P-1-18 Cortical and subcortical brain changes in bipolar affective disorders: a magnetic resonance imaging study

Cerebral white matter lesions in bipolar affective disorder: relationship to outcome

“…In bipolar subjects, T 2 -weighted magnetic resonance imaging (MRI) has revealed deep subcortical white matter lesions (DWML) and periventricular white matter lesions (PVWML), which have differing neuropathologies (Fazekas et al , 1993). Although not all MRI studies find an excess of white matter lesions (Brown et al , 1992; Strakowski et al , 1993), the majority do (Dupont et al , 1987, 1990, 1995 a , b ; Swayze et al , 1990; Figiel et al , 1991; McDonald et al , 1991; Puzynski et al , 1995; Woods et al , 1995), and meta-analysis indicates that more bipolar patients than controls exhibit WMLs (Altshuler et al , 1995). Specific, but as yet unidentified subgroups, may exhibit WMLs.…”