P.533 The two-injection start of aripiprazole once-monthly provides rapid attainment of therapeutic concentrations without the need for 14-day oral tablet supplementation

Wang, X.; Harlin, Matthew; Wang, Y.; Larsen, Frank; Raoufinia, Arash

doi:10.1016/j.euroneuro.2020.09.388

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2021

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“…The data for PopPK analyses come from 7 clinical trials (n = 817), resulting in 8214 aripiprazole plasma concentrations. 7 Various simulations were performed, and a 2-injection initiation regimen was approved by Health Canada as follows: 2 separate injections of 400 mg AOM at separate injection sites and a single 20 mg dose of oral aripiprazole. PopPK analyses also supplement the product monograph to guide dosing with regards to ethnic origin; smoking status; dosage adjustments for poor metabolizers of CYP2D6 and patients taking concomitant CYP2D6 and/or CYP3A4 inhibitors; and missed doses.…”

mentioning

confidence: 99%

Population pharmacokinetics and dosing of long-acting injectable antipsychotics

Kim

Barr

Rafizadeh

et al. 2021

jpn

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mentioning

confidence: 99%

Population pharmacokinetics and dosing of long-acting injectable antipsychotics

Kim

Barr

Rafizadeh

et al. 2021

jpn

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Schizophrenia and Related Psychoses

2021

The Maudsley Prescribing Guidelines in Psychiatry

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Despite disagreements about nomenclature, patients who develop schizophrenic or schizophrenialike symptoms in later life are often seen in clinical practice. Questions about the etiology of late-life psychotic disorders and about their similarities or differences from early-onset disorders remain unanswered. Neuroimaging techniques have been used to study patients with late onset of psychosis, and in substantial subgroups of patients (from 25% to 100% in various studies) compared with agematched control subjects, structural and functional abnormalities have been found. We review the literature on imaging in late-life schizophrenia and related psychotic disorders, and we present data from our own investigations of patients with these disorders. We discuss the potential usefulness of imaging evaluations in patients with late-onset disorders, and we offer suggestions for future investigations.

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P.533 The two-injection start of aripiprazole once-monthly provides rapid attainment of therapeutic concentrations without the need for 14-day oral tablet supplementation

Cited by 2 publications

References 0 publications

Population pharmacokinetics and dosing of long-acting injectable antipsychotics

Population pharmacokinetics and dosing of long-acting injectable antipsychotics

Schizophrenia and Related Psychoses

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