P.3.c.004 A mechanism of antipsychotic treatment failure and its reversal

Capturing schizophrenia-like prodromal symptoms in a spinocerebellar ataxia-17 transgenic rat

“…Decreased DA levels can impair the DA-mediated autoinhibition and may predispose to DA supersensitivity, leading to psychosis in humans or schizophrenia-like symptoms in animals. Of note, the role of decreased monoamine levels in DA supersensitivity has already been suggested to mediate antipsychotic treatment failure in animal models (Amato, 2015; Amato et al, 2011a, 2011b, 2013, 2014) and in humans (Howes and Kapur, 2014).…”