P.0644 Validation and factor structure of the Patient Health Questionnaire-9 in individuals with anxiety and mood disorders in Lithuania

Stanytė, Agnė; Steiblienė, Vesta; Podlipskytė, Aurelija; Gečaitė-Stončienė, Julija; Macijauskienė, Jūratė; Burkauskas, Julius

doi:10.1016/j.euroneuro.2021.10.608

Cited by 1 publication

(1 citation statement)

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“…GAD‐7 cut‐off scores ≥8 or ≥10 were also discussed, but discarded because absolute scores do not account for initial disease severity. Some panelists argued that the GAD‐7 should not be used as the sole measure for treatment failure in GAD, as some studies failed to define a cut‐off score with adequately balanced sensitivity and specificity for GAD 74‐76 , or reported that the GAD‐7 had good sensitivity and specificity for any anxiety disorders, but low specificity for GAD 77 .…”

Section: Resultsmentioning

confidence: 99%

The definition of treatment resistance in anxiety disorders: a Delphi method‐based consensus guideline

Domschke,

Seuling,

Schiele

et al. 2024

World Psychiatry

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Anxiety disorders are very prevalent and often persistent mental disorders, with a considerable rate of treatment resistance which requires regulatory clinical trials of innovative therapeutic interventions. However, an explicit definition of treatment‐resistant anxiety disorders (TR‐AD) informing such trials is currently lacking. We used a Delphi method‐based consensus approach to provide internationally agreed, consistent and clinically useful operational criteria for TR‐AD in adults. Following a summary of the current state of knowledge based on international guidelines and an available systematic review, a survey of free‐text responses to a 29‐item questionnaire on relevant aspects of TR‐AD, and an online consensus meeting, a panel of 36 multidisciplinary international experts and stakeholders voted anonymously on written statements in three survey rounds. Consensus was defined as ≥75% of the panel agreeing with a statement. The panel agreed on a set of 14 recommendations for the definition of TR‐AD, providing detailed operational criteria for resistance to pharmacological and/or psychotherapeutic treatment, as well as a potential staging model. The panel also evaluated further aspects regarding epidemiological subgroups, comorbidities and biographical factors, the terminology of TR‐AD vs. “difficult‐to‐treat” anxiety disorders, preferences and attitudes of persons with these disorders, and future research directions. This Delphi method‐based consensus on operational criteria for TR‐AD is expected to serve as a systematic, consistent and practical clinical guideline to aid in designing future mechanistic studies and facilitate clinical trials for regulatory purposes. This effort could ultimately lead to the development of more effective evidence‐based stepped‐care treatment algorithms for patients with anxiety disorders.

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Section: Resultsmentioning

confidence: 99%