P 30 Clinical characteristics of patients whose preeclampsia status changes

Persson, Lars-Göran; Lihme, Frederikke; Basit, Saima; Lykke, Jacob Alexander; Andersen, Anita Sylvest; Thorsen-Meyer, Annette; Wohlfahrt, Jan; Boyd, Heather A.

doi:10.1016/j.preghy.2017.07.108

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“…PE is a pregnancy-related hypertensive disorder that affects 3–6% of pregnant women ( 5 ). Clinically, PE is characterized by an elevated blood pressure of above 140/90 mmHg and proteinuria of over 300 mg/day, which is also observed in diabetic patients ( 6 , 7 ). PE is the leading cause of maternal mortality in low- to middle-income countries and has been estimated to affect 2–10% of pregnant women annually ( 8 , 9 ).…”

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confidence: 99%

High-fat, high-carbohydrate diet-induced prediabetes preconception in Sprague–Dawley rats as a risk factor for the development of preeclampsia: assessing changes in placental metabolic insults

Ludidi,

Siboto,

Nkosi

et al. 2023

Front. Nutr.

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IntroductionHyperglycemia preconception deranges the establishment of a functional placenta; however, the risk of developing preeclampsia (PE) in prediabetic patients remains obscure. The aim was to assess abnormal placental changes as a risk factor for the development of PE in high-fat, high-carbohydrate (HFHC) diet-induced prediabetic (PD) rats.MethodsHFHC diet-induced female prediabetic Sprague–Dawley rats were mated, and blood glucose concentrations, mean arterial pressure (MAP), and body weights were monitored on gestational days (GNDs) 0, 9, and 18. On GND 18, animals were euthanized. Blood and placentas were collected for biochemical analysis.ResultsPrediabetic rats showed significantly increased blood glucose concentration, proinflammatory cytokines, MAP, placental weight, and fetoplacental ratio compared with non-prediabetic (NPD) rats. Prediabetic rats showed significantly decreased placental vascular endothelial growth factor receptor 1 (VEGFR1) and placental growth factor (PLGF) and plasma nitric oxide (NO) compared with NPD.DiscussionPrediabetes may have promoted endothelial dysfunction in the placenta and hypoxia, thus reducing PLGF and VEGFR1, which may have promoted proinflammation, endothelial dysfunction associated with NO decline, and hypertension, which is also observed in preeclamptic patients. Prediabetes may have promoted lipogenesis in placentas and fetuses that may have induced macrosomia and IUGR, also observed in preeclamptic patients. The findings from this study highlight the need for screening and monitoring of prediabetes during pregnancy to reduce the risk of developing preeclampsia.

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