P.12.22 Marked Activation of Mucosal Pro-Inflammatory Immune Response in Diverticulitis but Not in Diverticulosis

Biancheri, Paolo; Sabatino, Antonio Di; Kok, Klaartje; Giuffrida, Paolo; Guerci, M.; Salvatore, C.; Massari, Angelo; Pasini, Anna Maria Fratta; Ubezio, C.; Macdonald, T.T.; Corazza, G.R.

doi:10.1016/s1590-8658(13)60511-3

Cited by 1 publication

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“…Consequently, a comprehensive evaluation of the full texts of the remaining 25 articles for eligibility assessment was conducted. Of these, 13 articles were excluded due to the following reasons: (1) 2 were case reports [ 26 , 27 ]; (2) 4 were conference abstracts [ 28 , 29 , 30 , 31 ]; (3) 3 were letters [ 32 , 33 , 34 ]; and (4) 4 were literature reviews [ 13 , 35 , 36 , 37 ]. The overall number of included articles in the qualitative synthesis was 12 studies, among which 6 were included in the quantitative synthesis [ 15 , 17 , 18 , 19 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ].…”

Section: Resultsmentioning

confidence: 99%

Section: Summary Measure and Synthesis Of Resultsmentioning

confidence: 99%

“…Analysis was performed when at least two studies assessed similar groups and revealed the same outcome via mean and SD, or median (IQR) of the TNF-α levels. (1) 2 were case reports [26,27]; (2) 4 were conference abstracts [28][29][30][31]; (3) 3 were letters [32][33][34]; and (4) 4 were literature reviews [13,[35][36][37]. The overall number of included articles in the qualitative synthesis was 12 studies, among which 6 were included in the quantitative synthesis [15,[17][18][19][38][39][40][41][42][43][44][45].…”

Section: General Resultsmentioning

confidence: 99%

“…Throughout the screening stage, 152 articles were excluded for the following reasons: (1) 39 were irrelevant articles; (2) 53 were literature reviews; (3) 2 were experimental studies; (4) 6 were editorials and letters; (5) 18 were conference abstracts; (6) 6 were guidelines; (7) 22 were books/chapters; (8) 4 were case reports; and (9) 2 were published in other languages.Consequently, a comprehensive evaluation of the full texts of the remaining 25 articles for eligibility assessment was conducted. Of these, 13 articles were excluded due to the following reasons: (1) 2 were case reports[26,27]; (2) 4 were conference abstracts[28][29][30][31];(3) 3 were letters[32][33][34]; and (4) 4 were literature reviews[13,[35][36][37]. The overall number of included articles in the qualitative synthesis was 12 studies, among which 6 were included in the quantitative synthesis[15,[17][18][19][38][39][40][41][42][43][44][45].…”

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confidence: 99%

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Do Colonic Mucosal Tumor Necrosis Factor Alpha Levels Play a Role in Diverticular Disease? A Systematic Review and Meta-Analysis

Sabo

Ismaiel

et al. 2023

IJMS

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Diverticular disease (DD) is the most frequent condition in the Western world that affects the colon. Although chronic mild inflammatory processes have recently been proposed as a central factor in DD, limited information is currently available regarding the role of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α). Therefore, we conducted a systematic review and meta-analysis aiming to assess the mucosal TNF-α levels in DD. We conducted a systematic literature search using PubMed, Embase, and Scopus to identify observational studies assessing the TNF-α levels in DD. Full-text articles that satisfied our inclusion and exclusion criteria were included, and a quality assessment was performed using the Newcastle–Ottawa Scale (NOS). The principal summary outcome was the mean difference (MD). The results were reported as MD (95% confidence interval (CI)). A total of 12 articles involving 883 subjects were included in the qualitative synthesis, out of which 6 studies were included in our quantitative synthesis. We did not observe statistical significance related to the mucosal TNF-α levels in symptomatic uncomplicated diverticular disease (SUDD) vs. the controls (0.517 (95% CI −1.148–2.182)), and symptomatic vs. asymptomatic DD patients (0.657 (95% CI −0.883–2.196)). However, the TNF-α levels were found to be significantly increased in DD compared to irritable bowel disease (IBS) patients (27.368 (95% CI 23.744–30.992)), and segmental colitis associated with diverticulosis (SCAD) vs. IBS patients (25.303 (95% CI 19.823–30.784)). Between SUDD and the controls, as well as symptomatic and asymptomatic DD, there were no significant differences in the mucosal TNF-α levels. However, the TNF-α levels were considerably higher in DD and SCAD patients than IBS patients. Our findings suggest that TNF-α may play a key role in the pathogenesis of DD in specific subgroups and could potentially be a target for future therapies.

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