Ozone therapy for skin diseases: Cellular and molecular mechanisms

Liu, Liyao; Zeng, Liyue; Gao, Lihua; Zeng, Jinrong; Lu, Jianyun

doi:10.1111/iwj.14060

Cited by 38 publications

(14 citation statements)

References 112 publications

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“…Several beneficial effects of O 3 are widely described in the literature, i.e., antibacterial, antifungal, and antiviral properties [ 2 , 3 ]. The anti-inflammatory, analgesic, immunomodulatory, and healing properties have also been reported [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

In Vitro Antiviral and Virucidal Activity of Ozone against Feline Calicivirus

Catella,

Pellegrini,

Carbonari

et al. 2024

Animals

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The Caliciviridae family includes several viral pathogens of humans and animals, including norovirus (NoV), genus Norovirus, and feline calicivirus (FCV), genus Vesivirus. Due to their resistance in the environment, NoV and FCV may give rise to nosocomial infections, and indirect transmission plays a major role in their diffusion in susceptible populations. A pillar of the control of viruses resistant to an environment is the adoption of prophylaR1.6ctic measures, including disinfection. Since NoVs are not cultivatable in common cell cultures, FCV has been largely used as a surrogate of NoV for the assessment of effective disinfectants. Ozone (O3), a molecule with strong oxidizing properties, has shown strong microbicidal activity on bacteria, fungi, protozoa, and viruses. In this study, the virucidal and antiviral activities of an O3/O2 gas mixture containing O3 were tested at different concentrations (20, 35, and 50 μg/mL) for distinct contact times against FCV. The O3/O2 gas mixture showed virucidal and antiviral activities against FCV in a dose- and contact time-dependent fashion. Ozonation could be considered as a valid strategy for the disinfection of environments at risk of contamination by FCV and NoV.

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Section: Discussionmentioning

confidence: 99%

In Vitro Antiviral and Virucidal Activity of Ozone against Feline Calicivirus

Catella,

Pellegrini,

Carbonari

et al. 2024

Animals

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show abstract

“…The concentration and duration of ozone exposure must be carefully regulated to avoid potential adverse effects. 115 While there is promising research suggesting the rejuvenating and reparative properties of ozone, further studies are needed to establish its efficacy, safety, and optimal applications in different settings. Consulting with medical or skincare professionals who have expertise in ozone treatment can provide more specific information and guidance based on the most current research and best practices.…”

Section: Ozone In Tissue Remodelling and Rejuvenationmentioning

confidence: 99%

“…The concentration and duration of ozone exposure must be carefully regulated to avoid potential adverse effects. 115…”

Section: Introductionmentioning

confidence: 99%

Ozone in the adjunct medical treatment. The round personality of a molecule with hormetic properties

Chirumbolo,

Tirelli,

Franzini

et al. 2023

Hum Exp Toxicol

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Ozone, an allotrope of oxygen, is enjoying an increasing interest in the setting and management of the medical adjunct treatment, which is called, maybe too simplistically, “ozone therapy”. Ozone is not a medicine, so the word therapy does not properly fit this gaseous molecule. Like many natural compounds, for example plant flavonoids, even ozone interacts with aryl hydrocarbon receptors (AhRs) and, at low doses, it works according to the paradoxical mechanism of hormesis, involving mitochondria (mitohormesis). Ozone, in the hormetic range, exerts cell protective functions via the Nrf2-mediated activation of the anti-oxidant system, then leading to anti-inflammatory effects, also via the triggering of low doses of 4-HNE. Moreover, its interaction with plasma and lipids forms reactive oxygen species (ROS) and lipoperoxides (LPOs), generally called ozonides, which are enabled to rule the major molecular actions of ozone in the cell. Ozone behaves as a bioregulator, by activating a wide population of reactive intermediates, which usually target mitochondria and their turnover/biogenesis, often leading to a pleiotropic spectrum of actions and behaving as a tuner of the fundamental mechanisms of survival in the cell. In this sense, ozone can be considered a novelty in the medical sciences and in the clinical approach to pharmacology and medical therapy, due to its ability to target complex regulatory systems and not simple receptors.

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“…Ozone (O 3 ), a highly reactive oxidant molecule, affects various processes, including immunomodulation, inflammation, antioxidant activity, antibacterial responses, and epigenetic modifications, as well as analgesic, biosynthetic, and vasodilative functions. It also acts as a modulator of regenerative pathways [ 17 - 19 ]. Based on these properties, ozone has been used as a complementary therapy for several cutaneous diseases such as acne, wound healing, psoriasis, diabetic foot, and pressure ulcers [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

“…It also acts as a modulator of regenerative pathways [ 17 - 19 ]. Based on these properties, ozone has been used as a complementary therapy for several cutaneous diseases such as acne, wound healing, psoriasis, diabetic foot, and pressure ulcers [ 17 ]. In addition, ozone therapy has the advantage of being a non-invasive and cost-effective treatment [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Ozonated Sunflower Oil (OSO) Alleviates Inflammatory Responses in Oxazolone-Induced Atopic Dermatitis (AD)-Like Mice and LPS-Treated RAW 264.7 Cells

Kim,

Lee,

Lee

et al. 2024

J. Microbiol. Biotechnol.

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Ozone, a highly reactive oxidant molecule, is widely used as a complementary therapy for various skin diseases, including wound healing, pressure ulcers, diabetic foot, and infections. However, there is limited research on the effectiveness of ozone for atopic dermatitis (AD). Ozonated sunflower oil (OSO) is an active ingredient obtained from partially ozonated sunflower oil (SO). OSO markedly reduced the LPS-induced increase in IL-1β and nitric oxide (NO) levels in RAW 264.7 mouse macrophage cells. Oxazolone (OXZ) was applied to hairless mice to induce AD-like skin symptoms and immune response. OSO significantly alleviated the OXZ-induced increases in the number of infiltrating mast cells, epidermal thickness, AD symptoms, thymic stromal lymphopoietin (TSLP), and filaggrin, as well as the serum levels of NO, IgE, IL-1β, and TNF-α. Furthermore, OSO inhibited the IL-4/STAT3/MAPK pathway and the expression of NF-κB. Our results suggest that OSO treatment could relieve AD-mediated skin damage through its anti-inflammatory and antioxidant activities. Therefore, it can be used as a therapeutic agent against AD-related skin diseases.

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Ozone therapy for skin diseases: Cellular and molecular mechanisms

Cited by 38 publications

References 112 publications

In Vitro Antiviral and Virucidal Activity of Ozone against Feline Calicivirus

In Vitro Antiviral and Virucidal Activity of Ozone against Feline Calicivirus

Ozone in the adjunct medical treatment. The round personality of a molecule with hormetic properties

Ozonated Sunflower Oil (OSO) Alleviates Inflammatory Responses in Oxazolone-Induced Atopic Dermatitis (AD)-Like Mice and LPS-Treated RAW 264.7 Cells

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