P.17.13 White Mulberry Supplementation as Adjuvant Treatment of Obesity

Ianiro, Gianluca; Toma, E. Dal; Vitale, Anna Rita; Martino, S; Gigante, G.; Cammarota, Giovanni; Gasbarrini, G.; Gasbarrini, A.; Villa, G.

doi:10.1016/s1590-8658(14)60368-6

Digestive and Liver Disease

2014

DOI: 10.1016/s1590-8658(14)60368-6

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P.17.13 White Mulberry Supplementation as Adjuvant Treatment of Obesity

Gianluca Ianiro¹,

E. Dal Toma²,

Anna Rita Vitale³

et al.

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Plant Materials for the Production of Functional Foods for Weight Management and Obesity Prevention

Stabnikova

Paredes‐López

2024

CNF

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Background: Obesity is a serious problem in the modern world and is considered a risk factor in the development of many human diseases. Results: Consumption of low-calorie, low-fat diets, together with increased physical activity and a healthy lifestyle, contribute a lot to the fight against obesity. Meanwhile, functional foods with a reduced calorie content and enriched with substances useful for the human body may play a role as additional helpers in weight management. In this review, general suggestions for the elaboration of foods with plant-origin functional ingredients for weight management, which help the human body with obesity prevention, based on human clinical trials, are proposed. Conclusion: Including new ingredients of plant-origin for the preparation of traditional foods helps to have a balanced diet and may contribute to weight management and obesity prevention.

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Plant Materials for the Production of Functional Foods for Weight Management and Obesity Prevention

Stabnikova

Paredes‐López

2024

CNF

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Bioactive Phytochemicals from Mulberry: Potential Anti-Inflammatory Effects in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages

Lee

Kang

et al. 2021

IJMS

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The fruits of the mulberry tree (Morus alba L.), known as white mulberry, have been consumed in various forms, including tea, beverages, and desserts, worldwide. As part of an ongoing study to discover bioactive compounds from M. alba fruits, the anti-inflammatory effect of compounds from M. alba were evaluated in lipopolysaccharide (LPS)-stimulated mouse RAW 264.7 macrophages. Phytochemical analysis of the ethanol extract of the M. alba fruits led to the isolation of 22 compounds. Among the isolated compounds, to the best of our knowledge, compounds 1, 3, 5, 7, 11, 12, and 14–22 were identified from M. alba fruits for the first time in this study. Inhibitory effects of 22 compounds on the production of the nitric oxide (NO) known as a proinflammatory mediator in LPS-stimulated RAW 264.7 macrophages were evaluated using NO assays. Western blot analysis was performed to evaluate the anti-inflammatory effects of cyclo(L-Pro-L-Val) (5). We evaluated whether the anti-inflammatory effects of cyclo(L-Pro-L-Val) (5) following LPS stimulation in RAW 264.7 macrophages occurred because of phosphorylation of IκB kinase alpha (IKKα), IκB kinase beta (IKKβ), inhibitor of kappa B alpha (IκBα), nuclear factor kappa B (NF-κB) and activations of inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2). Cyclo(L-Pro-L-Val) (5) significantly suppressed phosphorylations of IKKα, IKKβ, IκBα, and NF-κB and activations of iNOS and COX-2 in a concentration-dependent manner. Taken together, these results indicate that cyclo(L-Pro-L-Val) (5) can be considered a potential therapeutic agent for the treatment of inflammation-associated disorders.

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P.17.13 White Mulberry Supplementation as Adjuvant Treatment of Obesity

Cited by 2 publications

References 0 publications

Plant Materials for the Production of Functional Foods for Weight Management and Obesity Prevention

Plant Materials for the Production of Functional Foods for Weight Management and Obesity Prevention

Bioactive Phytochemicals from Mulberry: Potential Anti-Inflammatory Effects in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages

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