P(3HB) Based Magnetic Nanocomposites: Smart Materials for Bone Tissue Engineering

Abstract

The objective of this work was to investigate the potential application of Poly(3-hydroxybutyrate)/magnetic nanoparticles, P(3HB)/MNP, and Poly(3-hydroxybutyrate)/ferrofluid (P(3HB)/FF) nanocomposites as a smart material for bone tissue repair. The composite films, produced using conventional solvent casting technique, exhibited a good uniform dispersion of magnetic nanoparticles and ferrofluid and their aggregates within the P(3HB) matrix. The result of the static test performed on the samples showed that there was a 277% and 327% increase in Young’s modulus of the composite due to the incorporation of MNP and ferrofluid, respectively. The storage modulus of the P(3HB)MNP and P(3HB)/FF was found to have increased to 186% and 103%, respectively, when compared to neat P(3HB). The introduction of MNP and ferrofluid positively increased the crystallinity of the composite scaffolds which has been suggested to be useful in bone regeneration. The total amount of protein absorbed by the P(3HB)/MNP and P(3HB)/FF composite scaffolds also increased by 91% and 83%, respectively, with respect to neat P(3HB). Cell attachment and proliferation were found to be optimal on the P(HB)/MNP and P(3HB)/FF composites compared to the tissue culture plate (TCP) and neat P(3HB), indicating a highly compatible surface for the adhesion and proliferation of the MG-63 cells. Overall, this work confirmed the potential of using P(3HB)/MNP and P(3HB)/FF composite scaffolds in bone tissue engineering.

Polyhydroxyalkanoates (PHA) for therapeutic applications

“…Microbial polyhydroxyalkanoates (PHA) have diverse structures with diverse properties [1,2] including biodegradation, cell and tissue compatibility [3]. Potential application of PHA includes medical implant such as heart valve tissue engineering [4,5], vascular tissue engineering [6,7], bone tissue engineering [8][9][10], cartilage tissue engineering [11,12], nerve conduit tissue engineering [13,14] as well as drug delivery carrier matrix [15,16]. Many of relevant studies have been conducted in the authors' lab in the past 20+ years [17].…”

Green Composites of Poly(3-hydroxybutyrate) Containing Graphene Nanoplatelets with Desirable Electrical Conductivity and Oxygen Barrier Properties

“…15,16 It has a Young’s modulus of 3.5–4.0 GPa and an elongation at break less than 5%. Due to its biocompatibility and biodegradability, P(3HB) is also considered as a promising bioplastic in biomedical applications 10,17−21 and the packaging industry. 22−24…”

Flexible Ferrofluids: Design and Applications

“…With the development of tissue engineering, attention has been attracted to introducing ferromagnetic particles and magnetic forces into this field . In addition to fast‐developing magnetic manipulation, an innovative technology for 3D tissue culture, magnetic biocompatible scaffolds, and magnetically actuated hydrogels have also been synthesized to direct cell organization. A selective summary of ferromagnetic‐particle‐assisted approaches to tissue engineering is given in Table 3 .…”