P-384 – Les rachitismes vitamino-résistants hypophosphatémiques: À propos de trois cas

Hadj, I. Bel; Kefi, Aykut; Hamouda, S.; Khalsi, F.; Tinsa, Faten; Boussetta, K.

doi:10.1016/s0929-693x(15)30562-5

Archives de Pédiatrie

2015

DOI: 10.1016/s0929-693x(15)30562-5

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P-384 – Les rachitismes vitamino-résistants hypophosphatémiques: À propos de trois cas

I. Bel Hadj¹,

Aykut Kefi²,

S. Hamouda³

et al.

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“…Approximately 20% of neonatal jaundice is attributable to hemolytic disease (HD) of the newborn, and nearly 30% of cases are caused by ABO blood group (ABO) or rhesus (Rh) system incompatibility. 4 As a consequence of the routine immunoprophylaxis with Rh immunoglobulin (Ig), ABO incompatibility is more common; however, less severe than Rh disease. ABO incompatibility occurs in infants with blood group A or B who are born to O group mothers, and it is seen in 15 to 25% of all pregnancies.…”

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confidence: 99%

Positive Direct Antiglobulin Test: Is It a Risk Factor for Significant Hyperbilirubinemia in Neonates with ABO Incompatibility?

et al. 2021

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Objective: ABO incompatibility is a common cause of neonatal indirect hyperbilirubinemia. The direct antiglobulin test (DAT) can identify infants developing hemolytic disease. This study aims to evaluate the significance of DAT positivity among neonates with ABO incompatibility. Study Design: This retrospective study included 820 neonates with blood group A or B who were born to blood group O mothers. The study group consisted of neonates (n = 79) who had positive DAT, and the control group consisted of infants (n = 741) who had negative DAT. Demographic and clinical data of the neonates regarding jaundice were collected and compared statistically. Results: The bilirubin level at 24 hours of life (study group 8 ± 2.6 mg/dl, control group 6 ± 2.2 mg/dl, p < 0.001) and the highest bilirubin level (study group 12.7 ± 3.6 mg/dl, control group 10.4 ± 4.2 mg/dl, p < 0.001) were higher in infants with positive DAT. In the study group 37 (46.8%) infants and in the control group 83 (11.2%) infants received PT in the nursery (p < 0.001). In neonates with positive DAT; direct bilirubin level, duration of hospitalization, and PT in the nursery were higher (p = 0.002, p < 0.001, and p < 0.001), whereas hemoglobin level was lower (p < 0.001). Conclusion: In neonates with ABO incompatibility, a positive DAT is a risk factor for developing significant hyperbilirubinemia. Close follow-up of newborn infants with ABO incompatibility is crucial for early detection and treatment of neonatal jaundice to avoid early and late complications.

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confidence: 99%

Positive Direct Antiglobulin Test: Is It a Risk Factor for Significant Hyperbilirubinemia in Neonates with ABO Incompatibility?

et al. 2021

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P-384 – Les rachitismes vitamino-résistants hypophosphatémiques: À propos de trois cas

Cited by 1 publication

References 0 publications

Positive Direct Antiglobulin Test: Is It a Risk Factor for Significant Hyperbilirubinemia in Neonates with ABO Incompatibility?

Positive Direct Antiglobulin Test: Is It a Risk Factor for Significant Hyperbilirubinemia in Neonates with ABO Incompatibility?

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