h i g h l i g h t sStudied microwave (MW) pretreatment in a large pilot-scale sludge reduction system. The sludge quantity to be finally disposed off was reduced by 38.60% on average. Achieved 13.64% cost savings compared to operation without MW pretreatment. a r t i c l e i n f o /d, when coupled with a MW sludge pretreatment unit, the sludge production and sludge yield were greatly reduced by 38.60% and to 0.35 kg VSS/kg COD consumed , respectively. The total operating cost of the lysis-cryptic growth system was 13.64% lower than that of the CAS system without a MW unit.