P-214 A Study of Fecal Microbiota Transplantation in Pediatric Patients with Inflammatory Bowel Disease

Systematic review with meta‐analysis: faecal microbiota transplantation for the induction of remission for active ulcerative colitis

“…There were 14 cohort studies that included a total of 168 patients (Tables and ). The studies were reported from 2013 until 2017.…”

“…The studies were reported from 2013 until 2017. Three of 14 studies included both UC and Crohn's disease patients, with only the data for UC patients included here. Both paediatric and adult patients were included in the analysis (age range 4.6‐70 years); Follow‐up varied between 1 to 72 months.…”

The Use of Fecal Microbiome Transplant in Treating Human Diseases: Too Early for Poop?

“…A quick search on the clinical trial registry ( ClinicalTrial.gov ) maintained by the United States National Library of Medicine at the National Institutes of Health looking at FMT yielded a total of 242 studies. While several studies celebrated the triumph of FMT, a portion of them reported no significant improvements post-FMT treatments for diseases other than RCDI (attributed to small sample size and characteristics of recruited patients) ( Goyal et al, 2016 ; Aroniadis et al, 2019 ; Saha et al, 2019 ; Yu et al, 2020 ). A randomized clinical trial conducted by Leong and the team explained a difference in microbiome at baseline between FMT donor and obese participant; donor had higher abundance of Akkermansia muciniphila which is known as a beneficial player in metabolism and confers the host protection against metabolic disorders including obesity ( Leong et al, 2020 ; Xu et al, 2020 ).…”

“…Even though there was a shift in microbiome composition among participants post-FMT (which maintained up to 12 weeks), no weight loss was observed in adolescence post-FMT treatment ( Leong et al, 2020 ). At this point in time, more thoughts need to be placed on designing the treatment plan using FMT, including “dose” and method of delivery (oral or enema), alongside with figuring out important microbe(s) in different diseases and their mechanisms to achieve optimal long-term treatment outcome ( Goyal et al, 2016 ; Yu et al, 2020 ).…”

New treatments for ulcerative colitis: do we have pediatric data?

“…Early FMT data delivered by upper gastrointestinal endoscopy and colonoscopy, has recently been reported. [23]. At 6 months 4/7 had shortlived clinical improvement, 2/7 had no response and 1/7 was in remission.…”