P-165 Specific changes in fecal microbiota may differentiate Pancreatic Cancer patients from healthy individuals

Half, Elizabeth E.; Keren, Nirit; Dorfman, Tatiana; Reshef, Lea; Lachter, I.; Kluger, Yoram; Konikoff, Fred M.; Gphna, U.

doi:10.1093/annonc/mdv233.165

Cited by 12 publications

(6 citation statements)

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“…The putative biomarkers identified in this study, such as V. dispar and the genus Sutterella ( Figure 6 ), may provide additional targets to enhance the dosage response to conventional chemotherapeutic cocktails and simultaneously reduce side effects. In particular, the genera Sutterella , was found to be enriched in pancreatic cancer patients in comparison to control group ( Half et al, 2015 ). Although V. dispar has been recorded as infectious bacterial species for human ( Bhatti and Frank, 2000 ), there is no direct link reported between this species and cancer.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Microbiota in Patients Treated by Surgery or Chemotherapy by 16S rRNA Sequencing Reveals Potential Biomarkers for Colorectal Cancer Therapy

Deng

Guan

et al. 2018

Front. Microbiol.

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Colorectal cancer (CRC) is the third most diagnosed cancer worldwide due to its high difficulty in early diagnosis, high mortality rate and short life span. Recent publications have demonstrated the involvement of the commensal gut microbiota in the initiation, progression and chemoresistance of CRC. However, this microbial community has not been explored within CRC patients after anti-cancer treatments. To this end, we performed next generation sequencing-based metagenomic analysis to determine the composition of the microbiota in CRC patients after anti-cancer treatments. The microbial 16S rRNA genes were analyzed from a total of 69 fecal samples from four clinical groups, including healthy individuals, CRC patients, and CRC patients treated with surgery or chemotherapy. The findings suggested that surgery greatly reduced the bacterial diversity of the microbiota in CRC patients. Moreover, Fusobacterium nucleatum were shown to confer chemoresistance during CRC therapy, and certain bacterial strains or genera, such as the genus Sutterella and species Veillonella dispar, were specifically associated with CRC patients who were treated with chemotherapeutic cocktails, suggesting their potential relationships with chemoresistance. These candidate bacterial genera or strains may have the ability to enhance the dosage response to conventional chemotherapeutic cocktails or reduce the side effects of these cocktails. A combination of common CRC risk factors, such as age, gender and BMI, identified in this study improved our understanding of the microbial community and its compositional variation during anti-cancer treatments. However, the underlying mechanisms of these microbial candidates remain to be investigated in animal models. Taken together, the findings of this study indicate that fecal microbiome-based approaches may provide additional methods for monitoring and optimizing anti-cancer treatments.

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Section: Discussionmentioning

confidence: 99%

Comparison of Microbiota in Patients Treated by Surgery or Chemotherapy by 16S rRNA Sequencing Reveals Potential Biomarkers for Colorectal Cancer Therapy

Deng

Guan

et al. 2018

Front. Microbiol.

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“…Investigations of fecal samples from patients with newly diagnosed pancreatic cancer revealed a higher abundance of Bacteroides, Verrucomicrobia, Sutterella, Veillonella, Odoribacter, and Akkermansia, and lower levels of Firmicutes and Actinobacteria, as compared with healthy subjects [467]. In another study, selective enrichment of Proteobacteria, Synergistetes, and Euryarchaeota in fecal samples of patients with PDAC was observed [468].…”

Section: Cancers Of Digestive Systemmentioning

confidence: 92%

Human Gut Microbiota: Friend or Foe?

Pliszka¹,

Szablewski²

2020

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The human gut is a house to approximately 1,000 different species of bacteria. The bacterial composition of gut microbiota is influenced by several factors, including age, sex, mode of delivery, geographical location, ethnicity, diet, drugs, and administration of prebiotics and/or probiotics. Similarly, human health depends on the composition of gut microbiome, with gut bacteria playing a crucial role in human physiology. For instance, gut microbiota synthesizes vitamins and amino acids, and affects the biotransformation of bile acid. Intestinal microbiota produces short-chain fatty acids (SCFAs) that stimulate intestinal gluconeogenesis, protect the host from diet-induced obesity, and may play a role as an energy substrate. Changes in the composition of gut microbiota, termed dysbiosis, due to, for example, change in the diet or uptake of certain drugs, may result in metabolic diseases, autoimmune and allergic diseases, cancers, and many others. Conversely, dysbiosis can be a consequence of a disease in several cases. This review outlines the current knowledge of the associations between human gut microbiota and human health and diseases.

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“…Pushalkar et al, found that the relative abundance of Proteobacteria, Synergistetes, and Euryachaeota was significantly higher in the feces of patients with PDAC than in their healthy controls [38]. A small study conducted by Half et al, presented at a conference in Israel, highlights that the feces of patients with PC had higher levels of Sutterela, Veillonela, Bacteroides, Odoribacter, and Akkermansia than that of healthy controls [46]. Another study by Half et al found that patients with PC had decreased levels of genera belonging to Firmicutes in their feces [47].…”

Section: Gutmentioning

confidence: 99%

“…Thomas and Jobin suggest that a potential explanation for this may lie in the close association of the pancreatic head with the duodenum, thus being the first site exposed to translocating bacteria [81]. In addition to retrograde translocation through the GI tract, Mitsuhashi et al outline a series of studies which suggest that some bacteria (namely F. nucleatum) may reach the pancreas via circulation [46].…”

Section: Translocationmentioning

confidence: 99%

Microbial Associations with Pancreatic Cancer: A New Frontier in Biomarkers

Stasiewicz

Kwaśniewski

Karpiński

2021

Cancers

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Pancreatic cancer (PC) remains a global health concern with high mortality and is expected to increase as a proportion of overall cancer cases in the coming years. Most patients are diagnosed at a late stage of disease progression, which contributes to the extremely low 5-year survival rates. Presently, screening for PC remains costly and time consuming, precluding the use of widespread testing. Biomarkers have been explored as an option by which to ameliorate this situation. The authors conducted a search of available literature on PubMed to present the current state of understanding as it pertains to the use of microbial biomarkers and their associations with PC. Carriage of certain bacteria in the oral cavity (e.g., Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Streptococcus sp.), gut (e.g., Helicobacter pylori, Synergistetes, Proteobacteria), and pancreas (e.g., Fusobacterium sp., Enterobacteriaceae, Pseudomonadaceae) has been associated with an increased risk of developing PC. Additionally, the fungal genus Malassezia has likewise been associated with PC development. This review further outlines potential oncogenic mechanisms involved in the microbial-associated development of PC.

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P-165 Specific changes in fecal microbiota may differentiate Pancreatic Cancer patients from healthy individuals

Cited by 12 publications

References 0 publications

Comparison of Microbiota in Patients Treated by Surgery or Chemotherapy by 16S rRNA Sequencing Reveals Potential Biomarkers for Colorectal Cancer Therapy

Comparison of Microbiota in Patients Treated by Surgery or Chemotherapy by 16S rRNA Sequencing Reveals Potential Biomarkers for Colorectal Cancer Therapy

Human Gut Microbiota: Friend or Foe?

Microbial Associations with Pancreatic Cancer: A New Frontier in Biomarkers

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