“…This might provoke an accumulation of unfolded proteins (UPs) and/or additional stress‐related factors, which in turn can be transported to the neighboring neurons through microvesicles, enhancing the cellular stress response by HFD in target neurons (Galluzzi et al, 2018; Pascua‐Maestro et al, 2018). (2) Oxytocin, an anorexigenic peptide, might be induced in response of HFD, and its deletion in the hypothalamus increases food consumption and body weight (Blevins et al, 2016; Castro et al, 2013; Inada et al, 2022; Yoon et al, 2019); therefore, in the Gfap‐Cre , Bmal1 loxP/loxP ‐HFD mice, this pathway might be contributing enhancing the ER‐stress response (Klein et al, 2016). (3) The enhancement of the anti‐stress response in the VMH, might induce the sympathetic BAT activation (Enerback, 2010; Liñares‐Pose et al, 2018; Orozco‐Solis et al, 2016).…”