P.1.d.013 Prenatal stress increases an anxiety, and alters corticosterone response to 5-HT2A/C agonist in adult female offspring

Ordyan, N. É.; Pivina, S. G.; Shamolina, T. S.; Fedotova, Julia

doi:10.1016/s0924-977x(09)70435-3

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“…This type of stress exposure induces signifi cant psychoemotional disturbances (increased anxiety, and depressive behavior) and impairments of learning abilities in the progeny of exposed pregnant female rats, which are followed by the signifi cant changes in the activity of hormonal systems [3,7,10]. The control group included intact pregnant females (n=5).…”

Section: Methodsmentioning

confidence: 99%

Effects of Prenatal Stress on the Activity of the Pituitary-Ovarian System in Female Rats

2013

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The comparative analysis of hormonal status was performed in mature female rats with experimental deficiency of estrogens, which mothers were exposed to stress during pregnancy. High levels of follicle-stimulating hormone and luteinizing hormone, and significantly lower amount of estradiol were observed in intact prenatally stressed females in comparison with intact non-stressed female rats. The increase in the levels of follicle-stimulating hormone and luteinizing hormone, and the decrease in estradiol concentration were more pronounced in blood serum of prenatally stressed ovariectomized rats as distinct from intact non-stressed and prenatally stressed female rats, and non-stressed ovariectomized female rats. We can conclude that prenatally stressed ovariectomized rats were characterized by an increased sensitivity to exogenous hormonal interventions and high lability of functional state of the pituitary-ovarian system.

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Section: Methodsmentioning

confidence: 99%