P-241 – Thrombopénie néonatale allo-immune par immunisation anti-HPA-1b associée à un syndrome hémorragique sévère: À propos d'un cas

Severe intracranial haemorrhage in neonatal alloimmune thrombocytopenia due to antibodies against human platelet antigen 1b: Case report and literature review

“…Sometimes, the second episode of thrombocytopenia can occur 6,26 . In three cases, continuous prolonged thrombocytopenia was noted 20,25,27 . In a case by Moser et al 25 IVIg was indicated on day 48 and 49, while in a case of Hadj et al 27 long‐term corticosteroids were indicated to stabilise platelet count.…”

“…In the seven published cases, thrombocytopenia and signs of bleeding occurred on the first day of life 7,20–24,27 . Three cases reported the first symptoms during the second day of life 25,25,26 .…”

“…As seen with other HPA antigens, immunisation and FNAIT due to anti‐HPA‐1b antibodies sometimes occur during the first pregnancy 6,21,22,27 …”

“…Since the first case report of FNAIT due to anti‐HPA‐1b antibodies was described by Mueller‐Eckhardt et al in 1986, 21 only nine further case reports have been published in the literature (Table 2). 6,7,20,22–27 …”

“…Unlike FNAIT due to anti‐HPA‐1a antibodies, published reports of FNAIT due to anti‐HPA‐1b antibodies documented platelet recovery in infants treated with unselected blood—either exchange transfusion with fresh blood 21,22 or random donor platelet transfusion 6,26,27 . In five cases previously described, infants were treated with IVIg 6,7,25–27 …”