Oxytocinergic regulation of cardiovascular function: studies  in oxytocin-deficient mice

Michelini, Lisete Compagno; Marcelo, Marialuisa C.; Amico, Janet A.; Morris, Mariana

doi:10.1152/ajpheart.00774.2002

Cited by 57 publications

(43 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There is also evidence from rats that oxytocin can downregulate CRF gene expression in the PVN (Nomura et al, 2003). In addition, mice that are genetically deficient for either oxytocin (Michelini et al, 2003;Mantella et al, 2004) or the oxytocin receptor (Takayanagi et al, 2005) tend to be highly reactive to stressors.…”

Section: Discussionmentioning

confidence: 99%

Social isolation induces behavioral and neuroendocrine disturbances relevant to depression in female and male prairie voles

Grippo

Gerena

Huang

et al. 2007

Psychoneuroendocrinology

302

279

View full text Add to dashboard Cite

SummarySupportive social interactions may be protective against stressors and certain mental and physical illness, while social isolation may be a powerful stressor. Prairie voles are socially monogamous rodents that model some of the behavioral and physiological traits displayed by humans, including sensitivity to social isolation. Neuroendocrine and behavioral parameters, selected for their relevance to stress and depression, were measured in adult female and male prairie voles following 4 weeks of social isolation versus paired housing. In Experiment 1, oxytocin-immunoreactive cell density was higher in the hypothalamic paraventricular nucleus (PVN) and plasma oxytocin was elevated in isolated females, but not males. In Experiment 2, sucrose intake, used as an operational definition of hedonia, was reduced in both sexes following 4 weeks of isolation. Animals then received a residentintruder test, and were sacrificed either 10 minutes later for the analysis of circulating hormones and peptides, or two hours later to examine neural activation, indexed by c-Fos expression in PVN cells immunoreactive for oxytocin or corticotropin-releasing factor (CRF). Compared to paired animals, plasma oxytocin, ACTH and corticosterone were elevated in isolated females and plasma oxytocin was elevated in isolated males, following the resident-intruder test. The proportion of cells doublelabeled for c-Fos and oxytocin or c-Fos and CRF was elevated in isolated females, and the proportion of cells double-labeled for c-Fos and oxytocin was elevated in isolated males following this test. These findings suggest that social isolation induces behavioral and neuroendocrine responses relevant to depression in male and female prairie voles, although neuroendocrine responses in females may be especially sensitive to isolation.

show abstract

Section: Discussionmentioning

confidence: 99%

Social isolation induces behavioral and neuroendocrine disturbances relevant to depression in female and male prairie voles

Grippo

Gerena

Huang

et al. 2007

Psychoneuroendocrinology

302

279

View full text Add to dashboard Cite

show abstract

“…Recent studies in oxytocin knockout mice have confirmed that these animals have abnormal autonomic and baroreflex control over heart rate (HR) and BP, and that female mice lacking oxytocin have increased anxiety-like behaviors (Mantella, Vollmer, Li, & Amico, 2003;Michelini, Marcelo, Amico, & Morris, 2003). Other recent research in both male and female animal models indicates that in addition to its production within the hypothalamus, oxytocin is produced and released in the heart and the vasculature, and that oxytocin specifically activates receptors that are present in both sites, leading to decreases in HR, contractile force and vascular resistance (Jankowski et al, 2000;Mukaddam-Daher, Yin, Roy, Gutkowska, & Cardinal, 2001;Thibonnier et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Deficits in plasma oxytocin responses and increased negative affect, stress, and blood pressure in mothers with cocaine exposure during pregnancy

Light

Grewen

Amico

et al. 2004

Addictive Behaviors

101

View full text Add to dashboard Cite

In animals, oxytocin enhances maternal behavior and lowers blood pressure (BP) and negative affect, while parturitional cocaine disrupts oxytocin activity and increases maternal neglect and aggression. Thus, we compared oxytocin, BP, maternal behavior, and affect in mothers of infants who used cocaine (cocaine, n = 10) or did not (no drug, n = 25) during pregnancy. Laboratory BP and circulating oxytocin, catecholamines, and cortisol were examined before and during a speech stressor on 2 days, with vs. without prestress baby holding. Ambulatory monitoring assessed BP, urinary norepinephrine, and cortisol for 24 h at home. The cocaine group had lower oxytocin levels, greater hostility and depressed mood, less support from others and mastery over life events, higher BP during all events of testing without the baby, and higher ambulatory BP and urinary norepinephrine at home, while cortisol and epinephrine responses were blunted. Although they tended to hold their babies less often at home, baby holding in the laboratory led to decreased BP in cocaine mothers who then did not differ from no-drug mothers in BP or observed affect.

