Ozone Increases Atrial Natriuretic Peptides in Heart, Lung and Circulation of Aged vs. Adult Animals

Vesely, David L.; Giordano, Amy T.; Raska-Emery, Patricia; Montgomery, Mark R.

doi:10.1159/000213590

Cited by 5 publications

(1 citation statement)

References 26 publications

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“…Exposure to ozone has also been shown to have consequences on the health of rats, including an immediate effect on heart function [12,13], resulting in pulmonary edema and lowering of blood pressure [14]. Alternately, if ozonization improves or maintains production levels, is safe for producers and birds, and reduces ammonia and bacterial levels, it could potentially reduce ammonia-affected diseases (e.g., air sacculitis) or bacterial diseases (e.g., cellulitis), resulting in a monetary gain for producers.…”

Section: Description Of Problemmentioning

confidence: 99%

Effect of adding ozone into an intensive broiler production unit on performance, mortality, ammonia levels, and bacterial levels as compared with a non-ozone-treated broiler unit

Schwean-Lardner

Dahiya

Olkowski

et al. 2009

Journal of Applied Poultry Research

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Ozone is a very unstable and reactive molecule that can rapidly oxidize many organic substances and is often used for odor control. It is also known to be an effective biocide at high dose levels. Despite the lack of scientific evidence linking ozone to reduced aerial ammonia at levels that are safe for birds and humans, there is still an interest in the use of the product for commercial production poultry units. The objective of this experiment was to determine the effect of adding atmospheric ozone at a target level of 0.05 ppm (level achieved, 0.03 ± 0.017 ppm) to rooms housing broiler chickens. Female broiler chickens were grown in either an untreated environment or an environment with added ozone (3 rooms of 5 replicate pens, each containing 110 birds/treatment). Bird weight and feed consumption were recorded on a pen basis at 21 and 40 d of age; mortalities were collected daily, and necropsies were performed. Air samples were collected and plated on appropriate media to count total aerobic bacteria at 11, 19, and 34 d of age and enterobacteria at 34 d. Atmospheric ammonia levels were measured on d 15, 20, 28, 32, and 38. A significant (P ≤ 0.05) improvement in feed conversion (feed:gain ratio) when corrected for mortality was noted in the ozone-treated birds (1.808 vs. 1.870). Birds exposed to ozone grew significantly slower (1.938 vs. 2.053 kg of BW gain), consumed less feed (3.695 vs. 3.953 kg), and had a higher mortality (11.46 vs. 7.33%) and condemnation percentages (10.36 vs. 3.39%) than nontreated broilers. The addition of ozone caused no significant decrease in ammonia level or total bacterial count. The major increases in morbidity and mortality of the birds subjected to ozone make ozone gas unacceptable for use in a commercial broiler unit and raise serious health issues for both producers and birds.

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Section: Description Of Problemmentioning

confidence: 99%

Effect of adding ozone into an intensive broiler production unit on performance, mortality, ammonia levels, and bacterial levels as compared with a non-ozone-treated broiler unit

Schwean-Lardner

Dahiya

Olkowski

et al. 2009

Journal of Applied Poultry Research

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Cardiovascular Effects of Ozone Exposure in Human Volunteers

Gong

Wong

Sarma

et al. 1998

Am J Respir Crit Care Med

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We hypothesized that ozone (O3) exposure acutely affects cardiovascular hemodynamics in humans and, in particular, in subjects with essential hypertension. We studied 10 nonmedicated hypertensive and six healthy male adults. Each subject, after catheterization of the right heart and a radial artery, was exposed in an environmentally controlled chamber to filtered air (FA) on one day and to 0.3 ppm O3 on the following day for 3 h with intermittent exercise. Relative to FA exposure, O3 exposure induced no statistically significant changes in cardiac index, ventricular performance, pulmonary artery pressure, pulmonary and systemic vascular resistances, ECG, serum cardiac enzymes, plasma catecholamines and atrial natriuretic factor, and SaO2. The overall results did not indicate major acute cardiovascular effects of O3 in either the hypertensive or the control subjects. However, mean preexposure to postexposure changes were significantly (p < 0.02) larger with O3 than with FA for rate-pressure product (1,353 beats/min/mm Hg) and for heart rate (8 beats/min); these responses were not significantly different between the hypertensive and the control subjects. Significant O3 effects were also observed for mean FEV1 (-6%), and AaPO2 (> 10 mm Hg increase), which were not significantly different between the two groups. These results suggest that O3 exposure can increase myocardial work and impair pulmonary gas exchange to a degree that might be clinically important in persons with significant preexisting cardiovascular impairment, with or without concomitant lung disease.

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Variation in echocardiographic and cardiac hemodynamic effects of PM and ozone inhalation exposure in strains related toNppaandNpr1gene knock-out mice

Tankersley

Peng

Bedga

et al. 2010

Inhalation Toxicology

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Elevated levels of ambient co-pollutants are associated with adverse cardiovascular outcomes shown by epidemiology studies. The role of particulate matter (PM) and ozone (O3) as co-pollutants in this association is unclear. We hypothesize that cardiac function following PM and O3 exposure is variably affected by genetic determinants (Nppa and Npr1 genes) and age. Heart function was measured before and after 2 days each of the following exposure sequence; (1) 2-h filtered air (FA) and 3-h carbon black (CB; 0.5 microg/m(3)); (2) 2-h O3 (0.6 ppm) and 3-h FA; (3) 5-h FA; and, (4) 2-h O3 and 3-h CB. Two age groups (5 and 18 months old (mo)) were tested in C57Bl/6J (B6) and 129S1/SvImJ (129) mice using echocardiographic (echo) and in vivo hemodynamic (IVH) measurements. With echo, posterior wall thickness was significantly (P < 0.01) greater in 129 relative to B6 mice at baseline. With CB exposure, young B6 and older 129 mice show significant (P < 0.01) reductions in fractional shortening (FS) compared to FA. With O3 exposure, FS was significantly (P < 0.01) diminished in young 129, which was attributable to significant increases in end-systolic left ventricular diameter. With O3 and CB combined, notable (P < 0.01) declines in heart rate and end-systolic posterior wall thickness occurred in young 129 mice. The IVH measurements showed striking (P < 0.05) compromises in cardiac function after CB and O3 exposure; however, strain differences were undetectable. These results suggest that PM and O3 exposures, alone and combined, lead to different cardiac functional changes, and these unique changes are age-specific and dependent on Nppa and Npr1 genes.

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Ozone Increases Atrial Natriuretic Peptides in Heart, Lung and Circulation of Aged vs. Adult Animals

Cited by 5 publications

References 26 publications

Effect of adding ozone into an intensive broiler production unit on performance, mortality, ammonia levels, and bacterial levels as compared with a non-ozone-treated broiler unit

Effect of adding ozone into an intensive broiler production unit on performance, mortality, ammonia levels, and bacterial levels as compared with a non-ozone-treated broiler unit

Cardiovascular Effects of Ozone Exposure in Human Volunteers

Variation in echocardiographic and cardiac hemodynamic effects of PM and ozone inhalation exposure in strains related toNppaandNpr1gene knock-out mice

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