Oyster polysaccharides ameliorate intestinal mucositis and improve metabolism in 5-fluorouracil-treated S180 tumour-bearing mice

Cai, Bingna; Pan, Jianyu; Chen, Hua; Chen, Xin; Ye, Ziqing; Yuan, Huabiao; Sun, Han‐Dong; Wan, Peng

doi:10.1016/j.carbpol.2020.117545

Cited by 41 publications

(29 citation statements)

References 52 publications

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“…Rikenellaceae_RC9_gut_group was positively correlated abnormal glucose and lipid metabolism with a high-fat diet [ 28 ]. After reducing the abundance of Rikenellaceae_RC9_gut_group and Prevotellaceae_UCG-001 , the microorganisms that produced propionic acid and butyric acid increased due to the increase in available substrates [ 42 ]. We found that Rikenellaceae_RC9_gut_group was negatively correlated with in vitro fermentation parameters through correlation analysis, which showed that EOC changed the VFA composition by affected the abundance of Rikenellaceae_RC9_gut_group , and had a positive effect on maintaining the normal glucose and lipid metabolism of sheep.…”

Section: Discussionmentioning

confidence: 99%

Effect of Oregano Oil and Cobalt Lactate on Sheep In Vitro Digestibility, Fermentation Characteristics and Rumen Microbial Community

Wang

Zhang

et al. 2022

Animals

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The objective of this experiment was to evaluate the effect of different EOC (0.1425% cobalt lactate + 1.13% oregano essential oil + 98.7275% carrier) levels on in vitro rumen fermentation and microbial changes. Six EOC levels (treatments: 0 mg·L−1, CON; 50 mg·L−1, EOC1; 100 mg·L−1, EOC2; 400 mg·L−1, EOC3; 800 mg·L−1, EOC4 and 1500 mg·L−1, EOC5) were selected to be used to in vitro incubation. The in vitro dry matter digestibility (IVDMD), in vitro neutral detergent fiber digestibility (IVNDFD), in vitro acid detergent fiber digestibility (IVNDFD), pH, ammonia-nitrogen (NH3-N) concentration, total volatile fatty acid (TVFA) concentration and microbial protein (MCP) concentration were measured after 48 h incubation, after which the groups with significant nutrient digestibility and fermentation parameters were subjected to 16S rRNA sequencing. The results showed that the total gas production (GP) of the EOC5 group was higher than that of the other groups after 12 h of in vitro incubation. TVFA, NH3-N and MCP concentrations were also shown to be higher in group EOC5 than those in other groups (p < 0.05), while NH3-N and MCP concentrations in the EOC2 group were lower than those in other groups significantly (p < 0.05). The molar ratio of acetic acid decreased while the molar ratio of propionic acid increased after the addition of EOC. 16S rRNA sequencing revealed that the rumen microbiota was altered in response to adding EOC, especially for the EOC5 treatment, with firmicutes shown to be the most abundant (43.1%). The relative abundance of Rikenellaceae_RC9_gut_group was significantly lower, while the relative abundance of uncultured_bacterium_f_Muribaculaceae and Succiniclasticum was significantly higher in the EOC5 group than those in other groups (p < 0.05). Comprehensive analysis showed that EOC (1500 mg·L−1) could significantly increase gas production, alter sheep rumen fermentation parameters and microbiota composition.

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Section: Discussionmentioning

confidence: 99%

Effect of Oregano Oil and Cobalt Lactate on Sheep In Vitro Digestibility, Fermentation Characteristics and Rumen Microbial Community

Wang

Zhang

et al. 2022

Animals

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“…In addition, 5-FU does not specifically target tumor cells and thus also causes damage to normal cells, resulting in potentially severe adverse effects. Moreover, 5-FU treatment can also alter the gut microbiota ( Wardill et al, 2014 ; Hamouda et al, 2017 ), which influences intestinal barrier function and drives colon inflammation ( Cai et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Albuca Bracteate Polysaccharides Synergistically Enhance the Anti-Tumor Efficacy of 5-Fluorouracil Against Colorectal Cancer by Modulating β-Catenin Signaling and Intestinal Flora

Xue

Tan

et al. 2021

Front. Pharmacol.

