. Oсumethyl in the treatment of allergic diseases of eyelids and conjunctiva

Abstract

Treatment of allergic diseases of eyelids and conjunctiva (conjunctivites and blepharoconjunctivites) often presents difficulties due to peculiarities of their pathogenesis - allergic and vascular reactions, disorder of lacrimal production, meibomian gland dysfunction, and possible bacterial contamination. It has been suggested to use Ocumethyl, which contains zinc sulfate (binding, drying, anti-inflammatory, and antiseptic effect), diphenhydamine hydrochloride (an Н1-antihistamine that decreases capillary permeability and helps resolve conjunctival and eyelid edema), naphazoline hydrochloride (a sympathomimetic notable for its strong, rapid, and long-lasting vasoconstrictive effect), and methylene blue (antiseptic effect, disintoxication, and antioxidant activity). A total of 80 patients with chronic allergic conjunctivitis, blepharoconjuntivitis, or giant papillary conjunctivitis associated with contact lens wearing were treated with Ocumethyl instillations (3 times daily for 15-30 days). A clinically significant effect was obtained in 77-91% of patients depending on the disease entity.

Methylene Blue Inhibits Acute Hemorrhagic Conjunctivitis Virus Production and Induction of Caspase-3 Mediated Human Corneal Cell Cytopathy

“… 27 Nonprescription topical ophthalmic medications containing MB are commonly used internationally for various complaints of ocular discomfort and redness. Marchenko 34 reported a clinically significant effect with an ophthalmic solution containing zinc sulfate, diphenhydramine hydrochloride, naphazoline hydrochloride, and MB (300 ng/mL) in patients with chronic allergic conjunctivitis, blepharo-conjunctivitis, or contact lens induced giant papillary conjunctivitis following treatment (3 times daily for 15–30 days). Brownstein et al 35 reported 6 patients with a spectrum of adverse ocular reactions, following prolonged daily use (4 months to 8 years) of nonprescription topical ophthalmic medication composed of MB, naphazoline hydrochloride or nitrate, and amylocaine hydrochloride, that were presumably due to at least one of the ingredients.…”