Ozone adjunct treatment in facing multidrug‐resistant bacteria?

The Oxygen–Ozone Adjunct Medical Treatment According to the Protocols from the Italian Scientific Society of Oxygen–Ozone Therapy: How Ozone Applications in the Blood Can Influence Clinical Therapy Success via the Modulation of Cell Biology and Immunity

“…The strategy is based on the Janus hallmark held by ozone [39], inasmuch as ozone can directly kill bacteria invading a post-surgical or traumatic Ozone can be easily applied to infected and ulcerous wounds as an antimicrobial and anti-inflammatory topical formulation [22]. This ability is due, respectively, to the antimicrobial effect of the pro-oxidant potential of ozone and to the anti-inflammatory activity held by hormetic ozone at a systemic level, and this encouraged the Italian Scientific Society of Oxygen-Ozone Therapy (SIOOT) in challenging these properties to address the huge concern of antibiotic resistance [23,24].…”

“…The concurrent action of the topical ozone, working in a quite direct way, and of blood-derived ozonized products, such as 4-HNE, which acts as a modulatory agent, should warrant for the complete effectiveness of ozone in the clearance of MDR bacteria in humans. Moreover, the ability of ozone via autohemotherapy to elicit a "mito-hormetic" mechanism [14,21,23,24,99] may explain how ozone has the ability to restrain inflammation by inducing a macrophage-tolerant state in an LPS-induced immune exacerbation [71].…”