P.3.b.028 Understanding the impact of persistent symptoms in schizophrenia: cross-sectional findings from the Pattern study

Haro, JM; Altamura, Carlo; Corral, Ricardo; Elkis, Hélio; Evans, John; Malla, A.; Krebs, M.O.; Zink, Mathias; Alberti, Luciano; Bernasconi, Corrado; Lalonde, Jasmin; Nordstroem, Anna-Lena

doi:10.1016/s0924-977x(14)70811-9

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“…This may have a significant impact on the difficulty in detecting the associations of primary negative symptoms with the symptom severity and the level of functioning. It has not proved possible in this analysis to reliably determine whether PNS have a greater impact on the severity of schizophrenia symptomatology and the level of functioning than any other persistent symptoms unresponsive to treatment [26], although some authors indicate their greater prognostic significance [27]. This paper, which has referred only 3 i 7 latach.…”

Section: Dyskusjamentioning

confidence: 94%

“…Ten fakt może mieć znaczący wpływ na trudność wykrycia związków pierwotnych objawów negatywnych z nasileniem objawów oraz poziomem funkcjonowania. Przeprowadzona analiza nie pozwala jednoznacznie rozstrzygnąć, czy PON mają większy wpływ na nasilenie symptomatologii schizofrenii i poziom funkcjonowania niż jakiekolwiek inne, niepoddające się leczeniu, przetrwałe objawy [26], chociaż niektórzy autorzy wskazują na ich większe znaczenie rokownicze [27]. Prezentowana analiza odnosi się jedynie do znaczenia predykcyjnego pierwotnych i wtórnych objawów negatywnych w badanej grupie i wskazuje, że nie ma znaczenia, jaki objaw choroby pozostaje przewlekły i odporny na dotychczasowe sposoby leczenia, gdyż po wielu latach każdy jest niekorzystnym czynnikiem rokowniczym.…”

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Negative syndrome, persistent negative symptoms and deficit syndrome and their associations with severity of clinical symptoms and level of functioning in 20-year schizophrenia

Kalisz¹,

Mętel²,

Daren³

et al. 2020

ppn

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Purpose:The study assessed the associations between negative symptoms measured with the BPRS-WR (Brief Psychiatric Rating Scale -Withdrawal, Retardation), persistent negative symptoms (PNS) and deficit syndrome (DS) with severity of symptoms and level of functioning in 20-year schizophrenia. Methods: Fifty patients diagnosed with schizophrenia according to DSM III were examined during their first psychiatric hospital admission and after 1, 3, 7, 12 and 20 years. The group with the BPRS-WR symptoms was selected on the basis of an evaluation conducted one year after discharge from their first hospitalization. The PNS and DS groups were selected following examinations performed at discharge and one year later. The proxy for deficit syndrome (PDS) method was used to assess DS. Results: A greater severity of negative syndrome and PNS was associated with greater severity of positive symptoms and poorer general functioning at subsequent measurement points. No such associations were found for the DS. A higher BPRS-WR score was the most stable predictor and explainer of a greater severity of positive and negative schizophrenia symptoms and deterioration in subjects' functioning over the 20-year period. This association often weakened as the observation time lengthened. Conclusions: The association of negative symptoms with the severity of the symptoms of schizophrenia and the level of functioning decreased as the criteria eliminating secondary negative symptoms were gradually introduced.

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Section: Dyskusjamentioning

confidence: 94%

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