P.2.100 Sertindole is superior to haloperidol in cognitive performance in patients with schizophrenia: A comparative study

Lis, Stefanie; Krieger, Stefan H.; Gallhofer, B.; Torre, Paola; Mittoux, Aurélia; Ménard, F.

doi:10.1016/s0924-977x(03)92053-0

Cited by 9 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The effect of sertindole on cognitive function in humans has not been investigated extensively. However, a small clinical trial indicates a beneficial effect on some cognitive substrates in schizophrenic patients (Lis et al 2003).…”

Section: Introductionmentioning

confidence: 99%

Reversal of PCP-induced learning and memory deficits in the Morris’ water maze by sertindole and other antipsychotics

2007

View full text Add to dashboard Cite

These results confirm that repeated PCP administration induces marked cognitive deficits. Further, second-generation antipsychotics like sertindole, clozapine, and risperidone within a certain, often narrow, dose range are able to reverse the impairment and thus might improve cognitive deficits in schizophrenic patients, whereas classical compounds like haloperidol lack this effect. The receptor mechanisms involved in the reversal of PCP's disruptive effect are discussed and likely include a delicate balance between effects on dopamine D(2), 5-HT(2A/6), alpha-adrenergic, muscarinic, and histaminergic H(1) receptors.

show abstract

Section: Introductionmentioning

confidence: 99%

Reversal of PCP-induced learning and memory deficits in the Morris’ water maze by sertindole and other antipsychotics

2007

View full text Add to dashboard Cite

show abstract

“…The previous studies show, that atypical medications contribute to a significant improvement of cognitive function, in contrast to typical medications, which usually lead to deterioration of cognitive abilities [27], [28], [29]. It is important to note that not only medicines affect the cognitive functions, but also the type of disorder is in this respect important.…”

Section: Discussionmentioning

confidence: 97%

Relationship between antipsychotic medication, obesity and cognitive functions

Łopuszańska

Makara-Studzińska

2017

Current Problems of Psychiatry

View full text Add to dashboard Cite

Introduction: The purpose of this study was to examine whether the combination of atypical and typical antipsychotic medications is related with metabolism and cognitive functions in the same manner and degree as taking medications of one kind only, i.e. atypical or typical.Material and methods: The participants of the study comprised of 91 adults with diagnosed mental illness (F-20-F69). The participants were divided into groups on the basis of the kind of administered medications: T+A (typical and atypical medications), A (atypical medications), T (typical medications), P (antidepressants, sedatives, normothymic/antiepileptic drugs). In the study, Short Test of Mental Status (STMS), Verbal Fluency Test (VFT), Rey Auditory Verbal Learning Test (RAVLT) were used for the purpose of examining cognitive functions.Results: The kind of antipsychotic medications taken by the patients did not differentiate the group in relation to BMI (p<0.13), nor in relation to the level of general cognitive function (p<0.72) or verbal fluency (p<0.34). Both atypical antipsychotic medications and the combination of atypical and typical medications were related to the occurrence of abdominal obesity (p<0.01). An increase in waist circumference decreased an ability of abstract reasoning (p<0.005). When it comes to the body mass index, waist circumference negatively correlated with the delayed memory (p< 0.03, p<0.004).Discussion: Both the combination of atypical and typical antipsychotic medications and atypical medications are associated with the occurrence of abdominal obesity. The deposition of fat tissue in the abdomen negatively correlated with an ability to learn.Conclusions: The future studies might explain the interactions between antipsychotic medications, obesity and cognitive function.

show abstract