P.6.d.002 Involvement of amygdaloid and hypothalamic CRF receptors in the reinforcing effects of psychoactive drugs in rats

Shabanov, Petr Dmitriyevich; Лебедев, А. А.; Streltsov, V.F.; Pavlenko, V.P.

doi:10.1016/s0924-977x(08)70819-8

Cited by 4 publications

(7 citation statements)

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“…The amygdala plays a greater role in the reinforcing effect of narcogens than the hypothalamus [2,6,10]. Our recent studies showed that phenamine (1 mg/ kg), morphine (1 mg/kg), and sodium ethaminal (5 mg/kg) differ in their capacity to activate self-stimulation of the lateral hypothalamus in rats (by 18-37%) [2,4,6,10].…”

Section: Resultsmentioning

confidence: 99%

“…Astressin potentiates the inhibitory effect of leu-enkephalin on brain self-stimulation, which is probably associated with transient inhibition of hypothalamic activation by the central amygdaloid nucleus. Hence, astressin-induced blockade of CRH receptors in the amygdala and, particularly, in the hypothalamus abolishes or significantly decreases the reinforcing effect of morphine, sodium ethaminal, and leu-enkephalin (as differentiated from phenamine) [6,10]. The central amygdaloid nucleus (major part of the extended amygdala) probably modulates reinforcing activity of the lateral hypothalamus, which is related to function of extrahypothalamic CRH-containing neurons.…”

Section: Resultsmentioning

confidence: 99%

“…Probably, the hypothalamic mechanisms of reinforcement are less associated with stress-limiting systems of the brain (CRH-ACTH). However, the reinforcing mechanisms of the extended amygdala strongly depend on exogenous and endogenous stress [5,6,9]. The hypothalamus exhibits a similar response to narcogens and, particularly, to sedative drugs (sodium ethaminal, fentanyl, and ethanol).…”

Section: Resultsmentioning

confidence: 99%

“…Electrophoretic visualization of PCR products. Physiological saline (control, 1); phenamine (2); fentanyl (3); ethanol (4); sodium ethaminal (5); and dexamethasone (6).…”

Section: Resultsmentioning

confidence: 99%

“…Our previous experiments showed that the central nucleus of the amygdale, a component of the extended amygdala system, modulates the action of pharmacological agents with narcogenic activity [2,4,6,10]. It should be emphasized that the amygdala triggers the hypothalamic dopaminergic mechanisms of reinforcement [5,10].…”

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confidence: 99%

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Expression of mRNA for corticotropin-releasing hormone and vasopressin in the hypothalamus and amygdala of rats after administration of narcogenic

Shabanov

Lebedev

2008

Bull Exp Biol Med

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Male Wistar rats received intraperitoneal injections of physiological saline (control), phenamine, fentanyl, ethanol, sodium ethaminal, or dexamethasone in increasing concentrations for 4 days. Forced administration of these drugs provided gradual load of the organism and prevented the development of tolerance. Such approach is extensively used for the development of drug addiction or several manifestations of this state. Expression of corticotropin-releasing hormone mRNA in the amygdala was maximum after administration of dexamethasone (0.46 arb. units vs. beta-actin), but was much lower in experiments with sodium ethaminal and fentanyl (0.07 and 0.037 arb. units, respectively). In the hypothalamus, enhanced mRNA expression was observed after injection of sodium ethaminal, ethanol, and fentanyl (0.8, 0.37, and 0.039 arb. units, respectively). Phenamine did not increase mRNA expression in the amygdala and hypothalamus. Expression of vasopressin mRNA was not detectable in brain structures of animals from various groups. Our results indicate that the hypothalamic reinforcement system provides a similar response to narcogens, whereas the extended amygdala includes elements of both reinforcement and stress reactivity.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Electrophoretic visualization of PCR products. Physiological saline (control, 1); phenamine (2); fentanyl (3); ethanol (4); sodium ethaminal (5); and dexamethasone (6).…”

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

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Expression of mRNA for corticotropin-releasing hormone and vasopressin in the hypothalamus and amygdala of rats after administration of narcogenic

Shabanov

Lebedev

2008

Bull Exp Biol Med

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Structural Changes in Mesocorticolimbic Dopaminergic System of the Brain during Long-Term Alcoholization in Rats

2008

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We studied morphofunctional changes in structures of the mesocorticolimbic system of rat brain upon long-term (5 months) ethanol intoxication. Alcoholization reduced the volume and specific density of neurons in the substantia nigra and ventral tegmental area. The density of neurogliocytes in the substantia nigra and ventral tegmental area increased. Neuronal density in the nucleus accumbens and anterior cingulate cortex significantly decreased, the volume of viable neurons slightly increased. One month after alcohol cessation, the volume of neurons in the substantia nigra and ventral tegmental area remained elevated against the background of their reduced density. The density of neuroglia in the nucleus accumbens and anterior cingulate cortex remained at the level observed during alcoholization. Significant decrease in the density and decrease in the volume of neurons in structures of the mesocorticolimbic system accompanied by the increase in neuroglyocyte density in these structures can be considered as morphological signs of long-term alcoholic intoxication, which persist after alcohol cessation.

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Antihypoxants, Thiasolo[5,4-b]Indole Derivatives, Increase Exercise Performance in Rats and Mice

Marysheva

Shabanov

2009

Bull Exp Biol Med

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The actoptrotective activity of 12 new antihypoxants of the thiasolo[5,4-b]indole series was studied on the model of treadmill running until exhaustion 1 and 24 h after intraperitoneal injection. Highly active compounds more effective than the reference drugs bemithyl and phenamine were found. They increased exercise performance 1 or 24 h after injection or maintained high performance throughout 24 h.

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P.6.d.002 Involvement of amygdaloid and hypothalamic CRF receptors in the reinforcing effects of psychoactive drugs in rats

Cited by 4 publications

References 0 publications

Expression of mRNA for corticotropin-releasing hormone and vasopressin in the hypothalamus and amygdala of rats after administration of narcogenic

Expression of mRNA for corticotropin-releasing hormone and vasopressin in the hypothalamus and amygdala of rats after administration of narcogenic

Structural Changes in Mesocorticolimbic Dopaminergic System of the Brain during Long-Term Alcoholization in Rats

Antihypoxants, Thiasolo[5,4-b]Indole Derivatives, Increase Exercise Performance in Rats and Mice

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