P-232 Clinical outcomes and characteristics according to localization of colorectal cancer in Fundacion Santa Fe De Bogota between May 2015-May 2019

Abstract

Background: In Colombia, colorectal cancer is the third neoplasm with the most incidence, with 9140 new cases in 2018. The objective of this study is to make a description using real-world data of the characteristics and clinical outcomes of patients according to location, in a cancer reference institution in Colombia.Methods: This is an observational study of a cohort of patients with adenocarcinoma of colon and rectum. We did follow up for 51 months and analyzed molecular, epidemiological and clinical characteristics and overall survival (OSm). We use Kaplan-Meier as survival analysis.Results: Forty patients were included, 42% had left colon cancer, 28% had rectum cancer and 30% right colon cancer. The distribution according to the sex was: left colon 70.5% female/29.5% male, in rectum 45.4% female/54.5% male, In right colon: 33.3% female/66.6% male. The 50% of the patients at the time of diagnosis had a level of CEA less than 5 ng and 25% had a CEA greater than 10ng. There were no differences in age according to location, the average was 60 years. At the time of diagnosis 32.5% were stage IV, 30% stage III, 22.5% stage II, and 10% stage I. The distribution of these stages according to location were: In left colon 38.8% stage IV, 27,7% stage III, 22.2% stage II and 5% stage I, in the rectum 36.3% stage IV, 27.2% stage III, 9% stage II and 27.2% stage I. For the right colon was: 16.6% stage IV, 50% stage III, 33.3% stage II and 0% stage I. In the cohort of patients with metastatic disease, concerning to molecular characteristics, the presence of RAS mutation was found in 50%, BRAF mutation in 7%, high MSI in 18%, and in relation to localization, the right colon had a 100% of RAS mutation, while left colon 28.6%, in rectum was 50% . In the context of advanced disease there was not differences in the average age between right and left colon. In the survival analysis the OSm in stage IV was 16m in right colon cancer vs 27,6m in left colon cancer and in rectum cancer was 21m. According with RAS status, in patients with mutation the OSm was 20m and in wild type 25m. Conclusion:FETs have a favorable prognosis regardless of the histological type and site of occurrence, specifically when managed with successful surgical resection.Legal entity responsible for the study: The author.

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