Ozone-induced neurotoxicity: In vitro and in vivo evidence

Singh S., Ankul; Suresh, Swathi; Vellapandian, Chitra

doi:10.1016/j.arr.2023.102045

Cited by 16 publications

(6 citation statements)

References 130 publications

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“…The interaction of O 3 with organic substrates containing double bonds leads to the formation of ozonides, which further leads to the formation of hydroperoxides. Thus, as O 3 is not a radical species, it functions by inducing the formation of RONS [ 63 ]. In this context, direct and indirect processes occur during the formation of RONS by O 3 .…”

Section: Nitrooxidative Stress By Omentioning

confidence: 99%

“…The most studied transcriptional factors upon exposure to O 3 are Nrf2, NFκB, MAPK, and NLRP3. The OS caused by O 3 triggers the activation of these important signaling pathways, and the consequences of their activation are closely related to the development of neurodegenerative diseases [ 63 ]. There is clear evidence that O 3 induces activation of NFκB through the activation of IKK by RONS [ 11 , 79 , 80 ].…”

Section: Transcriptional Factors Activated By Omentioning

confidence: 99%

“…This scenario resembles the physiopathology of AD [ 76 ]. The neurodegenerative changes including the increased concentration of oxidized and nitrosylated biomolecules (membrane phospholipids, carbohydrates, proteins, DNA, RNA), mitochondrial dysfunction, misfolded protein accumulation, endoplasmic reticulum stress, apoptosis, and so on, coincides with a cellular response to a harmful condition that leads to neuronal death [ 63 , 77 , 87 ]. These changes are behaviorally reflected as memory loss, cognitive decline, locomotor impairment, as well as neuropsychiatric symptoms like apathy, anxiety, and depression [ 88 , 89 ].…”

Section: Brain Damage By Omentioning

confidence: 99%

“…Microglial activation implies the acquisition of phagocytic activity with increased production of RONS and secretion of inflammatory cytokines. These changes are meant to be beneficial to the neuronal tissue; however, under chronic activation, they become harmful [ 63 , 101 , 102 ].…”

Section: Neurodegenerative Markers Induced By Omentioning

confidence: 99%

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Nitrooxidative Stress and Neuroinflammation Caused by Air Pollutants Are Associated with the Biological Markers of Neurodegenerative Diseases

Ramírez-Mendoza,

Mendoza-Magaña,

Ramírez-Herrera

et al. 2024

Antioxidants

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Millions of people around the world are exposed to air pollutants, such as particulate matter 2.5 (PM2.5) and ozone (O3). Such exposure usually does not exclude these two types of pollutants and their harmful effects could be additive or synergistic. O3 is a highly oxidizing gas that reacts with the cellular environment just as PM2.5, triggering nitrooxidative damage. Once nitrooxidative stress overcomes the endogenous antioxidant system, an acute neuroinflammatory process is generated, and once it becomes chronic, it favors the formation of neurodegenerative disease markers. The presence of these markers becomes potentially dangerous in people who have a genetic predisposition and are at a higher risk of developing neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Our experimental approach for nitrooxidative damage and neuroinflammation caused by air pollutants has focused on the exposure of rats to O3 in an isolated chamber. The hippocampus is the most studied brain structure because of its neuronal connectivity network with the olfactory epithelium, its weak antioxidant defense, and its fundamental roll in cognitive processes. However, other brain structures may exhibit a different degree of damage upon exposure to O3 and PM2.5, making their involvement an important factor in developing other CNS diseases. The age spectrum for augmented sensibility to air pollutants seems to mostly affect the pre-postnatal (autism spectrum) period and the elderly (neurodegenerative). Thus, a new approach could be the estimation of the damage caused by PM2.5 and O3 through a controlled exposure paradigm to determine the extent of damage caused by both pollutants.

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Section: Nitrooxidative Stress By Omentioning

confidence: 99%

Section: Transcriptional Factors Activated By Omentioning

confidence: 99%

Section: Brain Damage By Omentioning

confidence: 99%

Section: Neurodegenerative Markers Induced By Omentioning

confidence: 99%

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Nitrooxidative Stress and Neuroinflammation Caused by Air Pollutants Are Associated with the Biological Markers of Neurodegenerative Diseases

Ramírez-Mendoza,

Mendoza-Magaña,

Ramírez-Herrera

et al. 2024

Antioxidants

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“…Hence reduction in ACh levels is a critical element in disorders that cause memory loss, such as AD. Memory-related illnesses are impacted by the alteration of ACh equilibrium at neuronal junctions in the brain brought on by OP pesticides ( 67 ). Recognizing and investigating the correlation between OP exposure and neurodevelopmental outcomes and behavioral effects will promote advancements in the regulation and management of OPs in agricultural, industrial, and domestic settings globally.…”

Section: Environmental Risk Factorsmentioning

confidence: 99%

Alzheimer’s disease: the role of extrinsic factors in its development, an investigation of the environmental enigma

Suresh,

Singh S,

Rushendran

et al. 2023

Front. Neurol.

Self Cite

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In the realm of Alzheimer’s disease, the most prevalent form of dementia, the impact of environmental factors has ignited intense curiosity due to its substantial burden on global health. Recent investigations have unveiled these environmental factors as key contributors, shedding new light on their profound influence. Notably, emerging evidence highlights the detrimental role of various environmental contaminants in the incidence and progression of Alzheimer’s disease. These contaminants encompass a broad spectrum, including air pollutants laden with ozone, neurotoxic metals like lead, aluminum, manganese, and cadmium, pesticides with their insidious effects, and the ubiquitous presence of plastics and microplastics. By meticulously delving into the intricate web connecting environmental pollutants and this devastating neurological disorder, this comprehensive chapter takes a deep dive into their involvement as significant risk factors for Alzheimer’s disease. Furthermore, it explores the underlying molecular mechanisms through which these contaminants exert their influence, aiming to unravel the complex interactions that drive the pathogenesis of the disease. Additionally, this chapter proposes potential strategies to mitigate the detrimental effects of these environmental contaminants on brain health, with the ultimate goal of restoring and preserving typical cognitive function. Through this comprehensive exploration, we aim to enhance our understanding of the multifaceted relationship between neurotoxins and Alzheimer’s disease, providing a solid foundation for developing innovative in-vivo models and advancing our knowledge of the intricate pathological processes underlying this debilitating condition.

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Prospective Intergenerational Consequences of Paternal Stress Experiences on Offspring Immune Health

Guerrin,

Trompke,

Pang

2024

Epigenetics in Biological Communication

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Ozone-induced neurotoxicity: In vitro and in vivo evidence

Cited by 16 publications

References 130 publications

Nitrooxidative Stress and Neuroinflammation Caused by Air Pollutants Are Associated with the Biological Markers of Neurodegenerative Diseases

Nitrooxidative Stress and Neuroinflammation Caused by Air Pollutants Are Associated with the Biological Markers of Neurodegenerative Diseases

Alzheimer’s disease: the role of extrinsic factors in its development, an investigation of the environmental enigma

Prospective Intergenerational Consequences of Paternal Stress Experiences on Offspring Immune Health

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