Oxytocin via oxytocin receptor excites neurons in the endopiriform nucleus of juvenile mice

Biggs, Lindsey M.; Hammock, Elizabeth A. D.

doi:10.1038/s41598-022-15390-5

Cited by 7 publications

(5 citation statements)

References 73 publications

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“…The mouse CLA predicts upcoming movement in between intertrial intervals ( Chevée et al, 2022 ). Interestingly, Oxt neurons project to the CLA-Endopiriform complex in the mouse brain, an area with high density of OxtRs, the functional relevance of which has yet to be explored ( Dubois-Dauphin et al, 1992 ; Newmaster et al, 2020 ; Biggs and Hammock, 2022 ).…”

Section: Oxytocin Associated Circuitry In Internal State Controlmentioning

confidence: 99%

Missing pieces in decoding the brain oxytocin puzzle: Functional insights from mouse brain wiring diagrams

Manjila

Betty²,

Kim³

2022

Front. Neurosci.

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The hypothalamic neuropeptide, oxytocin (Oxt), has been the focus of research for decades due to its effects on body physiology, neural circuits, and various behaviors. Oxt elicits a multitude of actions mainly through its receptor, the Oxt receptor (OxtR). Despite past research to understand the central projections of Oxt neurons and OxtR- coupled signaling pathways in different brain areas, it remains unclear how this nonapeptide exhibits such pleiotropic effects while integrating external and internal information. Most reviews in the field either focus on neuroanatomy of the Oxt-OxtR system, or on the functional effects of Oxt in specific brain areas. Here, we provide a review by integrating brain wide connectivity of Oxt neurons and their downstream circuits with OxtR expression in mice. We categorize Oxt connected brain regions into three functional modules that regulate the internal state, somatic visceral, and cognitive response. Each module contains three neural circuits that process distinct behavioral effects. Broad innervations on functional circuits (e.g., basal ganglia for motor behavior) enable Oxt signaling to exert coordinated modulation in functionally inter-connected circuits. Moreover, Oxt acts as a neuromodulator of neuromodulations to broadly control the overall state of the brain. Lastly, we discuss the mismatch between Oxt projections and OxtR expression across various regions of the mouse brain. In summary, this review brings forth functional circuit-based analysis of Oxt connectivity across the whole brain in light of Oxt release and OxtR expression and provides a perspective guide to future studies.

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Section: Oxytocin Associated Circuitry In Internal State Controlmentioning

confidence: 99%

Missing pieces in decoding the brain oxytocin puzzle: Functional insights from mouse brain wiring diagrams

Manjila

Betty²,

Kim³

2022

Front. Neurosci.

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“…The neurohormone oxytocin received a lot of attention for its involvement in social behaviors, especially in maternal behavior ( Pedersen et al, 1982 ; Marlin et al, 2015 ; Carcea et al, 2021 ), reproductive behavior ( Insel et al, 1997 ) but also for its role in affiliative behaviors between partners ( Williams et al, 1994 ; Insel and Hulihan, 1995 ), prosocial behavior and social cognition in humans. Currently, it is proposed that oxytocin’s role in social behaviors emerges from oxytocinergic modulation of the salience of social and emotional stimuli ( Insel and Young, 2001 ; Resendez et al, 2020 ; Alaerts et al, 2021 ; Smith et al, 2021 ; Biggs and Hammock, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Oxytocin predicts positive affect gains in a role-play interaction

Berceanu,

Papasteri,

Sofonea

et al. 2024

Front. Psychol.