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The first-line treatment for colorectal cancer (CRC) is 5-fluorouracil (5-FU). However, the efficacy of this treatment is sometimes limited owing to chemoresistance as well as treatment-associated intestinal mucositis and other adverse events. Growing evidence suggests that certain phytochemicals have therapeutic and cancer-preventing properties. Further, the synergistic interactions between many such plant-derived products and chemotherapeutic drugs have been linked to improved therapeutic efficacy. Polysaccharides extracted from Albuca bracteata (Thunb.) J.C.Manning and Goldblatt (ABP) have been reported to exhibit anti-oxidant, anti-inflammatory, and anti-tumor properties. In this study, murine CRC cells (CT26) and a murine model of CRC were used to examine the anti-tumor properties of ABP and explore the mechanism underlying the synergistic interactions between ABP and 5-FU. Our results revealed that ABP could inhibit tumor cell proliferation, invasion, and migratory activity in vitro and inhibited tumor progression in vivo by suppressing β-catenin signaling. Additionally, treatment with a combination of ABP and 5-FU resulted in better outcomes than treatment with either agent alone. Moreover, this combination therapy resulted in the specific enrichment of Ruminococcus, Anaerostipes, and Oscillospira in the intestinal microbiota and increased fecal short-chain fatty acid (SCFA) levels (acetic acid, propionic acid, and butyric acid). The improvement in the intestinal microbiota and the increase in beneficial SCFAs contributed to enhanced therapeutic outcomes and reduced the adverse effects of 5-FU. Together, these data suggest that ABP exhibits anti-neoplastic activity and can effectively enhance the efficacy of 5-FU in CRC treatment. Therefore, further research on the application of ABP in the development of novel anti-tumor drugs and adjuvant compounds is warranted and could improve the outcomes of CRC patients.

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“…Researchers have paid close attention to the effect of different chemotherapeutic agents on the expression of TLRs over the past years. Treatment with 5-FU was found to significantly enhance protein expression of TLR-2 and TLR-4 [27,29,54,55], but slightly reduce the expression of TLR-9 [29]. In addition, the effect on the expression of TLR-2 were different from that of TLR-4.…”

Section: Chemotherapeutic Drugs Affecting Expression Of Tlrsmentioning

confidence: 87%

“…In addition, in recent years, natural products including Chinese herbal medicines have displayed distinct clinical outcomes in managing chemotherapy-induced side effects including gut mucositis, nausea and vomiting [103][104][105], and some of them have been verified in animal experiments, such as Wuzi Yanzong Pills [106], Shengjiang Xiexin decoction [107], Gegen Qinlian decoction [108], Qingjie Fuzheng Granule [109], Amomi Fructus [110], Steamed rehmannia root [111], Patchouli [27,112], Saikosaponin-A [7], Aquilaria agallocha [113] and Andrographolide [114], with the underlying mechanisms of action involving antioxidation, anti-inflammation and anti-apoptosis. In addition, some ingredients extracted from Crassostrea hongkongensis [55], Dendrobium sonia [115], Dendrobium huoshanense [116], Schisandrae chinensis [117], Salvia miltiorrhiza [118], Scutellaria baicalensis [119], and Pogostemon cablin [27] are likely to regulate gut microbiota through promoting the proliferation of commensal microbiota and inhibiting pathogenic bacteria. Furthermore, Patchouli alcohol extract and Patchouli oil have been proved to alleviate CIM by modulating TLR signaling pathways [27,112].…”

Section: Prophylactic Effect Of Antibiotics Probiotics and Natural Productsmentioning

confidence: 99%

Chemotherapy-Induced Intestinal Microbiota Dysbiosis Impairs Mucosal Homeostasis by Modulating Toll-like Receptor Signaling Pathways

Wei

Wen

Chen

2021

IJMS

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Chemotherapy-induced intestinal mucositis, a painful debilitating condition affecting up to 40–100% of patients undergoing chemotherapy, can reduce the patients’ quality of life, add health care costs and even postpone cancer treatment. In recent years, the relationships between intestinal microbiota dysbiosis and mucositis have drawn much attention in mucositis research. Chemotherapy can shape intestinal microbiota, which, in turn, can aggravate the mucositis through toll-like receptor (TLR) signaling pathways, leading to an increased expression of inflammatory mediators and elevated epithelial cell apoptosis but decreased epithelial cell differentiation and mucosal regeneration. This review summarizes relevant studies related to the relationships of mucositis with chemotherapy regimens, microbiota, TLRs, inflammatory mediators, and intestinal homeostasis, aiming to explore how gut microbiota affects the pathogenesis of mucositis and provides potential new strategies for mucositis alleviation and treatment and development of new therapies.

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Oyster polysaccharides ameliorate intestinal mucositis and improve metabolism in 5-fluorouracil-treated S180 tumour-bearing mice

Cited by 41 publications

References 52 publications

Effect of Oregano Oil and Cobalt Lactate on Sheep In Vitro Digestibility, Fermentation Characteristics and Rumen Microbial Community

Effect of Oregano Oil and Cobalt Lactate on Sheep In Vitro Digestibility, Fermentation Characteristics and Rumen Microbial Community

Albuca Bracteate Polysaccharides Synergistically Enhance the Anti-Tumor Efficacy of 5-Fluorouracil Against Colorectal Cancer by Modulating β-Catenin Signaling and Intestinal Flora

Chemotherapy-Induced Intestinal Microbiota Dysbiosis Impairs Mucosal Homeostasis by Modulating Toll-like Receptor Signaling Pathways

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