P.224 Primary food cues engage pathways involved in over-eating and reward-seeking in rats

Stoltenborg, Iris; Peris-Sampedro, Fiona; May, Marie V. Le; Bake, Tina; Schéle, Erik; Adan, Roger A.H.; Dickson, Suzanne L.

doi:10.1016/j.euroneuro.2019.12.050

Cited by 2 publications

(5 citation statements)

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“…The perforated ball in our study was already present in the home cage prior to single-housing, and all the baseline food intake measurements took place after the PB tastings, in such a way that any contextual cues (i.e., the sudden presence of a new object in the cage or associative contextualization of the home cage with PB intake) could not have influenced the results. In a nutshell, our behavioral approach [ 19 ] allowed us not only to investigate long-term feeding outcomes in response to food-linked olfactory cues with small disturbance to the animals, but also to selectively isolate the cue-dependent effects from the associative learning context, which, per se , influence food intake [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

“…They had ad libitum access to water and chow (2016 Teklad diet, Harlan Laboratories, Cambridgeshire, UK), unless otherwise stated, and were kept under standard conditions of temperature (20 ± 2 °C) and humidity (50 ± 10%) on a 12 h light–dark cycle (lights on at 7:00 a.m.) for the duration of the studies. We used a behavioral preparation [ 19 ], in which a metallic, perforated, opaque tea-strainer ball was suspended from each animal’s cage lid prior to single housing to avoid neophobia (to ensure that the animals were familiar with the set up before each experiment started) and to prevent it from becoming a non-food related contextual cue [ 20 ]. During experiments, this device contained the inaccessible palatable food (peanut butter, PB; Skippy, Hormel foods, Austin, MN, USA), delivering an olfactory cue to the home environment.…”

Section: Methodsmentioning

confidence: 99%

“…In this study, we sought to discover whether a sustained exposure to an olfactory palatable food-evoking cue could increase the intake of a less palatable but readily available food, such as regular chow, in non-food-deprived rats subjected to a home-cage, hidden palatable food paradigm [ 19 ]. As the timing of the cue potentiated feeding effect, if any, remains elusive, we likewise investigated whether it is transient, or whether it persists, and for how long, upon cue presentation.…”

Section: Introductionmentioning

confidence: 99%

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The Orexigenic Force of Olfactory Palatable Food Cues in Rats

et al. 2021

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Environmental cues recalling palatable foods motivate eating beyond metabolic need, yet the timing of this response and whether it can develop towards a less palatable but readily available food remain elusive. Increasing evidence indicates that external stimuli in the olfactory modality communicate with the major hub in the feeding neurocircuitry, namely the hypothalamic arcuate nucleus (Arc), but the neural substrates involved have been only partially uncovered. By means of a home-cage hidden palatable food paradigm, aiming to mimic ubiquitous exposure to olfactory food cues in Western societies, we investigated whether the latter could drive the overeating of plain chow in non-food-deprived male rats and explored the neural mechanisms involved, including the possible engagement of the orexigenic ghrelin system. The olfactory detection of a familiar, palatable food impacted upon meal patterns, by increasing meal frequency, to cause the persistent overconsumption of chow. In line with the orexigenic response observed, sensing the palatable food in the environment stimulated food-seeking and risk-taking behavior, which are intrinsic components of food acquisition, and caused active ghrelin release. Our results suggest that olfactory food cues recruited intermingled populations of cells embedded within the feeding circuitry within the Arc, including, notably, those containing the ghrelin receptor. These data demonstrate the leverage of ubiquitous food cues, not only for palatable food searching, but also to powerfully drive food consumption in ways that resonate with heightened hunger, for which the orexigenic ghrelin system is implicated.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Orexigenic Force of Olfactory Palatable Food Cues in Rats

et al. 2021

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“…Single-housed adult male Sprague-Dawley rats and C57BL/6N mice were used. We used a behavioral preparation firstly developed in our lab (18), in which a metallic, perforated, opaque tea-strainer ball was suspended from each animal's cage lid prior to single housing. During experiments, this device contained the inaccessible palatable food (peanut butter, PB; Skippy, Hormel foods, Austin, MN, USA).…”

Section: Animalsmentioning

confidence: 99%

“…In this study, we sought to discover whether a chronic exposure to an olfactory palatable food-evoking cue can increase the intake of a less palatable but readily available food, such as regular chow, in sated rats subjected to a palatable home-cage hidden-food paradigm (18). Animals were exposed to an olfactory cue-rich environment recalling the palatable food whilst having access exclusively to chow.…”

Section: Introductionmentioning

confidence: 99%

The orexigenic force of olfactory palatable food cues in sated rats

Peris-Sampedro

Stoltenborg

May

et al. 2021

Preprint

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Background: Environmental cues recalling palatable foods are ubiquitous and motivate eating beyond metabolic need, yet the timing of this response and whether it can develop towards a non-palatable readily available food remain elusive. Although there is increasing evidence indicating that external stimuli in the olfactory modality can communicate with the major hub in the feeding neurocircuitry, the hypothalamic arcuate nucleus (Arc), the identity of hypothalamic substrates has been only partially uncovered. Methods: Using a palatable home-cage hidden-food paradigm, we investigate the ability of olfactory food cues to promote chow overconsumption in sated male rats, together with their impact on meal pattern. We likewise explore, by means of an immediate early gene marker, the neural mechanisms involved, including the possible engagement of the orexigenic ghrelin system. Results: Olfactory detection of a familiar palatable food shifts diurnal patterns towards an increase in meal frequency to cause persistent overconsumption of chow in sated conditions. In line with the orexigenic response observed, sensing the palatable food in the environment stimulates food-seeking and risk-taking behavior, and also triggers release of active ghrelin. Olfactory food cues recruit intermingled populations of cells embedded within the feeding circuitry within the Arc, including, notably, those containing the ghrelin receptor, even when food is not available for consumption. Conclusions: These data demonstrate leverage of ubiquitous food cues, not only for palatable food-searching, but also to powerfully drive food consumption in ways that resonate with heightened hunger, for which the orexigenic ghrelin system is implicated.

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P.224 Primary food cues engage pathways involved in over-eating and reward-seeking in rats

Cited by 2 publications

References 0 publications

The Orexigenic Force of Olfactory Palatable Food Cues in Rats

The Orexigenic Force of Olfactory Palatable Food Cues in Rats

The orexigenic force of olfactory palatable food cues in sated rats

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