show abstract

“…Although OT is well recognized for its role in reproduction, recent discoveries suggest that OT is also involved in regulation of fluid balance, blood pressure (BP), and cardiac function. [1][2][3][4] Oxytocinergic neurons innervate brain regions important in cardiovascular control, such as the nucleus tractus solitarius, locus ceruleus, dorsal motor nucleus of the vagus, and intermediolateral cell column in the spinal cord. [5][6][7] OT and OT receptors are present in the vasculature, heart, and kidney, 2 and OT has effects on BP, renal function, and salt intake.…”

mentioning

confidence: 99%

“…21 These animals also showed imbalances in autonomic control, an enhanced sympathetic reserve, and alterations in baroreflex function. 4 The present studies were designed to expand these findings in the OTKO model: (1) to determine the effect of volume depletion on salt and water intake; (2) to determine the effect of central Ang II stimulation on salt and water intakes; and (3) to determine baseline BP and the response to central Ang II. Volume depletion was produced by PEG treatment, which activates neural and endocrine reflexes, resulting in enhanced intake of salt and water to compensate for fluid losses.…”

mentioning

confidence: 99%

Salt Appetite and the Renin-Angiotensin System

et al. 2003

Self Cite

View full text Add to dashboard Cite

Abstract-To explore the role of oxytocin in the regulation of salt appetite and blood pressure, we conducted studies in oxytocin gene-knockout mice and determined (1) blood pressure and heart rate during day and night periods, (2) salt appetite after iso-osmotic volume depletion, and (3) salt appetite and blood pressure after central injection of angiotensin II. Long-term arterial catheters were inserted, and blood pressure and heart rate were recorded for 24 hours. There was a modest decrease in blood pressure and heart rate in knockout mice. Salt appetite was measured with a 2-bottle choice (water and 2% NaCl), with measurement of licking activity. Mice were injected subcutaneously with 30% polyethylene glycol (0.5 mL), and voluntary intakes were measured for 24 hours. Knockout mice consumed 3 times the amount of NaCl than did controls, 276Ϯ77 vs 90Ϯ38 licks/24 h (PϽ0.05). Water consumption was similar between groups. Angiotensin II (5, 50, and 200 ng/3 L) injected intracerebroventricularly produced dose-related increases in intake, with no differences between the groups. The 50-ng dose of angiotensin II elicited salt and water intakes of 151Ϯ43 vs 160Ϯ33 licks and 250Ϯ53 vs and 200Ϯ51 licks, respectively (control vs knockout). The pressor response to angiotensin II was not different between the groups. Results suggest that oxytocin plays a role in the regulation of blood pressure and salt appetite, specifically as mediated by volume receptors, and that the renin-angiotensin system is not involved in these changes. Key Words: mice Ⅲ blood pressure Ⅲ angiotensin Ⅲ renin-angiotensin system Ⅲ water-electrolyte balance Ⅲ sodium O xytocin (OT) is a posterior pituitary hormone that has a wide range of effects on target tissues from the brain to the vasculature. Although OT is well recognized for its role in reproduction, recent discoveries suggest that OT is also involved in regulation of fluid balance, blood pressure (BP), and cardiac function. [1][2][3][4] Oxytocinergic neurons innervate brain regions important in cardiovascular control, such as the nucleus tractus solitarius, locus ceruleus, dorsal motor nucleus of the vagus, and intermediolateral cell column in the spinal cord. 5-7 OT and OT receptors are present in the vasculature, heart, and kidney, 2 and OT has effects on BP, renal function, and salt intake. 1,3 Hypovolemia is a stimulus for cardiovascular and neuroendocrine reflexes, resulting in sympathetic, adrenal, and hypothalamic activation. 8 Experimentally, volume depletion is often induced by the injection of large-molecular-weight colloids, such as polyethylene glycol (PEG), which acts to draw iso-osmotic fluid from the tissues. Time-course and pharmacologic antagonist studies suggest that PEG-induced OT release inhibits salt intake. 9,10 There is also evidence for an OT-specific response to increased osmolality, rather than sodium. 11 A role for central angiotensin II (Ang II) in mediating the OT responses was suggested, because OT antagonists potentiated the salt intake induced by Ang II. 12,13 I...

show abstract

Oxytocinergic regulation of cardiovascular function: studies in oxytocin-deficient mice

Cited by 57 publications

References 45 publications

Social isolation induces behavioral and neuroendocrine disturbances relevant to depression in female and male prairie voles

Social isolation induces behavioral and neuroendocrine disturbances relevant to depression in female and male prairie voles

Deficits in plasma oxytocin responses and increased negative affect, stress, and blood pressure in mothers with cocaine exposure during pregnancy

Salt Appetite and the Renin-Angiotensin System

Contact Info

Product

Resources

About