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IntroductionRole-play, a key creative process in theatre, is used in therapeutic interventions to improve social skills, emotion regulation, and memory. Although role-play is widely used as a psychotherapeutic technique, its mechanisms of action are not fully understood.MethodsOur study introduces a standardized controlled procedure for promoting role-play in the laboratory based on the portrayal of a fictional persona and examines its effects on anxiety, affect, prosocial attitudes, and salivary oxytocin dynamics in 38 participants.ResultsIn our experiment, role-play significantly increased positive affect and prosocial attitudes and decreased anxiety compared to a control condition. Basal salivary oxytocin levels predicted higher gains in positive affect following role-play, suggesting a specific moderating effect of oxytocin. The fictional persona used in the procedure was rated as very happy by subjects, creating a positive social context for the role-play social interaction.DiscussionsWe propose that the observed moderation effect of oxytocin in our study is specific to the role-play condition due to the capacity of role-play to generate an affective regulatory context based on congruency toward the emotional state of the fictional persona. Our findings indicate that basal oxytocin levels could predict specific outcomes of role-play in therapeutical setting. We discuss several psychological and biological mechanisms that could account for the observed effects of role-play and how oxytocin could act as a substrate for them.

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“…Conversely, IHC markers like calbindin‐D28 (CB), calretinin (CR), somatostatin (SST), myelin basic protein (MBP), and tyrosine hydroxylase show a paucity of labeling in the CL area that can also help define its borders (Barbier et al., 2017 ; Borroto‐Escuela & Fuxe, 2020 ; Celio, 1990 ; Davila et al., 2005 ; Druga et al., 2014 ; Graf et al., 2020 ; Marriott et al., 2021 ; Real et al., 2003 ; Wang et al., 2017 , 2023 ). The chemo‐architecture of the DEn is not as well characterized but shows an elevated expression of oxytocin and dopamine receptors (Biggs & Hammock, 2022 ; Lothmann et al., 2021 ; Yoshida et al., 1988 ). A complete characterization of all these markers is beyond the scope of this article, and instead we have selected a few markers, whose combined expression in the same tissue would yield a robust fiber‐ and cytoarchitectural basis for delineating the CLCX.…”

Section: Introductionmentioning

confidence: 99%

A multifaceted architectural framework of the mouse claustrum complex

Grimstvedt,

Shelton,

Hoerder‐Suabedissen

et al. 2023

J of Comparative Neurology

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Accurate anatomical characterizations are necessary to investigate neural circuitry on a fine scale, but for the rodent claustrum complex (CLCX), this has yet to be fully accomplished. The CLCX is generally considered to comprise two major subdivisions, the claustrum (CL) and the dorsal endopiriform nucleus (DEn), but regional boundaries to these areas are debated. To address this, we conducted a multifaceted analysis of fiber‐ and cytoarchitecture, genetic marker expression, and connectivity using mice of both sexes, to create a comprehensive guide for identifying and delineating borders to CLCX, including an online reference atlas. Our data indicated four distinct subregions within CLCX, subdividing both CL and DEn into two. Additionally, we conducted brain‐wide tracing of inputs to CLCX using a transgenic mouse line. Immunohistochemical staining against myelin basic protein (MBP), parvalbumin (PV), and calbindin (CB) revealed intricate fiber‐architectural patterns enabling precise delineations of CLCX and its subregions. Myelinated fibers were abundant dorsally in CL but absent ventrally, whereas PV expressing fibers occupied the entire CL. CB staining revealed a central gap within CL, also visible anterior to the striatum. The Nr2f2, Npsr1, and Cplx3 genes expressed specifically within different subregions of the CLCX, and Rprm helped delineate the CL‐insular border. Furthermore, cells in CL projecting to the retrosplenial cortex were located within the myelin sparse area. By combining own experimental data with digitally available datasets of gene expression and input connectivity, we could demonstrate that the proposed delineation scheme allows anchoring of datasets from different origins to a common reference framework.

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Oxytocin via oxytocin receptor excites neurons in the endopiriform nucleus of juvenile mice

Cited by 7 publications

References 73 publications

Missing pieces in decoding the brain oxytocin puzzle: Functional insights from mouse brain wiring diagrams

Missing pieces in decoding the brain oxytocin puzzle: Functional insights from mouse brain wiring diagrams

Oxytocin predicts positive affect gains in a role-play interaction

A multifaceted architectural framework of the mouse claustrum complex

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