P.3.026 The impact of antipsychotic drugs in depression: a role for adult neurogenesis?

Morais, Mónica; Pinheiro, Andréa Poyastro; Patrício, Patrícia; Alves, Danielle Cristina Leandro; Pinto, L.; Sousa, Nuno Manuel Frade de; Bessa, João M.

doi:10.1016/s0924-977x(14)70086-0

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Psychopharmacology Related To Depression In Myasthenia Gravis1

Recommendations For Clinical Practice1

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2019

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“…Atypical antipsychotics (clozapine) causes an increase in cell proliferation and neurogenesis in the hippocampal dentate gyrus which regulates the HPA axis. 25 Clobazam is a benzodiazepine derivative which is a long acting GABA-A receptor agonist with anxiolytic, sedative and anticonvulsant activity. Clobazam can cause muscle weakness and is contraindicated in patients with MG. 26…”

Section: Psychopharmacology Related To Depression In Myasthenia Gravismentioning

confidence: 99%

“…20 The use of atypical antipsychotics (Clozapine) for depressed patients causes an increase in cell proliferation and neurogenesis in the hippocampal dentate gyrus which regulates the HPA axis but requires routine evaluation because antipsychotic drugs cause disturbances in nerve and muscle nicotinic and muscarinic receptors. 25…”

Section: Recommendations For Clinical Practicementioning

confidence: 99%

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Psychopharmacology in myasthenia gravis patients with focus on depression

2019

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Myasthenia gravis is an autoimmune disease with a potential to disrupt brain function and cause depression as a result of the disease itself or treatment side effect. Some biological and psychological mechanisms have been proposed for the correlations between myasthenia gravis and depression. Depression might present in patients myasthenia gravis, and it might complicate the course of the disease. Adequate treatment might not only improve the depression but might also impact the myasthenia gravis in general.

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Section: Psychopharmacology Related To Depression In Myasthenia Gravismentioning

confidence: 99%

Section: Recommendations For Clinical Practicementioning

confidence: 99%