P-132 * Bronchial Sleeve Resection or Pneumonectomy for Non-Small-Cell Lung Cancer: A Propensity Matched Analysis of Long-Term Survival and Quality of Life

Andersson, Saana; Ilonen, Ilkka; Räsänen, Jari; Sihvo, Eero; Salo, Jarmo A.

doi:10.1093/icvts/ivu167.132

Cited by 10 publications

(12 citation statements)

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“…However, expanded resection, such as pneumonectomy, did not improve prognosis over lobectomy in our study. Similar findings were reported by Anderson et al (27), who analyzed the 5-year survival rate of 641 patients with T4 NSCLC. Although they found no significant difference in survival between patients who underwent two different types of surgery, patients who underwent lobectomy did not die after 5 years.…”

Section: Discussionsupporting

confidence: 89%

The Positive Lymph Node Ratio Predicts Survival in T1−4N1−3M0 Non-Small Cell Lung Cancer: A Nomogram Using the SEER Database

2020

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Background: An increasing number of studies have shown that the positive lymph node ratio (pLNR) can be used to evaluate the prognosis of non-small cell lung cancer (NSCLC) patients. To determine the predictive value of the pLNR, we collected data from the Surveillance, Epidemiology, and End Results (SEER) database and performed a retrospective analysis. Methods: We collected survival and clinical information on patients with T 1−4 N 1−3 M 0 NSCLC diagnosed between 2010 and 2016 from the SEER database and screened them according to inclusion and exclusion criteria. X-tile software was used to obtain the best cutoff value for the pLNR. Then, we randomly divided patients into a training set and a validation set at a ratio of 7:3. Pearson's correlation coefficient, tolerance and the variance inflation factor (VIF) were used to detect collinearity between variables. Univariate and multivariate Cox regression analyses were used to identify significant prognostic factors, and nomograms was constructed to visualize the results. The concordance index (C-index), calibration curves, and decision curve analysis (DCA) were used to assess the predictive ability of the nomogram. We divided the patient scores into four groups according to the interquartile interval and constructed a survival curve using Kaplan-Meier analysis. Results: A total of 6,245 patients were initially enrolled. The best cutoff value for the pLNR was determined to be 0.55. The nomogram contained 13 prognostic factors, including the pLNR. The pLNR was identified as an independent prognostic factor for both overall survival (OS) and cancer-specific survival (CSS). The C-index was 0.703 (95% CI, 0.695-0.711) in the training set and 0.711 (95% CI, 0.699-0.723) in the validation set. The calibration curves and DCA also indicated the good predictability of the nomogram. Risk stratification revealed a statistically significant difference among the four groups of patients divided according to quartiles of risk score. Conclusion: The nomogram containing the pLNR can accurately predict survival in patients with T 1−4 N 1−3 M 0 NSCLC.

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Section: Discussionsupporting

confidence: 89%

The Positive Lymph Node Ratio Predicts Survival in T1−4N1−3M0 Non-Small Cell Lung Cancer: A Nomogram Using the SEER Database

2020

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“…Quality of life and functional outcomes play an important role for the patients faced to various treatment options in case of lung cancer. Analyses of quality of life are in favor of sleeve resections compared to pneumonectomy (41,42). Furthermore, sleeve lobectomy was favored with regard to quality-adjusted life years in a meta-analysis with 99 investigated studies comparing pneumonectomy to sleeve resections (43).…”

Section: Outcomes Of Sleeve Resectionsmentioning

confidence: 99%

Standard and extended sleeve resections of the tracheobronchial tree

Bölükbas¹,

Baldes²,

Bergmann³

et al. 2020

J Thorac Dis

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Anatomic resections with bronchial and/or vascular resections and reconstruction, so called sleeve resections were originally performed in patients with impaired cardio-pulmonary reserves. Nowadays, sleeve resections are established surgical procedures of first choice for tracheobronchial pathologies, whenever anatomically and oncologically feasible. Experienced thoracic surgeons have a broad surgical armentarium to avoid a pneumonectomy and the morbidity and mortality associated with it. Sleeve resections are associated with better outcomes in all aspects. Thus, sleeve resection is not an alternative for pneumonectomy and vice versa. In this review article we set out to provide a contemporary overview on this topic.

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“…However, bronchoplastic procedures are now standard in patients with centrally located tumors. Accumulating evidence supports that bronchoplastic procedures produce similar oncologic results with significantly lower mortality and less reduction of respiratory function than pneumonectomy [19][20][21][22][23]. Shi and colleagues [24] performed a metaanalysis and reported that bronchoplastic procedures offered lower mortality and better long-term survival than pneumonectomy without increasing loco-regional recurrences.…”

Section: Commentmentioning

confidence: 99%

Prognostic Differences in Subgroups of Patients With Surgically Resected T3 Non-Small Cell Lung Cancer

Jeon

Kim

Moon

et al. 2016

The Annals of Thoracic Surgery

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P-132 * Bronchial Sleeve Resection or Pneumonectomy for Non-Small-Cell Lung Cancer: A Propensity Matched Analysis of Long-Term Survival and Quality of Life

Cited by 10 publications

References 0 publications

The Positive Lymph Node Ratio Predicts Survival in T1−4N1−3M0 Non-Small Cell Lung Cancer: A Nomogram Using the SEER Database

The Positive Lymph Node Ratio Predicts Survival in T1−4N1−3M0 Non-Small Cell Lung Cancer: A Nomogram Using the SEER Database

Standard and extended sleeve resections of the tracheobronchial tree

Prognostic Differences in Subgroups of Patients With Surgically Resected T3 Non-Small Cell Lung Cancer

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