 citation statements)

References 191 publications

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“…A total of 50 rats was used in this study. Two weeks after the trauma (SPS), control (n = 14) and SPS (n = 36) rats were tested for anxiety (EPM) and arousal (ASR) to define vulnerable and resilient rats, according to previously validated criteria 16,35 . Vulnerable rats were those exhibiting EMP and ASR scores above ½ standard deviation of the CTRL group mean.…”

Section: Vulnerability To Traumamentioning

confidence: 99%

“…In the central nervous system, it is released by two neuronal populations of the paraventricular nucleus, the magnocellular neurons which project to the posterior pituitary, and the parvocellular neurons which project on the anterior pituitary, directly into the circulation [12][13][14] . The oxytocin effects are transduced via the oxytocin receptors abundantly expressed in regions involved in emotions and cognition like the hippocampus, the septum, and the amygdala 15,16 .…”

Section: Introductionmentioning

confidence: 99%

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Emotional remodeling with oxytocin durably rescues trauma-induced behavioral and neuro-morphological changes in rats: a promising treatment for PTSD

et al. 2020

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Recent evidence indicates that reactivated memories are malleable and can integrate new information upon their reactivation. We injected rats with oxytocin to investigate whether the delivery of a drug which dampens anxiety and fear before the reactivation of trauma memory decreases the emotional load of the original representation and durably alleviates PTSD-like symptoms. Rats exposed to the single prolonged stress (SPS) model of PTSD were classified 15 and 17 days later as either resilient or vulnerable to trauma on the basis of their anxiety and arousal scores. Following 2 other weeks, they received an intracerebral infusion of oxytocin (0.1 µg/1 µL) or saline 40 min before their trauma memory was reactivated by exposure to SPS reminders. PTSD-like symptoms and reactivity to PTSD-related cues were examined 3-14 days after oxytocin treatment. Results showed that vulnerable rats treated with saline exhibited a robust PTSD syndrome including increased anxiety and decreased arousal, as well as intense fear reactions to SPS sensory and contextual cues. Exposure to a combination of those cues resulted in c-fos hypo-activation and dendritic arbor retraction in prefrontal cortex and amygdala neurons, relative to resilient rats. Remarkably, 83% of vulnerable rats subjected to oxytocin-based emotional remodeling exhibited a resilient phenotype, and SPS-induced morphological alterations in prelimbic cortex and basolateral amygdala were eliminated. Our findings emphasize the translational potential of the present oxytocin-based emotional remodeling protocol which, when administered even long after the trauma, produces deep reprocessing of traumatic memories and durable attenuation of the PTSD symptomatology.

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Section: Vulnerability To Traumamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Emotional remodeling with oxytocin durably rescues trauma-induced behavioral and neuro-morphological changes in rats: a promising treatment for PTSD

et al. 2020

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“…Oxytocin exerts physiological functions by binding to oxytocin receptor (OXTR) [16]. OXTRs distribute mainly in hippocampus, hypothalamus, nucleus accumbens and also in uterine smooth muscle cells, vascular endothelial cells, adipocytes [17]. The number of OXTRs in different brain regions is closely related to the social behavior [18,19].…”

Section: Introductionmentioning

confidence: 99%

LncRNA Gm14205 induces astrocytic NLRP3 inflammasome activation via inhibiting oxytocin receptor in postpartum depression

Zhu

Tang

2020

Bioscience Reports

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Postpartum depression (PPD) is a kind of mental disorder characterized by persistent low emotions in puerperium. The most significant physiological change in postpartum is lactation which is regulated by oxytocin receptor (OXTR). However, whether OXTR is related to pathological process of PPD and the potential mechanism still remain unclear. In the present study, we prepared hormone-simulated pregnancy (HSP)-induced PPD mouse model and found that the protein level of OXTR in hippocampus of PPD model mice was downregulated and NLRP3 inflammasome was activated. We identified five lncRNAs related to PPD by transcriptome sequencing, including 3 up-regulated ones and 2 down-regulated ones. The five lncRNAs are associated with the signaling pathway of OXTR according to the bioinformatics analysis. Furthermore, we focused on one of the five lncRNAs, Gm14205, and found that it targeted OXTR which inhibited astrocytic NLRP3 inflammasome activation in hippocampal primary astrocytes. These findings illustrate that OXTR has protective effects in PPD by inhibiting NLRP3 inflammasome activation and provides a new strategy for targeting lncRNA Gm14205 in the pathogenesis of PPD.

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“…It also serves as a relay between the hippocampus and other cortical sensory-processing brain regions 56,57 . To the extent that OXTR binding in the presubiculum and hippocampus play similar roles in regulating plasticity and social cognition 18,20 , our finding suggests that increased OXTR binding in the hippocampal formation is a potential mechanism underlying the changes in neural plasticity that accompany parenthood. However, in the absence of cognition or plasticity data in this study, further investigation is needed to explore this hypothesis.…”

Section: Discussionmentioning

confidence: 83%

“…Oxytocin is a key hormonal regulator of many of the brain regions involved in parenting and broader social attachment 3 , 15 , 17 , including the hippocampus 18 . In the brain, oxytocin is produced in the paraventricular and supraoptic nuclei of the hypothalamus in response to different types of social and tactile stimuli and exerts its neuro-modulatory effects in various brain regions by binding to the oxytocin receptor (OXTR), a G-protein-coupled receptor 19 .…”

Section: Introductionmentioning

confidence: 99%

Oxytocin receptor binding in the titi monkey hippocampal formation is associated with parental status and partner affiliation

Baxter

Anderson

Seelke

et al. 2020

Sci Rep

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Social cognition is facilitated by oxytocin receptors (OXTR) in the hippocampus, a brain region that changes dynamically with pregnancy, parturition, and parenting experience. We investigated the impact of parenthood on hippocampal OXTR in male and female titi monkeys, a pair-bonding primate species that exhibits biparental care of offspring. We hypothesized that in postmortem brain tissue, OXTR binding in the hippocampal formation would differ between parents and non-parents, and that OXTR density would correlate with frequencies of observed parenting and affiliative behaviors between partners. Subjects were 10 adult titi monkeys. OXTR binding in the hippocampus (CA1, CA2/3, CA4, dentate gyrus, subiculum) and presubiculum layers (PSB1, PSB3) was determined using receptor autoradiography. The average frequency of partner affiliation (Proximity, Contact, and Tail Twining) and infant carrying were determined from longitudinal observations (5–6 per day). Analyses showed that parents exhibited higher OXTR binding than non-parents in PSB1 (t(8) = − 2.33, p = 0.048), and that OXTR binding in the total presubiculm correlated negatively with Proximity (r = − 0.88) and Contact (r = − 0.91), but not Tail Twining or infant carrying. These results suggest that OXTR binding in the presubiculum supports pair bonding and parenting behavior, potentially by mediating changes in hippocampal plasticity.

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Oxytocin receptor signaling in the hippocampus: Role in regulating neuronal excitability, network oscillatory activity, synaptic plasticity and social memory

Cited by 72 publications

References 191 publications

Emotional remodeling with oxytocin durably rescues trauma-induced behavioral and neuro-morphological changes in rats: a promising treatment for PTSD

Emotional remodeling with oxytocin durably rescues trauma-induced behavioral and neuro-morphological changes in rats: a promising treatment for PTSD

LncRNA Gm14205 induces astrocytic NLRP3 inflammasome activation via inhibiting oxytocin receptor in postpartum depression

Oxytocin receptor binding in the titi monkey hippocampal formation is associated with parental status and partner affiliation

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