P-061. Hard to believe, hardly discussed, nevertheless very important for the IVF/ICSI results: embryo transfer technique can double or halve the pregnancy rate

Impact of embryo replacement depth on in vitro fertilization and embryo transfer outcomes

“…This was obviously the effect of previously mentioned studies, as most studies investigating the best site for embryo transfer suggested that embryo transfer high in the endometrial cavity near the fundal endometrial surface were associated with lower PRs (2,(9)(10)(11)(12)(16)(17)(18)(19). We conclude that these data influenced our choice for the site of embryo transfer.…”

“…Clinical PRs varied significantly between the two groups and it was 27.7% in group A and 14% in group B (P<.05). In addition to these recent and well-known studies, other studies proved higher implantation rates when embryos were placed at lower levels in the uterine cavity (2,(16)(17)(18)(19).…”

The Role of Ultrasound in the Evaluation of Endometrial Receptivity Following Assisted Reproductive Treatments

“…Later this finding was also substantiated by Naaktgeboren (1998). By applying a technique in which the embryos are expelled at a fixed distance from the external os, a remarkable decrease was observed in the variability in success rates among physicians: most physicians approximated the success rates of the best-performing physician (Naaktgeboren et al, 1997(Naaktgeboren et al, , 1998. The wide variability between clinicians working in the same center (which to an extent nullifies the potential difference in the laboratory circumstances) clearly demonstrates the role of the clinician in embryo transfer and the magnitude of problem.…”

“…Waterstone et al (1991) suggested that the site of deposition of the embryos within the uterine cavity could have profound effects on success rates. Later this finding was also substantiated by Naaktgeboren (1998). By applying a technique in which the embryos are expelled at a fixed distance from the external os, a remarkable decrease was observed in the variability in success rates among physicians: most physicians approximated the success rates of the best-performing physician (Naaktgeboren et al, 1997(Naaktgeboren et al, , 1998.…”

“…Whereas some investigators believe that higher levels in the endometrial cavity closer to the uterine fundus lead to higher rates (Krampl et al, 1995;Meldrum et al, 1987 ), others have suggested that improved embryo transfer results are obtained when the embryos are placed at lower levels in the uterine cavity (Coroleu et al, 2002a;Frankfurteret al, 2003;Lesny et al, 1998;Naaktgeboren et al, 1997;Naaktgeboren et al, 1998;Van de Pas et al, 2003;Waterstone et al, 1991;Woolcott and Stanger, 1997;). Waterstone et al (1991) reported the results of embryo transfer performed by two clinicians who followed different techniques.…”