P.7.c.003 Obesogenic capacity of second-generation antipsychotics in naïve-adolescents and their impact on leptin, adiponectin and ghrelin

Pina‐Camacho, Laura; Tapia-Casellas, Cecilia; Rodríguez-Latorre, Pamela; Merchán-Naranjo, Jessica; García-Amador, M.; Fraguas, David; Moreno, C.; Llorente, C.; Parellada, Mara; Arango, Carlos A.

doi:10.1016/s0924-977x(11)70991-9

Cited by 1 publication

(4 citation statements)

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“…Moreover, leptin and adiponectin may be associated with development of quetiapine-related thyroid and metabolic side effects, especially in pediatric antipsychotic-naïve patients. 37 One explanation could be the potential relationship between thyroid hormones and adipose tissue metabolism, as a study showed positive correlation between TSH and body mass index and leptin but negative correlation between TSH and adiponectin. 48 There are a number of important clinical considerations.…”

Section: Discussionmentioning

confidence: 99%

“…There were twenty observational or experimental studies (Table 2) that included a total of 6880 patients who were treated with quetiapine. 2,4,9,[26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42] The number of participants on quetiapine was not reported in one study. 41 Of these patients, the majority were women in the age group 18 to 65 years of age.…”

Section: Clinical and Sociodemographic Characteristicsmentioning

confidence: 99%

“…Four studies investigated quetiapine in 134 children and adolescents. 31,32,37,39 One study assessed the longterm tolerability, safety, and clinical benefit of quetiapine in 184 elderly patients with psychosis. 30 Quetiapine was used mainly for schizophrenia and BD.…”

Section: Clinical and Sociodemographic Characteristicsmentioning

confidence: 99%

“…25 Thirteen observational or experimental studies showed a decrease in thyroxine levels. 2,4,[27][28][29][30][31][32][33][34][35]37,41,42 Among these, TSH level was increased, compared to baseline, in 6 studies. 4,31,34,35,39,42 Three studies that only measured TSH showed no difference in TSH levels.…”

Section: Clinical and Sociodemographic Characteristicsmentioning

confidence: 99%

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Quetiapine‐Induced Thyroid Dysfunction: A Systematic Review

Khoodoruth

Abdo

Ouanes

2021

The Journal of Clinical Pharma

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Thyroid abnormalities are documented consequences of quetiapine treatment. This may have clinical implications as changes in thyroid hormones may deteriorate a person's affective state. Yet less is known about the clinical factors and underlying mechanisms associated with thyroid hormones on quetiapine therapy. We therefore systematically reviewed the published literature of evidence of quetiapine-induced thyroid abnormalities. We searched MEDLINE, PsycINFO, Google Scholar, and EMBASE for articles in which individuals developed biochemically confirmed thyroid abnormalities (with or without clinical symptoms) while on quetiapine treatment. We included case reports, case series, observational, and experimental studies. We included 32 studies, 20 of which were observational and experimental studies. There were 10 case reports and 1 case series. All the research designs suggested an association between quetiapine and hypothyroidism. However, these findings were limited by the quality of the included studies and the general lack of either a clear temporal relationship or dose response. Quetiapine has been associated with thyroid abnormalities, mainly with hypothyroidism. Drug imputability in these abnormalities is not always clear, and the underlying pathophysiology may include immunological and nonimmunological mechanisms. Large prospective studies are required to clarify this association and to further inform the management of patients treated with quetiapine where hypothyroidism occurs.

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Section: Discussionmentioning

confidence: 99%