P.04.7 Prevalence of De Novo Metabolic Syndrome and Its Risk Factors in a Liver Transplanted Population: A Prospective Study

Becchetti, Chiara; Zeni, N.; Ferrarese, Alberto; Zanetto, Alberto; Sciarrone, S.S.; Shalaby, Sarah; Pellone, M.; Ruzzarin, Alessandro; Gambato, M.; Russo, F.P.; Senzolo, Marco; Bassi, D.; Cillo, U.; Burra, P.; Germani, Giacomo

doi:10.1016/s1590-8658(19)30344-5

Cited by 1 publication

(2 citation statements)

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“…Non‐modifiable risk factors for allograft steatosis and/or NASH include age, genetics, sex and pre‐existing cardiovascular diseases. Female sex is a possible risk factor for steatosis after transplant but features of MS were found to be more frequent in males in an Italian cohort of LT recipients 129 . Furthermore, male patients presented a significantly lower survival rate when transplanted for metabolic disease compared with female patients in a European study 123 ; however, this results still need to be confirmed in other cohorts before an accurate interpretation can be drawn.…”

Section: Nash As Indication For Liver Transplantationmentioning

confidence: 94%

“…Female sex is a possible risk factor for steatosis after transplant but features of MS were found to be more frequent in males in an Italian cohort of LT recipients. 129 Furthermore, male patients presented a significantly lower survival rate when transplanted for metabolic disease compared with female patients in a European study 123 ; however, this results still need to be confirmed in other cohorts before an accurate interpretation can be drawn. Besides sex differences, a recent meta-analysis examining 17 studies, representing 2,378 post-LT patients, found the 5-year incidence rates for recurrent NAFLD to be 82% and the rate of cirrhosis from 1% to 11%.…”

Section: Long-term Post-transplant Complicationsmentioning

confidence: 94%

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Clinical impact of sexual dimorphism in non‐alcoholic fatty liver disease (NAFLD) and non‐alcoholic steatohepatitis (NASH)

Burra

Bizzaro

Gonta

et al. 2021

Liver International

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NAFLD/NASH is a sex‐dimorphic disease, with a general higher prevalence in men. Women are at reduced risk of NAFLD compared to men in fertile age, whereas after menopause women have a comparable prevalence of NAFLD as men. Indeed, sexual category, sex hormones and gender habits interact with numerous NAFLD factors including cytokines, stress and environmental factors and alter the risk profiles and phenotypes of NAFLD. In the present review, we summarized the last findings about the influence of sex on epidemiology, pathogenesis, progression in cirrhosis, indication for liver transplantation and alternative therapies, including lifestyle modification and pharmacological strategies. We are confident that an appropriate consideration of sex, age, hormonal status and sociocultural gender differences will lead to a better understanding of sex differences in NAFLD risk, therapeutic targets and treatment responses and will aid in achieving sex‐specific personalized therapies.

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Section: Nash As Indication For Liver Transplantationmentioning

confidence: 94%

Section: Long-term Post-transplant Complicationsmentioning

confidence: 94%