P.2.a.012 Corticotropin-releasing hormone and corticotropin-releasing hormone receptor 1 mediate acute stress-induced prefrontal cortex dysfunctions

Uribe-Mariño, A.; Solfrank, Beate; Balsevich, Georgia; Santarelli, Sara; Massana, M. Puig; Harbich, D.; Müller, Marianne B.; Schmidt, Mette

doi:10.1016/s0924-977x(14)70587-5

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“…The mPFC-LH pathway was also engaged by acute stressors in this study, a finding that is supported by a known role of the mPFC in integration of acute stress 36,37,38 . This study moves beyond the observation that acute stress increases mPFC activity and illustrates that acute stress recruits the mPFC-LH pathway to suppress food intake and motivation for sucrose pellets.…”

Section: Discussionsupporting

confidence: 84%

Identification of a Stress-Sensitive Anorexigenic Neurocircuit From Medial Prefrontal Cortex to Lateral Hypothalamus

Clarke

Voigt²,

Reichenbach³

et al. 2023

Biological Psychiatry

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Section: Discussionsupporting

confidence: 84%

Identification of a Stress-Sensitive Anorexigenic Neurocircuit From Medial Prefrontal Cortex to Lateral Hypothalamus

Clarke

Voigt²,

Reichenbach³

et al. 2023

Biological Psychiatry

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Identification of a stress-sensitive anorexigenic neurocircuit from medial prefrontal cortex to lateral hypothalamus

Clarke

Voigt

Stark

et al. 2021

Preprint

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Animal models that examine neural circuits controlling food intake often lack translational relevance. To address this limitation, we identified neural network dynamics related to homeostatic state and BMI in humans. This approach predicted a novel pathway projecting from the medial prefrontal cortex (mPFC) to the lateral hypothalamus (LH) in humans. We then dissected the mechanistic underpinnings of this human-relevant mPFC-LH circuit in mice. Chemogenetic or optogenetic activation of the mPFC-LH pathway in mice suppressed food intake and motivated sucrose-seeking. Fibre photometry demonstrated this pathway was active in response to acute stress or prior to novel environment or object exposure, suggesting a role in the predictive assessment of potential threat. Food consumption suppressed mPFC-LH neuronal activity, independent of metabolic state or palatability. Finally, inhibition of this circuit increased feeding and motivated behaviour under mild stress and chronic ablation caused weight gain. These studies identify the mPFC-LH as a novel stress-sensitive anorexigenic neural pathway involved in the cortical control of food intake and motivated reward-seeking.

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P.2.a.012 Corticotropin-releasing hormone and corticotropin-releasing hormone receptor 1 mediate acute stress-induced prefrontal cortex dysfunctions

Cited by 2 publications

References 0 publications

Identification of a Stress-Sensitive Anorexigenic Neurocircuit From Medial Prefrontal Cortex to Lateral Hypothalamus

Identification of a Stress-Sensitive Anorexigenic Neurocircuit From Medial Prefrontal Cortex to Lateral Hypothalamus

Identification of a stress-sensitive anorexigenic neurocircuit from medial prefrontal cortex to lateral hypothalamus

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