P-01-063 Intraoperative Injection of (99mm)Tc-nanocolloid for Localization of Nonpalpable Intratesticular Tumours in Organ-sparing Surgery

Dominguez, Joaquin; Servio, L. Ibarz; Manuel, Gatica; Perisé, O. Calaf

doi:10.1016/j.jsxm.2016.03.214

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The optimal method of detecting SLN is the use of colloid nanomaterials labeled with technetium-99m for scintigraphic or radiometric determination of node localization 6 – 13 . Not so much the chemical nature of such particles but their size is the determining factor in the choice of the indicator in this case.…”

Section: Introductionmentioning

confidence: 99%

99mTc-labeled nanocolloid drugs: development methods

Sadkin

Скуридин

Нестеров

et al. 2020

Sci Rep

View full text Add to dashboard Cite

The work considers the problem of obtaining nanocolloid radiopharmaceuticals (RPs) and studying their functional suitability for diagnosing sentinel lymph nodes (SLN) in cancer patients. Two principal approaches to the formation of technetium-99m-labeled particles based on inorganic and organic matrices were considered when carrying out research to develop methods for the production of nanocolloid RPs. The composition of the reagents and the conditions for obtaining nanocolloid radiopharmaceuticals were determined. The functional suitability of new RPs for scintigraphic diagnostics of sentinel lymph nodes has been studied. The identification of sentinel lymph nodes-the first nodes that stand in the way of metastasizing of malignant neoplasms attracts increasing interest in modern oncological practice 1-5. It is believed that if the SLN is not affected by the metastatic process, then all other regional lymph nodes are intact, so the results of biopsy of these nodes are an objective diagnostic criterion for the spread of malignant process (Fig. 1). The optimal method of detecting SLN is the use of colloid nanomaterials labeled with technetium-99m for scintigraphic or radiometric determination of node localization 6-13. Not so much the chemical nature of such particles but their size is the determining factor in the choice of the indicator in this case. Thus, according to Schauer 14 , a colloid with a particle size of less than 50 nm can accumulate not only in the SLN, but also at nodes of 2 and 3 orders of magnitude. Particles with the sizes of more than 100 nm slowly migrate from the injection site. The colloid with the particle size from 50 to 80 nm was recognized as the optimal one for detecting SLN. The simplest method of obtaining colloids with given sizes and properties is immobilization of 99m Tc on the surface of nanosized materials. Technetium-99m is by far the most popular radionuclide for conducting diagnostic studies, practically in all fields of medicine 15-18. This is primarily due to its nuclear-physical characteristics: a relatively short half-life (6.02 h) and γ-radiation energy of 0.1405 meV, providing a low exposure dose and, at the same time, sufficient penetrating power for radiometric measurements. Today, the Tc-99m Tilmanocept radiopharmaceutical is widely used, which has proven itself well and gives good results. But its production is quite time-consuming and requires expensive components. We offer a less laborious method from the simple components 19,20. Materials and methods Materials. All the reagents were purchased from Sigma-Aldrich ACS grade and used without further purification. Technetium-99m was obtained from chromatographic 99 Mo/ 99m Tc generator " 99m Tc-GT-TOM" produced by Tomsk Polytechnic University (TPU)-Tomsk, Russia. Three types of nanoparticles were selected to obtain nanocolloids labeled with 99m Tc. The first type of colloids was created on the basis of metal chelates with chemically modified complexons of diethylenetriaminepentaacetic acid (DTPA). It should be noted tha...

show abstract

Section: Introductionmentioning

confidence: 99%