P.7.b.012 Testosterone and explosive aggression in children with autism spectrum disorders

Pivovarciova, Anna; Hnilicova, Silvia; Tomova, Aleksandra; Ostatníková, Daniela; Mace, F. Charles

doi:10.1016/s0924-977x(14)71148-4

Cited by 7 publications

(3 citation statements)

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“…mouse model with elevated aggression and exercise was found to ameliorate aggressive behavior through activation of the reeling signaling pathway [Seo et al, 2013]. Aggressive behaviors are common in many neurological and psychiatric disorders including neurodegenerative disorders [Burns et al, 1990;Fisher et al, 2014;Oh et al, 2015], developmental disabilities [Rojahn et al, 1993], schizophrenia [Sandyk, 1993], bipolar disorder [Ballester et al, 2012], ADHD [Cha et al, 2015],and autism [Pivovarciova et al, 2014]. Epidemiologic and molecular genetic studies show that many disorders share genetic variants in common, suggesting common underlying molecular mechanisms [de Lacy and King, 2013;Lichtenstein et al;Smoller et al, 2013].…”

Section: Figmentioning

confidence: 99%

Genetic architecture for human aggression: A study of gene–phenotype relationship in OMIM

Zhang-James

Faraone

2015

American J of Med Genetics Pt B

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Genetic studies of human aggression have mainly focused on known candidate genes and pathways regulating serotonin and dopamine signaling and hormonal functions. These studies have taught us much about the genetics of human aggression, but no genetic locus has yet achieved genome‐significance. We here present a review based on a paradoxical hypothesis that studies of rare, functional genetic variations can lead to a better understanding of the molecular mechanisms underlying complex multifactorial disorders such as aggression. We examined all aggression phenotypes catalogued in Online Mendelian Inheritance in Man (OMIM), an Online Catalog of Human Genes and Genetic Disorders. We identified 95 human disorders that have documented aggressive symptoms in at least one individual with a well‐defined genetic variant. Altogether, we retrieved 86 causal genes. Although most of these genes had not been implicated in human aggression by previous studies, the most significantly enriched canonical pathways had been previously implicated in aggression (e.g., serotonin and dopamine signaling). Our findings provide strong evidence to support the causal role of these pathways in the pathogenesis of aggression. In addition, the novel genes and pathways we identified suggest additional mechanisms underlying the origins of human aggression. Genome‐wide association studies with very large samples will be needed to determine if common variants in these genes are risk factors for aggression. © 2015 Wiley Periodicals, Inc.

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Section: Figmentioning

confidence: 99%

Genetic architecture for human aggression: A study of gene–phenotype relationship in OMIM

Zhang-James

Faraone

2015

American J of Med Genetics Pt B

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“…In a study of 35 prepubertal ASD boys (3-10 years old), the testosterone level was determined by drawing venous blood. The results revealed that there was a positive correlation between testosterone level and hyperactivity [8].…”

Section: Testosteronementioning

confidence: 87%

“…Testosterone, cortisol, and oxytocin are the most common. Other hormones such as growth hormones, vasopressin (antidiuretic hormone), melatonin, thyroid hormone, and estrogen have some role in ASD risk [8].…”

Section: Neuroendocrine Dysfunctionmentioning

confidence: 99%

Neuropathology and Neuroendocrine Dysfunction in Autism Spectrum Disorder

Lee¹

2019

Recent Advances in Biology and Medicine

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Autism spectrum disorder (ASD) is a single spectrum disorder. It is characterized by marked social deficit, stereotype behavior, flexibility, sensory sensitivity, and language impairment. However, ASD can also be accompanied by neuropathology and neuroendocrine dysfunction. Higher testosterone level intrauterine is assumed to increase ASD risk in early childhood. There is limited research about the correlation between ASD and neuroendocrine dysfunction.

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A comparison of age, cognitive, hormonal, symptomatic and mood correlates of Aggression towards Others in boys with ASD

Bitsika

Sharpley

Sweeney

et al. 2017

Research in Developmental Disabilities

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P.7.b.012 Testosterone and explosive aggression in children with autism spectrum disorders

Cited by 7 publications

References 0 publications

Genetic architecture for human aggression: A study of gene–phenotype relationship in OMIM

Genetic architecture for human aggression: A study of gene–phenotype relationship in OMIM

Neuropathology and Neuroendocrine Dysfunction in Autism Spectrum Disorder

A comparison of age, cognitive, hormonal, symptomatic and mood correlates of Aggression towards Others in boys with ASD

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