P.710 Effect of noni juice on learning and memory processes in rats with diazepam-induced amnesia

Georgieva-Kotetarova, M.; Kostadinova, I.; Kostadinov, I.; Delev, Delian; Zlatanova, H.; Kandilarov, I.

doi:10.1016/j.euroneuro.2019.09.751

Cited by 2 publications

(2 citation statements)

References 4 publications

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“…Recent studies suggest that noni has beneficial effects in improving memory functions in mice by reducing oxidative stress and increasing brain levels of brain-derived neurotrophic factor, acetylcholine, and ATP [ 5 , 6 ]. Noni extract inhibited activity against acetylcholine esterase and monoamine oxidase, and the consequent increase in dopamine and serotonin levels in mice [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Noni on Memory Impairment Induced by Hydrocortisone in Mice

Zhang

Liu

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. Oxidative stress and memory impairment have been implicated as common functional brain diseases. Nuclear factor E2-related factor 2 (Nrf2) is highly induced in oxidative stress, indicating that Nrf2 is an emerging target of memory therapy. This study aimed to investigate the effect of noni on brain memory impairment induced by hydrocortisone and its protective mechanism in mice. Methods. Male Kunming mice (n = 8/group) were given hydrocortisone by gastric gavage for 14 consecutive days to establish the memory impairment model, except for those in the control group. On the same day, the corresponding drugs were given by gastric gavage. The changes in ethology were examined. The brains were extracted and subjected to western blot analysis and biochemical analyses to assess the activities of antioxidative stress. Results. The middle- and high-dose noni groups exhibited ameliorated ethology, and the high-dose noni group exhibited increased cerebral protein expression of Nrf2, Kelch-like ECH-associated protein 1 (KEAP1), and haem oxygenase-1 (HO-1) compared to the model group. The arrangement of CA3 vertebral cells in the hippocampus of mice was slightly compact, and hyperchromasia and pyknosis were alleviated. Furthermore, biochemical analyses showed that the activities of enzymes related to oxidative stress in the high-dose noni group were increased. Conclusions. Noni might be a powerful antioxidant that can protect nerve cells and may possess potential benefits for the treatment of memory impairment.

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Section: Introductionmentioning

confidence: 99%

Effect of Noni on Memory Impairment Induced by Hydrocortisone in Mice

Zhang

Liu

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…What's more, some related beverages such as Xisha Noni®, Mornida® have been widely used and also have several dietary supplements which contain Chinese traditional functional food like Ginseng or Cornus o cinalis. Researches show Noni can improve memory [4,5]. Noni has been reported to prevent amyloid beta induced memory impairment in mice [6] and scopolamine induced memory impairment in mice [7].…”

Section: Introductionmentioning

confidence: 99%

Effect of Noni on memory impairment induced by hydrocortisone in mice

Zhang¹,

Liu²,

Hou³

et al. 2021

Preprint

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Background Oxidative stress and memory impairment have been implicated, a common functional brain disease. Nuclear factor E2-related factor 2 (Nrf2) is highly induced in oxidative stress, indicating that Nrf2 is an emerging target of memory therapy. This study aimed to investigate the effect of Noni on brain memory impairment induced by hydrocortisone and its protection mechanism in mice. Methods Male Kuming mice were (n = 8/group) given hydrocortisone by gastric gavage for 14 consecutive days to establish the memory impairment model except for those in the control group. At the same day, the corresponding drugs were given by gastric gavage. The changes in ethology were examined. Brains were extracted and subjected to western blot analysis and biochemical analyses to assess the activities of oxidative stress. Results The middle and high-dose Noni groups ameliorated the ethology and the high-dose Noni group increased cerebral protein expressions of Nrf2, kelch-like ECH-associated protein 1 (KEAP1) and heme oxygenase-1 (HO-1), as compared to the model group. The arrangement of CA3 vertebral cells in hippocampus of mice was slightly compact and hyperchromatic and pyknosis were alleviated. Furthermore, the biochemical analyses showed the activities of related enzymes of oxidative stress in high-dose Noni group were increased. Conclusions Noni might be a powerful antioxidant that can protect nerve cell and may possess as a potential benefit for the treatment of memory impairment.

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P.710 Effect of noni juice on learning and memory processes in rats with diazepam-induced amnesia

Cited by 2 publications

References 4 publications

Effect of Noni on Memory Impairment Induced by Hydrocortisone in Mice

Effect of Noni on Memory Impairment Induced by Hydrocortisone in Mice

Effect of Noni on memory impairment induced by hydrocortisone in mice

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