Ozone- A Biological Therapy in Dentistry- Reality or Myth?????

Naik, Saraswathi V; Rajeshwari, K; Kohli, Shivani; Zohabhasan, Sayyad; Bhatia, Shekhar

doi:10.2174/1874210601610010196

Cited by 51 publications

(54 citation statements)

References 29 publications

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“…[ 25 ] Other authors showed less cytotoxic effect of ozone, as a potential antiseptic agent, if compared to other antimicrobials such as CHX, sodium hypochlorite, or hydrogen peroxide. [ 26 ] Therefore, ozone gel fulfills optimal cell biological characteristics in terms of biocompatibility for oral application. [ 15 ]…”

Section: Discussionmentioning

confidence: 99%

Cytotoxicity evaluation of a new ozonized olive oil

et al. 2018

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Objective:The cytocompatibility of a new ozonized olive oil toward immortalized human gingival fibroblasts (HGFs) was evaluated and compared with two common antimicrobial agents based on chlorhexidine digluconate (CHX).Materials and Methods:The cytocompatibility of the samples was tested on immortalized HGF-1 cells by 3-(4, 5-dimethyl thiazolyl-2)-2,5-diphenyltetrazolium bromide (MTT) assay. The cells were incubated for 2 or 24 h with increasing dilution of ozonized olive oil or CHX agents. The percentage of viable cells was calculated relative to control cells set to 100%.Results:The ozonized olive oil is cytocompatible, and the viability values of the cells treated for 2 or 24 h with increasing concentrations of ozonized olive oil were significantly higher (P < 0.01) compared with the values obtained using CHX.Conclusions:The present data demonstrate that due to its cytocompatibility, the new ozonized olive oil could be considered an alternative antibacterial agent.

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Section: Discussionmentioning

confidence: 99%

Cytotoxicity evaluation of a new ozonized olive oil

et al. 2018

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“…O 3 devices should be handled with care due to its strong oxidizing effect and potential toxicity 114 ; therefore, the manufacturer-recommended protocol for administration should be strictly followed.…”

Section: Disadvantages and Side Effectsmentioning

confidence: 99%

“…114 Ozone is known to be a strong oxidizer. Hence, it possesses antibacterial activities by disrupting the cell wall and cytoplasmic membrane of bacteria and therefore destruction of the microorganism.…”

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confidence: 99%

Effects and Effectiveness of Cavity Disinfectants in Operative Dentistry: A Literature Review

Bin-Shuwaish¹

2016

The Journal of Contemporary Dental Practice

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The degree of success in the elimination of bacteria during cavity preparation and prior to the insertion of a restoration may increase the longevity of the restoration and therefore the success of the restorative procedure. The complete eradication of bacteria in a caries-affected tooth, during cavity preparation, is considered a difficult clinical task. In addition to weakening the tooth structure, attempts to excavate extensive carious tissue completely, by only mechanical procedures, may affect the vitality of the pulp. Therefore, disinfection of the cavity preparation after caries excavation can aid in the elimination of bacterial remnants that can be responsible for recurrent caries, postoperative sensitivity, and failure of the restoration. However, the effects of disinfectants on the restorative treatment have been a major concern for dental clinicians and researchers. This review aims to explore existing literature and provide information about different materials and techniques that have been used for disinfecting cavity preparations and their effects and effectiveness in operative dentistry and, therefore, helps dental practitioners with clini cal decision to use cavity disinfectants during restorative procedures. Antimicrobial effectiveness and effects on the pulp and dental restorations, in addition to possible side effects, were all reviewed in this paper.

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“…According to microbiological research data, the ozone is capable of killing all the known types of gram-positive and gram-negative bacteria, including the Pseudomona aeruginosa and Eschericea coli, both of which are extremely resistant to antibiotics (7).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Topical Ozone Therapy on Socket Healing in Rabbits With Induced Diabetes Mellitus

Shehata

Elba

Kawana

2019

Alexandria Dental Journal

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INTRODUCTION:Ozone (O3) gas is a molecule consisting of three atoms of oxygen in a dynamically unstable structure due to the presence of mesomeric states. Ozone therapy has been utilized and heavily studied for more than a century. Its effects on bone are proven and consistent. It enhance osteoblastic activity and new bone formation. Diabetes mellitus (DM) is a chronic metabolic disease that potentially affect bone metabolism, structure, and mineral density. OBJECTIVES: to evaluate histologically the possible effect of ozone therapy on bone healing after tooth extraction in rabbits with alloxan induced diabetes mellitus. MATERIALS AND METHODS Thirty adult male New Zealand rabbits weighing 1500-2500 grams (approximately six months of age) will be divided into 3 equal groups: group I;(control group), group II; (diabetic group): diabetes was induced by a single intravenous injection of alloxan in a dose of 100 mg/kg and group III:(Ozone group) rabbits was treated as in diabetic group then they was treated with ozone therapy which will be applied topically in the form of gel inside the tooth socket. Rabbits were sacrificed after six weeks. Each sample were dissected and prepared for histological evaluation. RESULTS: in diabetic group the socket showed empty central region surrounded by disorganization bony trabeculae. The bony trabeculae surrounded less vascular spaces and more fibrous tissue.in diabetic group treated with ozone therapy the socket showed complete filling of the socket with newly formed bone.The socket with newly formed bone surrounding highly vascular bone marrow. CONCLUSIONS: Ozone gel application accelerates socket healing and enhances bone formation in diabetes mellitus

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Ozone- A Biological Therapy in Dentistry- Reality or Myth?????

Cited by 51 publications

References 29 publications

Cytotoxicity evaluation of a new ozonized olive oil

Cytotoxicity evaluation of a new ozonized olive oil

Effects and Effectiveness of Cavity Disinfectants in Operative Dentistry: A Literature Review

Evaluation of Topical Ozone Therapy on Socket Healing in Rabbits With Induced Diabetes Mellitus

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