Ozone‐induced grafting of a sulfoammonium zwitterionic polymer onto low‐density polyethylene film for improving hemocompatibility

Abstract

Ozone-induced grafting was developed to improve the hemocompatibility of biomaterials based on low-density polyethylene (LDPE). An LDPE film was activated with ozone and graft-polymerized with N,NЈ-dimethyl-(methacryloylethyl)ammonium propane sulfonate (DMAPS). The existence of sulfobetaine structures on the grafted film was confirmed by X-ray photoelectron spectroscopy and attenuated total reflection/Fourier transform infrared (ATR-FTIR). More DMAPS was grafted onto the LDPE film as the DMAPS concentration increased, as determined by ATR-FTIR. Static contact-angle measurements indicated that the DMAPSgrafted LDPE film had a significant increase in hydrophilicity. The blood compatibility of the grafted film was preliminarily evaluated with a platelet-rich-plasma (PRP) adhesion study. No platelet adhesion was observed on the grafted film incubated with PRP at 37°C for 180 min. This new sulfoammonium zwitterionic-structure-grafted biomaterial might have potential for biomedical applications.

Structures and Synthesis of Zwitterionic Polymers

“…In particular, the latter profits from the facile incorporation of reactive groups in special positions, e.g., in the center or at the ends of the polymers, that enable efficient attachment of the macromolecules onto the substrates. Still, classical grafting-from [318][319][320][321][322][323][324][325][326][327][328][329][330][331][332][333][334][335], grafting-to [336][337][338][339][340][341][342][343][344][345][346], and grafting-through [316,347] procedures are of course continuously in use, especially in industrial applications, where the activation of the surfaces for the grafting process by physical means or by simple, "unpretentious" chemistry is preferred for reasons of experience, cost and high-throughput.…”

In Commodity Plastics

“…A platelet -rich plasma adhesion study showed that no platelet adhesion occurred on the grafted LDPE fi lms when the fi lms were maintained at 37 ° C for 180 min. The grafting technique and protocol shows promise for use in biomedical applications [8] .…”

Surface modification of polyurethane via covalent immobilization of sugar-based trisiloxane surfactants

“…[11][12][13][14][15][16] Among these methods, photochemical treatment induced by UV irradiation is the most promising approach for its fast reaction rate, low cost of processing, simple equipment, and easy industrialization. [17] What's more, it is an effective way to directly immobilize various biocompatible moieties, such as poly(ethylene glycol), [18,19] poly(N-vinyl pyrrolidone), [20] heparin, [21,22] phospholipid polymer, [23][24][25] chitosan, [26][27][28] glycopolymers, [29] and hyaluronic acid [15] onto the surface of a substrate to obtain a target performance.…”