P.1.i.015 Serum folate, vitamin B12, and homocysteine in acute patients with schizophrenia, depression, or bipolar disorder

Trujillo, Francisca; Raya, J.M.; Monzón, J.; Rodriguez-Martos, T.; Salinas, Marcelo; Martín‐Santos, Taida; Sangines, M.; Henry, Maria Aparecida Coelho Arruda; Jiménez-Sosa, Alejandro; Gracia, R.

doi:10.1016/s0924-977x(09)70521-8

Cited by 3 publications

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“…4 A study made with 70 Spanish psychiatric inpatients in 2009 also showed significantly lower levels of folate in patients when compared with controls. 5 A meta-analysis published in 2007 showed a significant relationship between folate status and depression, which remained after controlling for potential confounding factors -age, nutritional status and co-morbid alcohol disorders. 6 A meta-analysis published in 2016 showed that folate deficiency is associated with schizophrenia diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Níveis de Ácido Fólico numa Amostra de Doentes Psiquiátricos Portugueses em Ambulatório

Lopes

2018

Gaz Med

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INTRODUCTION:There is substantial evidence of the association between mental disorders and low folic acid levels. The aim of this study was to evaluate the prevalence of folic acid deficiency in a sample of Portuguese psychiatric outpatients. METHODS: The study was retrospective and included 428 psychiatric outpatients with a diagnosis of depression or non-affective psychosis, for whom folic acid levels had been measured as part of routine blood tests. Folic acid levels from other hospital patients from the same time period were also registered. RESULTS AND DISCUSSION: The prevalence of folic acid deficiency in this sample is 18%. Non-psychiatric hospital patients with risk factors for folic acid deficiency have a prevalence of 15% of folic acid deficiency. Men and younger patients have lower folic acid levels, with statistical significance, and the prevalence of deficit reached 26%. CONCLUSION: The elevated frequency of folic acid deficiency in this sample of patients shows that folic acid levels should be routinely assessed in every patient with depression or psychosis, in order to avoid maintenance of symptoms and treatment resistance.

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Section: Introductionmentioning

confidence: 99%

Níveis de Ácido Fólico numa Amostra de Doentes Psiquiátricos Portugueses em Ambulatório

Lopes

2018

Gaz Med

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Serum folate levels in schizophrenia: A meta-analysis

Wang

Zhai

Liu

2016

Psychiatry Research

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Comparison of Serum Folate between Schizophrenic Patients and Healthy Controls in Chinese Han Adult Population: A Systematic Review and Meta-Analysis

Wang

Zhai

Liu

2023

CCHTS

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Aim and Objective: To assess the relationship between serum folate and schizophrenia (SZ) risk in Chinese Han adult population in different papers, the systematic review and meta-analysis was conducted. Materials and Methods: We searched for this meta-analysis on three English databases (PubMed, Embase, and Web of science) and four Chinese databases (CNKI, SinoMed, Wanfang, and CQVIP) in March 27, 2021. Inclusion criteria: studies provided folate levels in serum of cases and controls as mean and standard deviation. Exclusion criteria: subjects were not Chinese Han adult population. The Newcastle-Ottawa Scale score was done to assess risk of bias in the included studies. Standard mean difference was used to measure the difference between SZ patients and healthy controls. Subgroup analyses by measurement time, duration, and age were performed, respectively. Results: This meta-analysis was included 19 publications involving 1571 SZ cases and 1283 healthy controls. In total studies, the pooled result showed that SZ patients had the decreased serum folate levels compared with healthy controls (SMD [95%CI] = -1.37[-1.83,-0.90], PSMD<0.001), and most of the subgroups, the associations were also reached decreased significant; while in the subgroup of drug using, the association was not reached significantly. Conclusion: Dose-response analysis and subgroup analyses by gender were not performed for the lack of the data. Folate deficiency is associated with the patients, and antipsychotic drugs might have positive effects on improving serum folate levels in Chinese Han adult SZ.

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P.1.i.015 Serum folate, vitamin B12, and homocysteine in acute patients with schizophrenia, depression, or bipolar disorder

Cited by 3 publications

References 0 publications

Níveis de Ácido Fólico numa Amostra de Doentes Psiquiátricos Portugueses em Ambulatório

Níveis de Ácido Fólico numa Amostra de Doentes Psiquiátricos Portugueses em Ambulatório

Serum folate levels in schizophrenia: A meta-analysis

Comparison of Serum Folate between Schizophrenic Patients and Healthy Controls in Chinese Han Adult Population: A Systematic Review and Meta-Analysis

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