Ozonolysis of cyclomusalenone and its derivatives

Synthesis and evaluation of 29-norcycloartane triterpenoids as α-glucosidase inhibitors

“…Substances were detected by a 10 % solution of sulfuric acid solution with subsequent heating at 100-120°C for 2-3 min. The extraction of cyclomusalenone 1 and synthesis of compounds 3-6 are described in (Smirnova et al, 2012).…”

“…Compounds 3-6 which are synthesized earlier (Smirnova et al, 2012) and new derivatives 2, 7, 8 were investigated on inhibitory activity toward a-glucosidase.…”

One-pot Synthesis of Hollongdione from Dipterocarpol

“…As part of our ongoing program on the synthesis of novel biologically active derivatives of natural metabolites using oxidation reactions [16,[21][22][23][24][25][26][27], and considering the high pharmacological potential of dammarans, we report here a one-pot synthesis of hollongdione (3) -a hybrid triterpenoid-steroid molecule, from dipterocarpol (1). Hollongdione is a crucial intermediate in the synthesis of the potent immunosuppessive agent 17α-23-(E)-dammara-20,23-diene-3β,25-diol [20].…”

Synthesis of new A-conjugated Quinolone and Spiroindole Dammaranes by the Ozonolysis of 2,3-Indolodipterocarpol

“…As a part of our ongoing program on the synthesis of novel biologically active derivatives of natural metabolites using oxidation reactions [5,[16][17][18][19][20], we report herein an access to new quinolone and spiroindole dammaranеs by the oxidation of 2,3indolodipterocarpol 1 with ozone. Taking into consideration the mechanism of ozonolysis by side chain of dipterocarpol in protic and aprotic solvents led to various products [5], we carried out the oxidation of 2,3-indolodipterocarpol 1 in AcOH and CH 2 Cl 2 .…”