Ozone Exposure and Asthma Attack in Children

Huang, Wan-Ting; Wu, Jinzhun; Lin, Xinhua

doi:10.3389/fped.2022.830897

Cited by 13 publications

(8 citation statements)

References 35 publications

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“…Acute ozone exposure in men causes sputum neutropenia in 30% of subjects, especially young children, women and those with persistent cardiorespiratory disease [ 32 ]. Exposure to O 3 can promote airway infections and increase the risk of asthma attacks [ 33 , 34 ]. A similar finding was noted in our study.…”

Section: Discussionmentioning

confidence: 99%

Short-Term Exposure Effect of Ambient Fine Particulate Matter, Ozone and Cold Temperature on Emergency Room Visits for Asthma Patients

Cheng

Yen

Hsiao

et al. 2023

Toxics

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(1) Background: The acute effects of ozone, cold temperature and particulate matter less than 2.5 μm (PM2.5) in size related to asthma attacks are well known worldwide. The adverse effects of ozone and cold temperature on asthma morbidity in Taiwan are still inconclusive. (2) Methods: This retrospective study included patients who had asthma emergency room visits (ERVs) from 1 January 2016 to 31 December 2019 in a regional hospital in Taiwan. The short-term negative effects were estimated using Distributed Lag Non-Linear Models (DLNMs) for the relative risks (RRs) of asthma ERVs associated with PM2.5, ozone and cold temperature exposures within 5 days. (3) Results: There was a significant association between a 10 ppm increase in PM2.5 exposure and asthma ERVs at a 2-day lag (RR 1.166, 95% confidence interval (C.I.): 1.051–1.294). There was a significant association between ozone and asthma ERVs at a 1-day lag (RR 1.179, 95% C.I.: 1.034–1.345). The ambient temperature in cold weather compared with the temperature of minimum asthma ERV showed an RR of 1.214, 95% C.I.: 1.009–1.252 at a 1-day lag. (4) Conclusions: This study provides evidence that short-term exposure to fine suspended particulates, ozone and inverse temperature is associated with asthma exacerbation.

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Section: Discussionmentioning

confidence: 99%

Short-Term Exposure Effect of Ambient Fine Particulate Matter, Ozone and Cold Temperature on Emergency Room Visits for Asthma Patients

Cheng

Yen

Hsiao

et al. 2023

Toxics

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“…A case-crossover study in China also reported that exposure to higher than 80 µg/m 3 O 3 increased the risk of reduced lung function. 34 Thus, patients with EOA could be the population at risk upon exposure to air pollution. We found that PM had distinct effects on endpoints in patients with asthma and allergic sensitization.…”

Section: Dovepressmentioning

confidence: 99%

Different Impacts of Traffic-Related Air Pollution on Early-Onset and Late-Onset Asthma

Lin,

Makrufardi,

Tung

et al. 2024

JAA

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Background Early-onset asthma (EOA) and late-onset asthma (LOA) are two distinct phenotypes. Air pollution has been associated with an increase in poorer asthma outcomes. The objective of this study was to examine the effects of traffic-related air pollution (TRAP) on asthma outcomes in EOA and LOA patients. Methods A cross-sectional study was conducted on 675 asthma patients (LOA: 415) recruited from a major medical center in Taiwan. The land-use regression (LUR) model was used to estimate the level of exposure to PM 10 , PM 2.5 , NO 2 , and O 3 on an individual level. We investigated the association between TRAP and asthma outcomes in EOA and LOA patients, stratified by allergic sensitization status, using a regression approach. Results An increase in PM 10 was associated with younger age of onset, increased asthma duration, and decreased lung function in EOA patients ( p <0.05). An increase in PM 10 was associated with older age of onset, and decreased asthma duration, eosinophil count, and Asthma Control Test (ACT) score in LOA patients. An increase in PM 2.5 was associated with younger age of onset, increased asthma duration, decreased eosinophil count, and lung function in EOA patients ( p <0.05). An increase in PM 2.5 was associated with decreased lung function and ACT score in LOA patients. An increase in NO 2 was associated with increased eosinophil count and decreased lung function in EOA patients ( p <0.05). An increase in O 3 was associated with decreased lung function in LOA patients ( p <0.05). In addition, associations of TRAP with age of onset and eosinophil counts were mainly observed in both EOA and LOA patients with allergic sensitization, and an association with ACT was mainly observed in LOA patients without allergic sensitization. Conclusion The impact of TRAP on age of onset, eosinophil count, and lung function in EOA patients, and ACT in LOA patients, was affected by the status of allergic sensitization.

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“…PM 2.5 , NO 2 , SO 2 , and O 3 were significantly associated with increased risks of pediatric asthma ERVs in Shanghai, China [12]. An O 3 -8 h concentration above 80 µg/m 3 contributed to an increased risk of asthma attacks in children [13]. PM was related to motor vehicle emissions and industrial production was related to increasing pediatric asthma visits in USA [14].…”

Section: Introductionmentioning

confidence: 95%

The Influence of Fine Particulate Matter and Cold Weather on Emergency Room Interventions for Childhood Asthma

Hsiao,

Cheng,

Hong

et al. 2024

Life

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(1) Background: Children are the most vulnerable to pollution due to their decreased stature, heightened respiratory rate, and frequent outdoor engagement. PM2.5, nitrogen dioxide (NO2), ozone, and cold weather are associated with pediatric asthma. In this study, we investigated the nexus between air pollution, climate factors, and pediatric asthma emergency room visits (ERVs). (2) Method: Pediatric asthma ERV data for healthcare quality from the Taiwanese National Insurance in the Taipei area were obtained from 2015 to 2019. Air pollution and climate factor data were also collected. Poisson regression was employed to determine the relationships with relative risks (RRs). (3) Results: The incidence of pediatric asthma ERVs decreased, with a crude RR of 0.983 (95% CI: 0.98–0.986, p < 0.001). Fine particulate matter (PM2.5) had an adjusted RR of 1.102 (95% CI: 1.037–1.172, p = 0.002) and a 7.7 µg/m3 increase, and air temperature had an adjusted RR of 0.813 (95% CI: 0.745–0.887, p < 0.001) comparing between the highest and lowest quarter air temperature associated with pediatric asthma ERVs. (4) Conclusions: This inquiry underscores the positive associations of PM2.5 and cold weather with pediatric asthma ERVs. The findings could guide the government to establish policies to reduce air pollution and promote children’s health.

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Ozone Exposure and Asthma Attack in Children

Cited by 13 publications

References 35 publications

Short-Term Exposure Effect of Ambient Fine Particulate Matter, Ozone and Cold Temperature on Emergency Room Visits for Asthma Patients

Short-Term Exposure Effect of Ambient Fine Particulate Matter, Ozone and Cold Temperature on Emergency Room Visits for Asthma Patients

Different Impacts of Traffic-Related Air Pollution on Early-Onset and Late-Onset Asthma

The Influence of Fine Particulate Matter and Cold Weather on Emergency Room Interventions for Childhood Asthma

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